Levocetirizine
- Product Name
- Levocetirizine
- CAS No.
- 130018-77-8
- Chemical Name
- Levocetirizine
- Synonyms
- LEVOCETRIZINE;(R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride;alerlisin;Cetirizine-d4;LEVOCETIRIZINE;(R)-Cetirizine;Levocetirizine-d4;(R)-Cetirizine-d4;Cetirizine R-Isomer;Levocetirizine-IP/IHS
- CBNumber
- CB5712207
- Molecular Formula
- C21H25ClN2O3
- Formula Weight
- 388.89
- MOL File
- 130018-77-8.mol
Levocetirizine Property
- Melting point:
- 205-208°C (dec.)
- Boiling point:
- 542.1±45.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: 78 mg/mL (200.57 mM);Ethanol: 78 mg/mL (200.57 mM)
- pka
- 3.46±0.10(Predicted)
- Water Solubility
- Water: 78 mg/mL (200.57 mM)
- BCS Class
- 3
- CAS DataBase Reference
- 130018-77-8(CAS DataBase Reference)
Safety
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L379253
- Product name
- Levocetirizine
- Packaging
- 50mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- L379253
- Product name
- Levocetirizine
- Packaging
- 500mg
- Price
- $795
- Updated
- 2021/12/16
- Product number
- L379253
- Product name
- Levocetirizine
- Packaging
- 1g
- Price
- $1400
- Updated
- 2021/12/16
- Product number
- API0003160
- Product name
- LEVOCETIRIZINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $644.46
- Updated
- 2021/12/16
- Product number
- API0003160
- Product name
- LEVOCETIRIZINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $867.48
- Updated
- 2021/12/16
Levocetirizine Chemical Properties,Usage,Production
Description
The (R)-enantiomer of the second-generation antihistamine cetirizine, levocetirizine, was first introduced in Germany for seasonal allergic rhinitis (including ocular symptoms), perennial allergic rhinitis and chronic idiopathic urticaria. The dihydrochloride salt can be prepared in four steps from optically active 4-chlorobenzhydrylamine obtained by resolution of its racemate with (+)-tartaric acid. Levocetirizine (eutomer) is a 2-fold more potent H1 antagonist than cetirizine whereas the other enantiomer (distomer) is 10-fold less potent compared to levocetirizine. Pharmacodynamic studies on healthy volunteers showed that compared to cetirizine, half the dose of levocetirizine (5 mg) was necessary to obtain similar inhibitory effects in the skin test of histamine-induced wheal and flare as well as on histamine-induced nasal congestion and nasal resistance. There was no evidence of chiral inversion of levocetirizine in vivo in several species including human. The daily dose of drug is rapidly and extensively absorbed in human. Interestingly, its volume of distribution (0.41 kg/L) is smaller than that of the distomer (0.60 kg/L). The low volume of distribution is considered as favorable for an antihistamine both in terms of efficacy and safety. Due to its high metabolic stability and lack of effect on the activities of the major CYP isoenzymes, levocetirizine is unlikely to cause interactions with other administered drugs. No clinically relevant effect on electrocardiograms of healthy volunteers was detected.
Chemical Properties
Off-White Solid
Originator
Sepracor (US)
Uses
A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
Uses
H1 antihistamine, antiallergic
Uses
Labeled cetirizine, intended for use as an internal standard for the quantification of cetirizine by GC- or LC-mass spectrometry.
Definition
ChEBI: 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid is a diarylmethane.
brand name
Xusal
Clinical Use
Antihistamine:
Symptomatic relief of allergy such as hay fever,
urticaria
Levocetirizine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Levocetirizine manufacturers
- Product
- Levocetirizine 130018-77-8
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2022-10-17
- Product
- Levocetirizine 130018-77-8
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-27
- Product
- Levocetirizine 130018-77-8
- Price
- US $100.00/mg
- Min. Order
- 10mg
- Purity
- 99%
- Supply Ability
- 10000g
- Release date
- 2023-03-10