ChemicalBook > CAS DataBase List > Tolfenamic acid

Tolfenamic acid

Product Name
Tolfenamic acid
CAS No.
13710-19-5
Chemical Name
Tolfenamic acid
Synonyms
CLOTAM;gea6414;Tolfedine;Tolfenamic;olfenamicaci;Toxamic acid;Tofenamic acid;TOLFENAMIC ACID;TOLEFNAMIC ACID;Tolfenamic acid CRS
CBNumber
CB6365693
Molecular Formula
C14H12ClNO2
Formula Weight
261.7
MOL File
13710-19-5.mol
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Tolfenamic acid Property

Melting point:
210-214°C
Boiling point:
405.4±40.0 °C(Predicted)
Density 
1.2037 (rough estimate)
refractive index 
1.5270 (estimate)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, soluble in dimethylformamide, sparingly soluble in ethanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
pka
3.66±0.36(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml).
Merck 
14,9513
InChIKey
YEZNLOUZAIOMLT-UHFFFAOYSA-N
CAS DataBase Reference
13710-19-5(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 2-[(3-chloro-2-methylphenyl)amino]- (13710-19-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
CB2687500
HazardClass 
6.1
PackingGroup 
III
HS Code 
29224919
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
34073
Product name
Tolfenamic acid
Purity
VETRANAL , analytical standard
Packaging
100mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1629
Product name
Tolfenamic acid
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$82.8
Updated
2022/05/15
TCI Chemical
Product number
C2064
Product name
N-(3-Chloro-2-methylphenyl)anthranilic Acid
Purity
>97.0%(T)
Packaging
25g
Price
$140
Updated
2024/03/01
Alfa Aesar
Product number
J61256
Product name
Tolfenamic acid, 99+%
Packaging
5g
Price
$67.65
Updated
2024/03/01
Alfa Aesar
Product number
J61256
Product name
Tolfenamic acid, 99+%
Packaging
10g
Price
$125.65
Updated
2024/03/01
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Tolfenamic acid Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

antiinflammatory, analgesia

Uses

Amidated GRF fragment equipotent to GRF in release of somatotropin from anterior pituitary

Uses

A non steroidal anti-inflammatory agent found to inhibit COX-2 isoenzymes

Uses

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.

Uses

Non-steroidal anti-inflammatory drugs (NSAIDs).

Definition

ChEBI: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.

General Description

Tolfenamic Acid is an anthranilic acid derivative and a non-steroidal anti-inflammatory drug (NSAID). Its applications in treating pancreatic, esophageal, colorectal and lung cancer is being investigated.

Biochem/physiol Actions

Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.

Clinical Use

NSAID:
Treatment of migraine

Synthesis

Tolfenamic acid is obtained by condensation of 2-chlorobenzoic acid with 3- chloro-2-methyl-phenylamine using CuBr2 in diethylenglycol dimethyl ether .

Veterinary Drugs and Treatments

Tolfenamic acid may be useful for the treatment of acute or chronic pain and/or inflammation in dogs and acute pain/inflammation in cats. In Europe, it is also approved for use in cattle.

Drug interactions

Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).
Antibacterials: possibly increased risk of convulsions with quinolones.
Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban.
Antidepressants: increased risk of bleeding with SSRIs and venlafaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin concentration.
Antivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavir.
Ciclosporin: may potentiate nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect; hyperkalaemia with potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity

Metabolism

Tolfenamic acid is metabolised in the liver; the metabolites and unchanged drug are conjugated with glucuronic acid. About 90
% of an ingested dose is excreted in the urine and the remainder in the faeces.

Tolfenamic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tolfenamic acid manufacturers

Hebei Dangtong Import and export Co LTD
Product
Tolfenamic acid 13710-19-5
Price
US $200.00-170.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20Tons
Release date
2023-10-09
Hebei Weibang Biotechnology Co., Ltd
Product
Tolfenamic acid 13710-19-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
Tolfenamic acid 13710-19-5
Price
US $40.00-7.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-15

13710-19-5, Tolfenamic acidRelated Search:


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