ChemicalBook > CAS DataBase List > Cetirizine

Cetirizine

Product Name: Cetirizine
CAS No.: 83881-51-0
Chemical Name: Cetirizine
Synonyms: CETIRIZINE LACTOSE ESTER;vidix;P-071;Zyrlex;Zirtek;Reactine;Formistin;Ceterizine;CETIRIZINE;CETIRIZINE BASE
CBNumber: CB3440625
Molecular Formula: C21H25ClN2O3
Formula Weight: 388.89
MOL File: 83881-51-0.mol

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Cetirizine Property

Melting point:: 110-115°C
Boiling point:: 542.1±45.0 °C(Predicted)
Density: 1.237±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: insoluble in EtOH; ≥122 mg/mL in H2O; ≥19.44 mg/mL in DMSO
form: solid
pka: 3.46±0.10(Predicted)
color: Off-white to light yellow
Water Solubility: 101 mg/L
InChI: InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)
InChIKey: ZKLPARSLTMPFCP-UHFFFAOYSA-N
SMILES: C(O)(=O)COCCN1CCN(C(C2=CC=C(Cl)C=C2)C2=CC=CC=C2)CC1
CAS DataBase Reference: 83881-51-0(CAS DataBase Reference)
EPA Substance Registry System: Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- (83881-51-0)

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Safety

WGK Germany: 3
RTECS: AG0977500
Hazardous Substances Data: 83881-51-0(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3298
Product name: Cetirizine
Packaging: 100mg
Price: $50
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007068
Product name: CETIRIZINE
Purity: 95.00%
Packaging: 1G
Price: $253.05
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611889
Product name: Cetirizine
Purity: >98%
Packaging: 200mg
Price: $277.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611889
Product name: Cetirizine
Purity: >98%
Packaging: 500mg
Price: $414.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611889
Product name: Cetirizine
Purity: >98%
Packaging: 1g
Price: $615.4
Updated: 2021/12/16

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Cetirizine Chemical Properties,Usage,Production

Chemical Properties

white, crystalline powder

Uses

Cetirizine is a metabolite of the first-generation H1 antihistamine hydroxyzine. A reduced dosage (5 mg daily) is recommended in patients with chronic renal or hepatic impairment. Sedative side effects increase with dosages of cetirizine >10 mg per day.

Definition

ChEBI: A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.

brand name

Zyrtec (Pfizer).

General Description

Cetirizine, (±)-[2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetic acid (Zyrtec), is a racemic compound available as a white crystalline powder that is water soluble. Cetirizine is the primary acid metabolite of hydroxyzine, resulting from complete oxidation of the primary alcohol moiety. This compound is zwitterionic and relatively polar and thus does not penetrate or accumulate in the CNS. Before its introduction in the United States, cetirizine was one of the most widely prescribed H1-antihistamines in Europe.
Cetirizine is indicated for the temporary relief of runny nose, sneezing, itching of the nose or throat, and/or itchy, watery eyes caused by hay fever or other upper respiratory allergies. It also relieves itching caused by hives (urticaria), but it will not prevent hives or an allergic skin reaction from occurring.

Biological Activity

cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective h1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. it has also been shown to inhibit eosinophil chemotaxis and ltb4 release. at a dosage of 20 mg, boone et al. found that it inhibited the expression of vcam-1 in patients with atopic dermatitis. the levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. from wikipedia.

Clinical Use

Cetirizine, the acid metabolite from oxidation of the primary alcohol of the antihistamine hydroxyzine, is a widely used antihistamine. It has a long duration of action and is highly selective for H1 receptors. No cardiotoxicity has been reported, but some drowsiness occurs.

Cetirizine Preparation Products And Raw materials

Raw materials

Ethoxyacetic acid

Preparation Products

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View Lastest Price from Cetirizine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Cetirizine 83881-51-0
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-28

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Cetirizine 83881-51-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-04-19

Hebei Yanxi Chemical Co., Ltd.

Product: Cetirizine 83881-51-0
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-25

83881-51-0, CetirizineRelated Search:

acetic acid, triethoxy-, ethyl ester 1-Methylpiperazine Triphenyltin acetate Methyl 2,2-dimethylphenylacetate Dimethylbenzylcarbinyl acetate Chlorodimethylphenylsilane Silicone oil (high temperature) Methylparaben Pivalic acid Loratadine Ebastine Cetirizine dihydrochloride Levoceitrizine Hcl Cetirizine-d4 CETIRIZINE DIHYDROCHLORIDE MM(CRM STANDARD),CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD) Levocetirizine dihydrochloride CETIRIZINE N-OXIDE CETIRIZINE-D8

2-[2-[4-(4-Chlorobenzhydryl)-1-piperazinyl]ethoxy]acetic acid

2-[4-(4-Chlorobenzhydryl)-1-piperazinyl]ethoxyacetic acid

5-[4-[(4-Chlorophenyl)phenylmethyl]piperazino]-3-oxapentanoic acid

Ceterizine

Cetirizine DISCONTINUED (Replaced with C1876)

2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)Methyl]piperazin-1-yl}ethoxy)acetic acid

CETIRIZINE LACTOSE ESTER

vidix

Zirtek

Zyrlex

Cetirizine(EP/BP)

(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-aceticaci

(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticacid

CETIRIZINE

(2-(4-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZIN-1-YL)-ETHOXY)-ACETIC ACID

Cetirizine Hydrochloride BP

Cetirizine (Cetrizine) Di HCl

CERTIRIZINE 2HCL

CETIRIZINE IMPURITY A(RS)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE EPC(CRM STANDARD)

Cetrizinehydrochloride

(RS)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride

2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid

Formistin

P-071

Reactine

Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-

Cetirizine USP/EP/BP

CETERIZINE DIHYDROCHLORIDE

Cetirizine DISCONTINUED, offer C281100

Cetirizine Imp(unknown)(pure)

Cetirizine DIHCL- EP/IP/USP/Ph. Eur

2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid[Cetirizine

(2-(4-((4-Chlorophenyl)phenylmethyl)piperazin-1-yl)ethoxy)-aceticaci

Cetirizine Hydrochloride API

CETIRIZINE BASE

83881-51-0

C21H25ClN2O32HCl