8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

Product Name: 8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE
CAS No.: 68774-78-7
Chemical Name: 8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE
Synonyms: 8-chloro-3-Methyl-[1;8-Chloro-3-methyltriazolo[4,3-a]pyrazine;8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE;1,2,4-Triazolo[4,3-a]pyrazine, 8-chloro-3-methyl-
CBNumber: CB6354941
Molecular Formula: C6H5ClN4
Formula Weight: 168.58
MOL File: 68774-78-7.mol

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8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE Property

Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
pka: -0.33±0.30(Predicted)
Appearance: Light brown to brown Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C369890
Product name: 8-Chloro-3-methyl-1,2,4-triazolo[4,3-a]pyrazine
Packaging: 500mg
Price: $160
Updated: 2021/12/16

Matrix Scientific

Product number: 120509
Product name: 8-Chloro-3-methyl[1,2,4]triazolo[4,3-a]pyrazine
Purity: >90%
Packaging: 500mg
Price: $241
Updated: 2021/12/16

AK Scientific

Product number: HTS008978
Product name: 8-chloro-3-methyl[1,2,4]triazolo[4,3-a]pyrazine
Packaging: 10mg
Price: $69
Updated: 2021/12/16

AK Scientific

Product number: HTS008978
Product name: 8-chloro-3-methyl[1,2,4]triazolo[4,3-a]pyrazine
Packaging: 50mg
Price: $129
Updated: 2021/12/16

AK Scientific

Product number: 9939CB
Product name: 8-Chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine
Packaging: 1g
Price: $353
Updated: 2021/12/16

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8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE Chemical Properties,Usage,Production

Uses

8-Chloro-3-methyl-1,2,4-triazolo[4,3-a]pyrazine is used as a reagent to synthesize derivatives of Formycin, a C-nucleoside antibiotic that inhibits the influenza A virus and is also known to replace adenosine during transcription.

Synthesis

78-39-7

63286-28-2

68774-78-7

Step 2: Synthesis of 8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine [0197] To a stirred solution of 2-chloro-3-hydrazinopyrazine (2.0 g, 14 mmol) in xylene (20 mL) was slowly added triethyl orthoacetate (5.8 mL, 32 mmol). The reaction mixture was heated under reflux conditions overnight and subsequently cooled to room temperature. The precipitate precipitated was collected by filtration to afford the target compound 8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine as a brown powder (2.0 g, 87% yield). Mass Spectrometry (ESI): Calculated value C6H5ClN4 [M+H]+: 168.0; Measured value: 169.2. 1H NMR (400MHz, CDCl3) δ: 7.80 (d, J=4.8Hz, 1H), 7.71 (d, J=4.8Hz, 1H), 2.83 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 20, p. 4606 - 4613
[2] Patent: WO2016/100349, 2016, A2. Location in patent: Paragraph 0197

8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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68774-78-7, 8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINERelated Search:

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8-chloro-3-Methyl-[1

8-Chloro-3-methyltriazolo[4,3-a]pyrazine

8-CHLORO-3-METHYL-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

1,2,4-Triazolo[4,3-a]pyrazine, 8-chloro-3-methyl-

68774-78-7