ChemicalBook > CAS DataBase List > 1-Hydroxyethylethoxypiperazine

1-Hydroxyethylethoxypiperazine

Product Name
1-Hydroxyethylethoxypiperazine
CAS No.
13349-82-1
Chemical Name
1-Hydroxyethylethoxypiperazine
Synonyms
HEP;HEEP;2-(2-PIPERAZIN-1-YL-ETHOXY)-ETHANOL;Quetiapine intermediate;1-[2-(2-HYDROXYETHOXY)ETHYL]PIPERAZINE;EPB6;HEP crystal;1-piperazidine;Hydroxyzine Impurity 1;Quetiapine Impurity 44
CBNumber
CB6358565
Molecular Formula
C8H18N2O2
Formula Weight
174.24
MOL File
13349-82-1.mol
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1-Hydroxyethylethoxypiperazine Property

Boiling point:
112-114 °C0.25 mm Hg(lit.)
Density 
1.061 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.497(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form 
Liquid
pka
14.41±0.10(Predicted)
Specific Gravity
1.061
color 
Clear colorless to yellow-brownish
InChI
InChI=1S/C8H18N2O2/c11-6-8-12-7-5-10-3-1-9-2-4-10/h9,11H,1-8H2
InChIKey
FLNQAPQQAZVRDA-UHFFFAOYSA-N
SMILES
C(O)COCCN1CCNCC1
CAS DataBase Reference
13349-82-1(CAS DataBase Reference)
NIST Chemistry Reference
1-(2-(2-Hydroxyethoxy)ethyl)piperazine(13349-82-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
331260
Product name
1-[2-(2-Hydroxyethoxy)ethyl]piperazine
Purity
95%
Packaging
5g
Price
$57.6
Updated
2025/07/31
TCI Chemical
Product number
H1192
Product name
1-[2-(2-Hydroxyethoxy)ethyl]piperazine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
H1192
Product name
1-[2-(2-Hydroxyethoxy)ethyl]piperazine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$105
Updated
2025/07/31
TRC
Product number
H941910
Product name
1-[2-(2-Hydroxyethoxy)ethyl]piperazine
Packaging
50g
Price
$165
Updated
2021/12/16
AK Scientific
Product number
A220
Product name
1-[2-(2-Hydroxyethoxyl)-ethyl]piperazine
Packaging
5g
Price
$14
Updated
2021/12/16
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1-Hydroxyethylethoxypiperazine Chemical Properties,Usage,Production

Chemical Properties

Yellow-Brown Oil

Uses

1-[2-(2-Hydroxyethoxy)ethyl]piperazine may be used in chemical synthesis.

Uses

Quetiapine intermediate

Definition

ChEBI: 1-(2-(2-Hydroxyethoxy)ethyl)piperazine is a N-alkylpiperazine.

Synthesis

166388-52-9

13349-82-1

The general procedure for the synthesis of 1-[2-(2-hydroxyethoxy)ethyl]piperazine from the compound (CAS:166388-52-9) was as follows: 54.2 g of compound 3 was dissolved in 300 mL of dichloromethane, followed by the addition of 26 g of trifluoroacetic acid. The reaction mixture was stirred at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was complete. After completion of the reaction, 1 N NaOH aqueous solution was added and stirring was continued for 30 minutes. The reaction mixture was left to partition and the organic phase was separated. The organic phase was dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 32.6 g of a colorless liquid product, i.e., 1-[2-(2-hydroxyethoxy)ethyl]piperazine. The yield was 95%.

References

[1] Patent: CN107663183, 2018, A. Location in patent: Paragraph 0022; 0023; 0024

1-Hydroxyethylethoxypiperazine Preparation Products And Raw materials

Raw materials

PIPERAZINE DIHYDROCHLORIDE PIPERAZINE HEXAHYDRATE Chloroethoxyethanol

Preparation Products

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View Lastest Price from 1-Hydroxyethylethoxypiperazine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1-Hydroxyethylethoxypiperazine 13349-82-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-07-05
Hebei Yanxi Chemical Co., Ltd.
Product
1-Hydroxyethylethoxypiperazine 13349-82-1
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-13
Wuhan Boyuan Import & Export Co., LTD
Product
1-[2-(2-Hydroxyethoxy)ethyl]piperazine 13349-82-1
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000/tons
Release date
2024-03-25

13349-82-1, 1-HydroxyethylethoxypiperazineRelated Search:

Ethanol Ethoxyquin Ethyl acetate 4-Ethyl-5-fluoro-6-hydroxypyrimidine 2-Ethoxyethanol DIETHOXYMETHANE 1-Hydroxyethylidene-1,1-diphosphonic acid 4-Ethoxyphenol 1-(2-Hydroxyethyl)piperazine N-Aminoethylpiperazine Cetirizine Hydroxyzine Decloxizine Efletirizine Quetiapine Etodroxizine Hydroxyzine dihydrochloride Ethoxy

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