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Levocetirizine

Product Name
Levocetirizine
CAS No.
130018-77-8
Chemical Name
Levocetirizine
Synonyms
alerlisin;Cetirizine-d4;LEVOCETRIZINE;LEVOCETIRIZINE;(R)-Cetirizine;Levocetirizine-d4;(R)-Cetirizine-d4;Cetirizine R-Isomer;Cetirizine Impurity 20;-2-(2-(4-((4-Chlorophenyl)
CBNumber
CB5712207
Molecular Formula
C21H25ClN2O3
Formula Weight
388.89
MOL File
130018-77-8.mol
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Levocetirizine Property

Melting point:
205-208°C (dec.)
Boiling point:
542.1±45.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
pka
3.46±0.10(Predicted)
CAS DataBase Reference
130018-77-8(CAS DataBase Reference)
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Safety

HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

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Levocetirizine Chemical Properties,Usage,Production

Description

The (R)-enantiomer of the second-generation antihistamine cetirizine, levocetirizine, was first introduced in Germany for seasonal allergic rhinitis (including ocular symptoms), perennial allergic rhinitis and chronic idiopathic urticaria. The dihydrochloride salt can be prepared in four steps from optically active 4-chlorobenzhydrylamine obtained by resolution of its racemate with (+)-tartaric acid. Levocetirizine (eutomer) is a 2-fold more potent H1 antagonist than cetirizine whereas the other enantiomer (distomer) is 10-fold less potent compared to levocetirizine. Pharmacodynamic studies on healthy volunteers showed that compared to cetirizine, half the dose of levocetirizine (5 mg) was necessary to obtain similar inhibitory effects in the skin test of histamine-induced wheal and flare as well as on histamine-induced nasal congestion and nasal resistance. There was no evidence of chiral inversion of levocetirizine in vivo in several species including human. The daily dose of drug is rapidly and extensively absorbed in human. Interestingly, its volume of distribution (0.41 kg/L) is smaller than that of the distomer (0.60 kg/L). The low volume of distribution is considered as favorable for an antihistamine both in terms of efficacy and safety. Due to its high metabolic stability and lack of effect on the activities of the major CYP isoenzymes, levocetirizine is unlikely to cause interactions with other administered drugs. No clinically relevant effect on electrocardiograms of healthy volunteers was detected.

Chemical Properties

Off-White Solid

Originator

Sepracor (US)

Uses

A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.

Uses

H1 antihistamine, antiallergic

Uses

Labeled cetirizine, intended for use as an internal standard for the quantification of cetirizine by GC- or LC-mass spectrometry.

brand name

Xusal

Levocetirizine Preparation Products And Raw materials

Raw materials

Preparation Products

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Levocetirizine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8945
Advantage
52
Shanghai Fuhe Chemistry Technology Co., Ltd.
Tel
0086-21-67651709
Fax
0086-21-67651705
Email
cfx759@hotmail.com
Country
China
ProdList
410
Advantage
57
BOC Sciences
Tel
Email
info@bocsci.com
Country
United States
ProdList
9984
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810- ;025-57798810-
Fax
025-57019371
Email
sales@sunlidabio.com;sales@sunlidabio.com
Country
China
ProdList
3814
Advantage
55
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4938
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
19212
Advantage
56
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View Lastest Price from Levocetirizine manufacturers

Career Henan Chemical Co
Product
Levocetirizine 130018-77-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-12-18

130018-77-8, LevocetirizineRelated Search:


  • LEVOCETIRIZINE
  • alerlisin
  • 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
  • Cetirizine Impurity 20
  • (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
  • LEVOCETRIZINE
  • (R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride
  • LevocetirizineHydrochloride
  • 2-[2-[4-[(4-Chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid
  • Cetirizine-d4
  • Levocetirizine-d4
  • (R)-Cetirizine
  • (R)-Cetirizine Dihydrochloride
  • 2-[2-[4-[(R)-(4-Chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride
  • (R)-Cetirizine-d4
  • -2-(2-(4-((4-Chlorophenyl)
  • Cetirizine R-Isomer
  • Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
  • Levoce/0/2/7/5/9/8/4/7/2/5/5/-tirizine
  • 130018-77-8
  • C21H21ClN2O3D4
  • C21H25ClN2O3
  • XYZAL
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals