ALX 5407 Hydrochloride

Product Name: ALX 5407 Hydrochloride
CAS No.: 200006-08-2
Chemical Name: ALX 5407 Hydrochloride
Synonyms: ALX 5407 HYDROCHLORIDE;(+/-)-NFPS HYDROCHLORIDE;(+/-)-NFPS HYDROCHLORIDE;N-[3-(4'-FLUOROPHENYL)-3-(4'-PHENYLPHENOXY)PROPYL]SARCOSINE HYDROCHLORIDE;(±)-NFPS hydrochloride, N-[3-(4μ-Fluorophenyl)-3-(4μ-phenylphenoxy)propyl]sarcosine hydrochloride
CBNumber: CB6363477
Molecular Formula: C24H25ClFNO3
Formula Weight: 429.91
MOL File: Mol file

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ALX 5407 Hydrochloride Property

storage temp.: 2-8°C
solubility: DMSO: ~16 mg/mL, soluble
form: solid
color: off-white

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 22-24/25-61-60
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0897
Product name: ALX 5407 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0897
Product name: ALX 5407 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $417
Updated: 2024/03/01

Tocris

Product number: 1757
Product name: ALX 5407 hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $212
Updated: 2021/12/16

TRC

Product number: A575815
Product name: ALX 5407 hydrochloride
Packaging: 1mg
Price: $195
Updated: 2021/12/16

Usbiological

Product number: 285122
Product name: NFPS hydrochloride
Packaging: 5mg
Price: $420
Updated: 2021/12/16

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ALX 5407 Hydrochloride Chemical Properties,Usage,Production

Uses

ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

Uses

ALX 5407 Hydrochloride can be used in the preparation of amino acid derivatives as pharmaceuticals for treatment of neurological and neuropsychiatric disorders.

Biochem/physiol Actions

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).

storage

Desiccate at +4°C

References

[1]. atkinson bn, bell sc, de vivo m, et al. alx 5407: a potent, selective inhibitor of the hglyt1 glycine transporter. mol pharmacol, 2001, 60(6):1414-20.

ALX 5407 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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ALX 5407 Hydrochloride Suppliers

Canada 1 CHINA 31 India 1 Switzerland 1 United Kingdom 2 United States 5 USA 1 Global 42

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
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Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
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Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
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Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30238
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DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
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MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
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200006-08-2, ALX 5407 HydrochlorideRelated Search:

SARCOSINE HYDROCHLORIDE

(+/-)-NFPS HYDROCHLORIDE

N-[3-(4'-FLUOROPHENYL)-3-(4'-PHENYLPHENOXY)PROPYL]SARCOSINE HYDROCHLORIDE

(±)-NFPS hydrochloride, N-[3-(4μ-Fluorophenyl)-3-(4μ-phenylphenoxy)propyl]sarcosine hydrochloride

ALX 5407 HYDROCHLORIDE

(+/-)-NFPS HYDROCHLORIDE

200006-08-2

C24H24NO3FHCl

Amino Acids & Derivatives

Aromatics

Intermediates & Fine Chemicals

Neurochemicals

Pharmaceuticals

Amino Acids & Derivatives, Aromatics, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals