3-CYANOBENZYLAMINE
- Product Name
- 3-CYANOBENZYLAMINE
- CAS No.
- 10406-24-3
- Chemical Name
- 3-CYANOBENZYLAMINE
- Synonyms
- AKOS BB-9335;3-CYANOBENZYLAMINE;M-CyanobenzylaMine;α-AMino-M-tolunitrile;1-AMinoMethyl-3-cyanobenzene;Benzonitrile, 3-(aminomethyl)-
- CBNumber
- CB6370969
- Molecular Formula
- C8H8N2
- Formula Weight
- 132.16
- MOL File
- 10406-24-3.mol
3-CYANOBENZYLAMINE Property
- Melting point:
- 102-103 °C
- Boiling point:
- 115 °C(Press: 1 Torr)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- liquid
- pka
- 8.56±0.10(Predicted)
- color
- Colourless
Safety
- RIDADR
- 2735
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C962295
- Product name
- 3-Cyanobenzylamine
- Packaging
- 250mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- C962295
- Product name
- 3-Cyanobenzylamine
- Packaging
- 2.5g
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- CHM0094004
- Product name
- 3-CYANOBENZYLAMINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1473.14
- Updated
- 2021/12/16
- Product number
- X8692
- Product name
- 3-Cyanobenzylamine
- Packaging
- 5g
- Price
- $268
- Updated
- 2021/12/16
- Product number
- CHM0094004
- Product name
- 3-CYANOBENZYLAMINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $983.52
- Updated
- 2021/12/16
3-CYANOBENZYLAMINE Chemical Properties,Usage,Production
Uses
3-Cyanobenzylamine is used in the preparation of indole and indazole derivatives as orexin receptor antagonists.
Synthesis
328552-90-5
10406-24-3
3-Azidomethyl-benzenecarbonitrile (12.4 g, 0.078 mol) was used as a raw material and dissolved in ethyl acetate (40 mL). To this solution was added 5% palladium-carbon catalyst (4.0 g) at room temperature and the hydrogenation reaction was carried out overnight under 45 psi hydrogen pressure. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst. Subsequently, the solvent in the filtrate was evaporated to afford 3-aminomethyl-benzenecarbonitrile as a light brown solid (7.87 g, 76% yield). The product was characterized by 1H-NMR (CDCl3): δ 7.62-7.57 (m, 1H), 7.56-7.43 (m, 2H), 7.42-7.31 (m, 1H), 3.87 (s, 2H).
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 3, p. 1067 - 1088
[2] Patent: WO2016/7966, 2016, A2. Location in patent: Paragraph 0031
[3] Patent: US2006/94749, 2006, A1. Location in patent: Page/Page column 11
[4] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 20, p. 3477 - 3482
3-CYANOBENZYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CYANOBENZYLAMINE Suppliers
- Tel
- --
- Fax
- --
- akos@akosgmbh.de
- Country
- Germany
- ProdList
- 6717
- Advantage
- 72
View Lastest Price from 3-CYANOBENZYLAMINE manufacturers
- Product
- 3-CYANOBENZYLAMINE 10406-24-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 3-CYANOBENZYLAMINE 10406-24-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 3-CYANOBENZYLAMINE 10406-24-3
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg；10kg; 25kg
- Release date
- 2020-01-07