1-Hydroxyethylethoxypiperazine

Product Name: 1-Hydroxyethylethoxypiperazine
CAS No.: 13349-82-1
Chemical Name: 1-Hydroxyethylethoxypiperazine
Synonyms: HEP;HEEP;2-(2-PIPERAZIN-1-YL-ETHOXY)-ETHANOL;Quetiapine intermediate;1-[2-(2-HYDROXYETHOXY)ETHYL]PIPERAZINE;EPB6;HEP crystal;1-piperazidine;Hydroxyzine Impurity 1;Quetiapine Impurity 44
CBNumber: CB6358565
Molecular Formula: C8H18N2O2
Formula Weight: 174.24
MOL File: 13349-82-1.mol

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1-Hydroxyethylethoxypiperazine Property

Boiling point:: 112-114 °C0.25 mm Hg(lit.)
Density: 1.061 g/mL at 25 °C(lit.)
refractive index: n20/D 1.497(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form: Liquid
pka: 14.41±0.10(Predicted)
Specific Gravity: 1.061
color: Clear colorless to yellow-brownish
InChI: InChI=1S/C8H18N2O2/c11-6-8-12-7-5-10-3-1-9-2-4-10/h9,11H,1-8H2
InChIKey: FLNQAPQQAZVRDA-UHFFFAOYSA-N
SMILES: C(O)COCCN1CCNCC1
CAS DataBase Reference: 13349-82-1(CAS DataBase Reference)
NIST Chemistry Reference: 1-(2-(2-Hydroxyethoxy)ethyl)piperazine(13349-82-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 331260
Product name: 1-[2-(2-Hydroxyethoxy)ethyl]piperazine
Purity: 95%
Packaging: 5g
Price: $57.6
Updated: 2025/07/31

TCI Chemical

Product number: H1192
Product name: 1-[2-(2-Hydroxyethoxy)ethyl]piperazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: H1192
Product name: 1-[2-(2-Hydroxyethoxy)ethyl]piperazine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $105
Updated: 2025/07/31

TRC

Product number: H941910
Product name: 1-[2-(2-Hydroxyethoxy)ethyl]piperazine
Packaging: 50g
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: A220
Product name: 1-[2-(2-Hydroxyethoxyl)-ethyl]piperazine
Packaging: 5g
Price: $14
Updated: 2021/12/16

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1-Hydroxyethylethoxypiperazine Chemical Properties,Usage,Production

Chemical Properties

Yellow-Brown Oil

Uses

1-[2-(2-Hydroxyethoxy)ethyl]piperazine may be used in chemical synthesis.

Uses

Quetiapine intermediate

Definition

ChEBI: 1-(2-(2-Hydroxyethoxy)ethyl)piperazine is a N-alkylpiperazine.

Synthesis

166388-52-9

13349-82-1

The general procedure for the synthesis of 1-[2-(2-hydroxyethoxy)ethyl]piperazine from the compound (CAS:166388-52-9) was as follows: 54.2 g of compound 3 was dissolved in 300 mL of dichloromethane, followed by the addition of 26 g of trifluoroacetic acid. The reaction mixture was stirred at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was complete. After completion of the reaction, 1 N NaOH aqueous solution was added and stirring was continued for 30 minutes. The reaction mixture was left to partition and the organic phase was separated. The organic phase was dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 32.6 g of a colorless liquid product, i.e., 1-[2-(2-hydroxyethoxy)ethyl]piperazine. The yield was 95%.

References

[1] Patent: CN107663183, 2018, A. Location in patent: Paragraph 0022; 0023; 0024

1-Hydroxyethylethoxypiperazine Preparation Products And Raw materials

Raw materials

PIPERAZINE DIHYDROCHLORIDE PIPERAZINE HEXAHYDRATE Chloroethoxyethanol

Preparation Products

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1-Hydroxyethylethoxypiperazine Suppliers

Americas 1 Belgium 2 Canada 1 China 318 Europe 4 France 3 Germany 6 India 77 Ireland 1 Japan 6 Slovakia 3 South Korea 1 Spain 1 Switzerland 3 Ukraine 1 United Kingdom 14 United States 50 Global 492

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View Lastest Price from 1-Hydroxyethylethoxypiperazine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-Hydroxyethylethoxypiperazine 13349-82-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-07-05

Hebei Yanxi Chemical Co., Ltd.

Product: 1-Hydroxyethylethoxypiperazine 13349-82-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-13

Wuhan Boyuan Import & Export Co., LTD

Product: 1-[2-(2-Hydroxyethoxy)ethyl]piperazine 13349-82-1
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000/tons
Release date: 2024-03-25

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1-Hydroxyethylethoxypiperazine ISO 9001：2015 REACH

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