Cetirizine
- Product Name
- Cetirizine
- CAS No.
- 83881-51-0
- Chemical Name
- Cetirizine
- Synonyms
- CETIRIZINE LACTOSE ESTER;vidix;P-071;Zyrlex;Zirtek;Reactine;Formistin;Ceterizine;CETIRIZINE;CETIRIZINE BASE
- CBNumber
- CB3440625
- Molecular Formula
- C21H25ClN2O3
- Formula Weight
- 388.89
- MOL File
- 83881-51-0.mol
Cetirizine Property
- Melting point:
- 110-115°C
- Boiling point:
- 542.1±45.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- insoluble in EtOH; ≥122 mg/mL in H2O; ≥19.44 mg/mL in DMSO
- form
- solid
- pka
- 3.46±0.10(Predicted)
- color
- Off-white to light yellow
- Water Solubility
- 101 mg/L
- CAS DataBase Reference
- 83881-51-0(CAS DataBase Reference)
- EPA Substance Registry System
- Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- (83881-51-0)
Safety
- WGK Germany
- 3
- RTECS
- AG0977500
- Hazardous Substances Data
- 83881-51-0(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3298
- Product name
- Cetirizine
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- API0007068
- Product name
- CETIRIZINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $253.05
- Updated
- 2021/12/16
- Product number
- orb611889
- Product name
- Cetirizine
- Purity
- >98%
- Packaging
- 200mg
- Price
- $277.1
- Updated
- 2021/12/16
- Product number
- orb611889
- Product name
- Cetirizine
- Purity
- >98%
- Packaging
- 500mg
- Price
- $414.8
- Updated
- 2021/12/16
- Product number
- orb611889
- Product name
- Cetirizine
- Purity
- >98%
- Packaging
- 1g
- Price
- $615.4
- Updated
- 2021/12/16
Cetirizine Chemical Properties,Usage,Production
Chemical Properties
white, crystalline powder
Uses
Cetirizine is a metabolite of the first-generation H1 antihistamine hydroxyzine. A reduced dosage (5 mg daily) is recommended in patients with chronic renal or hepatic impairment. Sedative side effects increase with dosages of cetirizine >10 mg per day.
Definition
ChEBI: A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
brand name
Zyrtec (Pfizer).
General Description
Cetirizine, (±)-[2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetic acid (Zyrtec), is a racemic compound available as a white crystalline powder that is water soluble. Cetirizine is the primary acid metabolite of hydroxyzine, resulting from complete oxidation of the primary alcohol moiety. This compound is zwitterionic and relatively polar and thus does not penetrate or accumulate in the CNS. Before its introduction in the United States, cetirizine was one of the most widely prescribed H1-antihistamines in Europe.
Cetirizine is indicated for the temporary relief of runny nose, sneezing, itching of the nose or throat, and/or itchy, watery eyes caused by hay fever or other upper respiratory allergies. It also relieves itching caused by hives (urticaria), but it will not prevent hives or an allergic skin reaction from occurring.
Biological Activity
cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective h1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. it has also been shown to inhibit eosinophil chemotaxis and ltb4 release. at a dosage of 20 mg, boone et al. found that it inhibited the expression of vcam-1 in patients with atopic dermatitis. the levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. from wikipedia.
Clinical Use
Cetirizine, the acid metabolite from oxidation of the primary alcohol of the antihistamine hydroxyzine, is a widely used antihistamine. It has a long duration of action and is highly selective for H1 receptors. No cardiotoxicity has been reported, but some drowsiness occurs.
Cetirizine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cetirizine manufacturers
- Product
- Cetirizine 83881-51-0
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-28
- Product
- Cetirizine 83881-51-0
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Cetirizine 83881-51-0
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-25