4,6-DICHLORONICOTINONITRILE
- Product Name
- 4,6-DICHLORONICOTINONITRILE
- CAS No.
- 166526-03-0
- Chemical Name
- 4,6-DICHLORONICOTINONITRILE
- Synonyms
- EOS-61391;4,6-DICHLORONICOTINONITRILE;3-Cyano-4,6-dichloropyridine;4,6-Dichloronicotinonitrile 98%;4,6-Dichloro-3-pyridinecarbonitrile;4,6-dichloropyridine-3-carbonitrile;3-Pyridinecarbonitrile, 4,6-dichloro-
- CBNumber
- CB6384900
- Molecular Formula
- C6H2Cl2N2
- Formula Weight
- 173
- MOL File
- 166526-03-0.mol
4,6-DICHLORONICOTINONITRILE Property
- Melting point:
- 133-135°
- Boiling point:
- 272.9±35.0℃ (760 Torr)
- Density
- 1.49±0.1 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 118.8±25.9℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.94±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H2Cl2N2/c7-5-1-6(8)10-3-4(5)2-9/h1,3H
- InChIKey
- VNRGFXKFARXGSX-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC(Cl)=C1C#N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- D435348
- Product name
- 4,6-Dichloronicotinonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D435348
- Product name
- 4,6-Dichloronicotinonitrile
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD45414
- Product name
- 4,6-Dichloronicotinonitrile
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD45414
- Product name
- 4,6-Dichloronicotinonitrile
- Packaging
- 10g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- OR303715
- Product name
- 4,6-Dichloronicotinonitrile
- Purity
- 98%
- Packaging
- 25g
- Price
- $240
- Updated
- 2021/12/16
4,6-DICHLORONICOTINONITRILE Chemical Properties,Usage,Production
Uses
4, 6-dichlorotinonitrile is a nitrile organic compound, which can be used as pharmaceutical intermediates.
Synthesis
70593-57-6
166526-03-0
General procedure for the synthesis of 4,6-dichloronicotinonitrile from 4,6-dichloropyridine-3-amide: Pyridine (20.3 mL, 250 mmol) was slowly added to an acetonitrile (180 mL) suspension of 4,6-dichloronicotinamide (8.00 g, 41.9 mmol) at room temperature. Subsequently, phosphorous trichloride (11.7 mL, 126 mmol) was added dropwise over 3 minutes. The reaction mixture was heated to 60 °C with continuous stirring for 1.5 hours. Upon completion of the reaction, the solution was cooled to room temperature and carefully poured into 0.8 M aqueous sodium hydroxide solution (600 mL). Multiple extractions were performed with ethyl acetate (6 x 400 mL) and the organic phases were combined. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel fast column chromatography (30% ethyl acetate/hexane as eluent) to afford 4,6-dichloronicotinonitrile as a light orange solid (6.41 g, 88% yield).1H NMR (400 MHz, CDCl3) δ 8.67 (s, 1H), 7.58 (s, 1H).
References
[1] Patent: US2015/291629, 2015, A1. Location in patent: Paragraph 1175
4,6-DICHLORONICOTINONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-DICHLORONICOTINONITRILE manufacturers
- Product
- 4,6-DICHLORONICOTINONITRILE 166526-03-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-06
- Product
- 4,6-DICHLORONICOTINONITRILE 166526-03-0
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 4,6-DICHLORONICOTINONITRILE 166526-03-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2023-03-19