Heptaethylene Glycol Monomethyl Ether
- Product Name
- Heptaethylene Glycol Monomethyl Ether
- CAS No.
- 4437-01-8
- Chemical Name
- Heptaethylene Glycol Monomethyl Ether
- Synonyms
- 2,5,8,11,14,17,20-Heptaoxadocosan-22-ol;mPEG7;MPEG7-OH;m-PEG7-alcohol;926630;MEO-PEG(7)-OH;HO-(CH2CH2O)7-Me;Methyl-PEG7-alcohol;MONOMETHOXY-PEG (N=7);METHOXYHEPTAETHYLENE GLYCOL
- CBNumber
- CB6362485
- Molecular Formula
- C15H32O8
- Formula Weight
- 340.41
- MOL File
- 4437-01-8.mol
Heptaethylene Glycol Monomethyl Ether Property
- Boiling point:
- 150 °C(Press: 0.005 Torr)
- Density
- 1.09
- refractive index
- 1.4540-1.4580
- storage temp.
- -20°C
- form
- clear liquid
- pka
- 14.36±0.10(Predicted)
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C15H32O8/c1-17-4-5-19-8-9-21-12-13-23-15-14-22-11-10-20-7-6-18-3-2-16/h16H,2-15H2,1H3
- InChIKey
- AGWKUHGLWHMYTG-UHFFFAOYSA-N
- SMILES
- C(O)COCCOCCOCCOCCOCCOCCOC
- CAS DataBase Reference
- 4437-01-8(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- HS Code
- 29094990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 41749
- Product name
- O-Methyl-heptaethylene glycol
- Purity
- ≥95% (oligomer purity)
- Packaging
- 1G
- Price
- $130.2
- Updated
- 2025/07/31
- Product number
- H1046
- Product name
- Heptaethylene Glycol Monomethyl Ether
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $108
- Updated
- 2025/07/31
- Product number
- H1046
- Product name
- Heptaethylene Glycol Monomethyl Ether
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $373
- Updated
- 2025/07/31
- Product number
- JK441840
- Product name
- Heptaethylene Glycol Monomethyl Ether
- Purity
- 97%
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- Y4948
- Product name
- Heptaethylene Glycol Monomethyl Ether
- Packaging
- 5g
- Price
- $359
- Updated
- 2021/12/16
Heptaethylene Glycol Monomethyl Ether Chemical Properties,Usage,Production
Description
m-PEG7-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization
Definition
The presence of heptaethylene glycol monomethyl ether (HGME) as a process impurity and degradation impurity in the final purified form of Benzonatate is a determining factor in establishing the safety, identity, strength, purity, and quality of the drug substance. Owing to the cutaneous toxicity of HGME in the BNZ drug substance, a suitable and selective analysis method is required for its quantitation[1].
reaction suitability
reagent type: cross-linking reagent
Synthesis
112-60-7
74654-05-0
4437-01-8
A 60% NaH dispersion in mineral oil was added in batches to a stirred solution of triacetylene glycol (35.7 mmol) in anhydrous DMF (25.7 mL) under nitrogen protection, and the mixture was stirred for 1 hour at room temperature. Subsequently, a solution of 2-(2-(2-methoxyethoxy)ethoxy)ethyl methanesulfonate (23.36 mmol) in anhydrous DMF (4 mL) was added in a single addition to the resulting salt, and stirring was continued for 3.5 hours at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC with 12% unfolding agent ratio). Upon completion of the reaction, the reaction mixture was diluted with an equal volume of 1N HCl, extracted with ethyl acetate (2 x 20 mL) and the organic phase discarded. The aqueous phase was extracted and post-treated to give heptaglycol monomethyl ether in 82-84% yield.
IC 50
PEGs
References
[1] Lakshmi Narasimha Rao Katakam, Vishnu Murthy Marisetti, Santhosh Kumar Ettaboina. “Development and validation of LC–MS method for the determination of heptaethylene glycol monomethyl ether in benzonatate bulk drugs.” Biomedical Chromatography 35 7 (2021).
Heptaethylene Glycol Monomethyl Ether Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Heptaethylene Glycol Monomethyl Ether manufacturers
- Product
- mPEG7-OH 4437-01-8
- Price
- US $4788.00/kg
- Min. Order
- 0.5kg
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-15
- Product
- 2,5,8,11,14,17,20-heptaoxadocosan-22-ol 4437-01-8
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-10
- Product
- HEPTAETHYLENE GLYCOL MONOMETHYL ETHER 4437-01-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30