ChemicalBook > CAS DataBase List > SB 222200

SB 222200

Product Name: SB 222200
CAS No.: 174635-69-9
Chemical Name: SB 222200
Synonyms: CS-1124;SB 222200;SB-222200; SB222200;SB-222200, 10 mM in DMSO;(S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(S)-3-METHYL-2-PHENYL-N-(1-PHENYLPROPYL)-4-QUINOLINECARBOXAMIDE;3-Methyl-2-phenyl-N-((1S)-1-phenylpropyl)quinoline-4-carboxamide;3-METHYL-2-PHENYL-N-[(1S)-1-PHENYLPROPYL]-4-QUINOLINECARBOXAMIDE;4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-;SB222200//3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide
CBNumber: CB6358752
Molecular Formula: C26H24N2O
Formula Weight: 380.48
MOL File: 174635-69-9.mol

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SB 222200 Property

Melting point:: 154℃
Boiling point:: 553.5±50.0 °C(Predicted)
Density: 1.142
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: ~28 mg/mL, soluble
form: solid
pka: 12.88±0.46(Predicted)
color: light yellow

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S5192
Product name: SB 222200
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $189
Updated: 2025/07/31

Sigma-Aldrich

Product number: S5192
Product name: SB 222200
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $869
Updated: 2025/07/31

TCI Chemical

Product number: B6551
Product name: SB 222200
Packaging: 10MG
Price: $192
Updated: 2025/07/31

Cayman Chemical

Product number: 29422
Product name: SB 222200
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 29422
Product name: SB 222200
Packaging: 50mg
Price: $923
Updated: 2024/03/01

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SB 222200 Chemical Properties,Usage,Production

Uses

3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide is a chemical agent used in the preparation of acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor as antipsychotics (1,2).

Definition

ChEBI: 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide is a member of quinolines.

Biological Activity

Potent and selective non-peptide NK 3 receptor antagonist. K i values are 4.4, >100,000 and 250 nM for human NK 3 , NK 1 and NK 2 receptors respectively. Brain penetrant and active in vivo .

in vivo

SB-222200 (5 mg/kg; 30 min pretreatment) produces inhibition of behavioral responses induced by NK-3 receptor-selective agonist senktide (HY-P0187) in mice^[1].
SB-2222006 exhibits moderate oral bioavailability (rat 46%) and C_max (rat 427 ng/mL) following oral administration (rat 10 mg/kg)^[1].
SB-2222006 exhibits terminal elimination half-life (rat 1.9 h) due to high plasma clearance (56 mL/min/kg) following intravenous administration (rat 2.5 mg/kg)^[1].

Animal Model:	Male BALB/c mice (19-21 g)^[1]
Dosage:	5 mg/kg
Administration:	Oral administration
Result:	Produced 57% inhibition of senktide-induced behavioral responses in mice.

Animal Model:	Male Sprague-Dawley rats (300-400 g)^[1]
Dosage:	2.5 mg/kg for i.v.; 10 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration:	Intravenous injection and oral gavage
Result:	Oral bioavailability (46%), T_1/2 (1.9 h), C_max (427 ng/mL).

IC 50

NK3

storage

Store at RT

SB 222200 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 222200 Suppliers

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174635-69-9, SB 222200Related Search:

Acetanilide 4-Aminodiphenylamine 2-methylquinoline-4-carboxamide SB 222200, [3H] SB 222200 3-METHYL-PYRIDINE-4-CARBOXAMIDE N-METHYL-1-QUINOLIN-4-YLMETHANAMINE N-(1-Methylpropyl)-4-pyridinecarboxamide CHEMBRDG-BB 9071023

3-METHYL-2-PHENYL-N-[(1S)-1-PHENYLPROPYL]-4-QUINOLINECARBOXAMIDE

3-Methyl-2-phenyl-N-((1S)-1-phenylpropyl)quinoline-4-carboxamide

SB222200//3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide

(S)-3-METHYL-2-PHENYL-N-(1-PHENYLPROPYL)-4-QUINOLINECARBOXAMIDE

SB 222200

SB-222200; SB222200

CS-1124

4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-

(S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide

SB-222200, 10 mM in DMSO

174635-69-9