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Levocetirizine

Product Name
Levocetirizine
CAS No.
130018-77-8
Chemical Name
Levocetirizine
Synonyms
LEVOCETRIZINE;(R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride;alerlisin;Cetirizine-d4;LEVOCETIRIZINE;(R)-Cetirizine;Levocetirizine-d4;(R)-Cetirizine-d4;Cetirizine R-Isomer;Levocetirizine-IP/IHS
CBNumber
CB5712207
Molecular Formula
C21H25ClN2O3
Formula Weight
388.89
MOL File
130018-77-8.mol
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Levocetirizine Property

Melting point:
205-208°C (dec.)
Boiling point:
542.1±45.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: 78 mg/mL (200.57 mM);Ethanol: 78 mg/mL (200.57 mM)
pka
3.46±0.10(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
Water: 78 mg/mL (200.57 mM)
BCS Class
3
CAS DataBase Reference
130018-77-8(CAS DataBase Reference)
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Safety

HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
L379253
Product name
Levocetirizine
Packaging
50mg
Price
$125
Updated
2021/12/16
TRC
Product number
L379253
Product name
Levocetirizine
Packaging
500mg
Price
$795
Updated
2021/12/16
TRC
Product number
L379253
Product name
Levocetirizine
Packaging
1g
Price
$1400
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003160
Product name
LEVOCETIRIZINE HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$644.46
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003160
Product name
LEVOCETIRIZINE HYDROCHLORIDE
Purity
95.00%
Packaging
5G
Price
$867.48
Updated
2021/12/16
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Levocetirizine Chemical Properties,Usage,Production

Description

The (R)-enantiomer of the second-generation antihistamine cetirizine, levocetirizine, was first introduced in Germany for seasonal allergic rhinitis (including ocular symptoms), perennial allergic rhinitis and chronic idiopathic urticaria. The dihydrochloride salt can be prepared in four steps from optically active 4-chlorobenzhydrylamine obtained by resolution of its racemate with (+)-tartaric acid. Levocetirizine (eutomer) is a 2-fold more potent H1 antagonist than cetirizine whereas the other enantiomer (distomer) is 10-fold less potent compared to levocetirizine. Pharmacodynamic studies on healthy volunteers showed that compared to cetirizine, half the dose of levocetirizine (5 mg) was necessary to obtain similar inhibitory effects in the skin test of histamine-induced wheal and flare as well as on histamine-induced nasal congestion and nasal resistance. There was no evidence of chiral inversion of levocetirizine in vivo in several species including human. The daily dose of drug is rapidly and extensively absorbed in human. Interestingly, its volume of distribution (0.41 kg/L) is smaller than that of the distomer (0.60 kg/L). The low volume of distribution is considered as favorable for an antihistamine both in terms of efficacy and safety. Due to its high metabolic stability and lack of effect on the activities of the major CYP isoenzymes, levocetirizine is unlikely to cause interactions with other administered drugs. No clinically relevant effect on electrocardiograms of healthy volunteers was detected.

Chemical Properties

Off-White Solid

Originator

Sepracor (US)

Uses

A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.

Uses

H1 antihistamine, antiallergic

Uses

Labeled cetirizine, intended for use as an internal standard for the quantification of cetirizine by GC- or LC-mass spectrometry.

Definition

ChEBI: 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid is a diarylmethane.

brand name

Xusal

Clinical Use

Antihistamine:
Symptomatic relief of allergy such as hay fever, urticaria

Levocetirizine Preparation Products And Raw materials

Raw materials

Preparation Products

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Levocetirizine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Shanghai Fuhe Chemistry Technology Co., Ltd.
Tel
0086-21-67651709
Fax
0086-21-67651705
Email
cfx759@hotmail.com
Country
China
ProdList
410
Advantage
57
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
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View Lastest Price from Levocetirizine manufacturers

Hebei Mingeng Biotechnology Co., Ltd
Product
Levocetirizine 130018-77-8
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-27
Shijiazhuang Gantuo Biotechnology Co., Ltd
Product
Levocetirizine 130018-77-8
Price
US $100.00/mg
Min. Order
10mg
Purity
99%
Supply Ability
10000g
Release date
2023-03-10
Career Henan Chemical Co
Product
Levocetirizine 130018-77-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-12-18

130018-77-8, LevocetirizineRelated Search:


  • LEVOCETIRIZINE
  • alerlisin
  • 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
  • Cetirizine Impurity 20
  • (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
  • LEVOCETRIZINE
  • (R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride
  • LevocetirizineHydrochloride
  • 2-[2-[4-[(4-Chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid
  • Cetirizine-d4
  • Levocetirizine-d4
  • (R)-Cetirizine
  • (R)-Cetirizine Dihydrochloride
  • 2-[2-[4-[(R)-(4-Chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride
  • (R)-Cetirizine-d4
  • -2-(2-(4-((4-Chlorophenyl)
  • Cetirizine R-Isomer
  • Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
  • Levoce/0/2/7/5/9/8/4/7/2/5/5/-tirizine
  • Levocetirizine-IP/IHS
  • LevocetirizineQ: What is Levocetirizine Q: What is the CAS Number of Levocetirizine Q: What is the storage condition of Levocetirizine
  • Benodanil Impurity 17 (Pyracarbolid)
  • Levocetirizine Hydrochloride IP / USP
  • Levocetirizine (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1- yl)ethoxy)acetic acid
  • LevocetirizineDihydrochloride(USP)
  • 130018-77-8
  • C21H21ClN2O3D4
  • C21H25ClN2O3
  • XYZAL
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals