Tolfenamic acid
- Product Name
- Tolfenamic acid
- CAS No.
- 13710-19-5
- Chemical Name
- Tolfenamic acid
- Synonyms
- CLOTAM;gea6414;Tolfedine;Tolfenamic;olfenamicaci;Toxamic acid;Tofenamic acid;TOLFENAMIC ACID;TOLEFNAMIC ACID;Tolfenamic acid CRS
- CBNumber
- CB6365693
- Molecular Formula
- C14H12ClNO2
- Formula Weight
- 261.7
- MOL File
- 13710-19-5.mol
Tolfenamic acid Property
- Melting point:
- 210-214°C
- Boiling point:
- 405.4±40.0 °C(Predicted)
- Density
- 1.2037 (rough estimate)
- refractive index
- 1.5270 (estimate)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, soluble in dimethylformamide, sparingly soluble in ethanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
- pka
- 3.66±0.36(Predicted)
- color
- White to Off-White
- Water Solubility
- Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml).
- Merck
- 14,9513
- InChIKey
- YEZNLOUZAIOMLT-UHFFFAOYSA-N
- CAS DataBase Reference
- 13710-19-5(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 2-[(3-chloro-2-methylphenyl)amino]- (13710-19-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 34073
- Product name
- Tolfenamic acid
- Purity
- VETRANAL , analytical standard
- Packaging
- 100mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- PHR1629
- Product name
- Tolfenamic acid
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500mg
- Price
- $82.8
- Updated
- 2022/05/15
- Product number
- C2064
- Product name
- N-(3-Chloro-2-methylphenyl)anthranilic Acid
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $140
- Updated
- 2024/03/01
- Product number
- J61256
- Product name
- Tolfenamic acid, 99+%
- Packaging
- 5g
- Price
- $67.65
- Updated
- 2024/03/01
- Product number
- J61256
- Product name
- Tolfenamic acid, 99+%
- Packaging
- 10g
- Price
- $125.65
- Updated
- 2024/03/01
Tolfenamic acid Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
antiinflammatory, analgesia
Uses
Amidated GRF fragment equipotent to GRF in release of somatotropin from anterior pituitary
Uses
A non steroidal anti-inflammatory agent found to inhibit COX-2 isoenzymes
Uses
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.
Uses
Non-steroidal anti-inflammatory drugs (NSAIDs).
Definition
ChEBI: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.
General Description
Tolfenamic Acid is an anthranilic acid derivative and a non-steroidal anti-inflammatory drug (NSAID). Its applications in treating pancreatic, esophageal, colorectal and lung cancer is being investigated.
Biochem/physiol Actions
Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.
Clinical Use
NSAID:
Treatment of migraine
Synthesis
Tolfenamic acid is obtained by
condensation of 2-chlorobenzoic acid with 3-
chloro-2-methyl-phenylamine using CuBr2 in
diethylenglycol dimethyl ether .
Veterinary Drugs and Treatments
Tolfenamic acid may be useful for the treatment of acute or chronic pain and/or inflammation in dogs and acute pain/inflammation in cats. In Europe, it is also approved for use in cattle.
Drug interactions
Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists:
antagonism of hypotensive effect; increased risk of
nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more
NSAIDs, including aspirin (increased side effects);
avoid with ketorolac (increased risk of side effects
and haemorrhage).
Antibacterials: possibly increased risk of convulsions
with quinolones.
Anticoagulants: effects of coumarins and
phenindione enhanced; possibly increased risk of
bleeding with heparins, dabigatran and edoxaban.
Antidepressants: increased risk of bleeding with
SSRIs and venlafaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin
concentration.
Antivirals: increased risk of haematological toxicity
with zidovudine; concentration possibly increased by
ritonavir.
Ciclosporin: may potentiate nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate;
increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity;
antagonism of diuretic effect; hyperkalaemia with
potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity
Metabolism
Tolfenamic acid is metabolised in the liver; the metabolites and unchanged drug are conjugated with glucuronic acid. About 90
% of an ingested dose is excreted in the urine and the remainder in the faeces.
Tolfenamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from Tolfenamic acid manufacturers
- Product
- Tolfenamic acid 13710-19-5
- Price
- US $200.00-170.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20Tons
- Release date
- 2023-10-09
- Product
- Tolfenamic acid 13710-19-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-05-09
- Product
- Tolfenamic Acid 13710-19-5
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2024-04-09