2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

Product Name: 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide
CAS No.: 1099592-35-4
Chemical Name: 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide
Synonyms: NASH;NSAH, 10 mM in DMSO;Naphthyl salicylic acyl hydrazone;(E)-2-Hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide;DNA/RNA Synthesis,HCT116,MDA-231,Panc1,Inhibitor,NSAH,inhibit,S-phase;2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide;Benzoic acid, 2-hydroxy-, (2E)-2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide
CBNumber: CB63715947
Molecular Formula: C18H14N2O3
Formula Weight: 306.32
MOL File: 1099592-35-4.mol

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2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide Property

storage temp.: Store at -20°C
solubility: DMSO : 62.5 mg/mL (204.03 mM; Need ultrasonic)
form: Solid
color: Light yellow to yellow
InChI: InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+
InChIKey: ZZSJOLDICPVVAV-YBFXNURJSA-N
SMILES: C(N/N=C/C1=C2C(C=CC=C2)=CC=C1O)(=O)C1=CC=CC=C1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2537
Product name: NSAH
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $71.86
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2537
Product name: NSAH
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $171.5
Updated: 2025/07/31

ChemScene

Product number: CS-0063330
Product name: NSAH
Purity: 98.62%
Packaging: 25mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0063330
Product name: NSAH
Purity: 98.62%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0063330
Product name: NSAH
Purity: 98.62%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

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2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide Chemical Properties,Usage,Production

Uses

NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].

Biological Activity

NSAH is a cell penetrant, potent and selective nonnucleoside reversible inhibitor of large subunit (hRRM1) of hRR (human ribonucleotide reductase). NSAH binds to catalytic site of hRRM1. It inhibits hRR in cells. NSAH exhibit potent cytotoxicity toward cancer cells, while demonstrated very moderate toxicity against normal blood progenitor cells.

References

[1] Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246. DOI:10.1073/pnas.1620220114

2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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1099592-35-4, 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazideRelated Search:

2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

Naphthyl salicylic acyl hydrazone

Benzoic acid, 2-hydroxy-, (2E)-2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide

(E)-2-Hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide

NASH

DNA/RNA Synthesis,HCT116,MDA-231,Panc1,Inhibitor,NSAH,inhibit,S-phase

NSAH, 10 mM in DMSO

1099592-35-4