4,6-Dichloronicotinic acid
- Product Name
- 4,6-Dichloronicotinic acid
- CAS No.
- 73027-79-9
- Chemical Name
- 4,6-Dichloronicotinic acid
- Synonyms
- 4,6-DichloronicotinicAci;4,6-DICHLORONICOTINIC ACID;2,4-Dichloro-5-carboxypyridine;2,4-DICHLORO-5-CARBOXYLPYRIDINE;4,6-Dichloronicotinic acid ,97%;2,4-Dichloro-5-carboxylpyridine ,97%;4,6-Dichloronicotinic Acid(WX614282);4,6-Dichloropyridin-3-carboxylic acid;2,4-Dichloro-5-pyridinecarboxylic acid;4,6-DICHLOROPYRIDINE-3-CARBOXYLIC ACID
- CBNumber
- CB5449682
- Molecular Formula
- C6H3Cl2NO2
- Formula Weight
- 192
- MOL File
- 73027-79-9.mol
4,6-Dichloronicotinic acid Property
- Melting point:
- 158-160
- Boiling point:
- 337.0±37.0 °C(Predicted)
- Density
- 1.612±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 1.87±0.25(Predicted)
- form
- Solid
- color
- White to Light yellow
- Water Solubility
- Slightly soluble in water.
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C6H3Cl2NO2/c7-4-1-5(8)9-2-3(4)6(10)11/h1-2H,(H,10,11)
- InChIKey
- ILMIEWNDXAKVNI-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC(Cl)=C1C(O)=O
- CAS DataBase Reference
- 73027-79-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-20/21/22
- Safety Statements
- 24/25-36/37
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D5311
- Product name
- 4,6-Dichloronicotinic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- D5311
- Product name
- 4,6-Dichloronicotinic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $118
- Updated
- 2025/07/31
- Product number
- D435638
- Product name
- 4,6-Dichloronicotinic Acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD52890
- Product name
- 4,6-Dichloronicotinic acid
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 062528
- Product name
- 4,6-Dichloronicotinic Acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
4,6-Dichloronicotinic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
4,6-Dichloronicotinic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.
Synthesis
40296-46-6
73027-79-9
General procedure for the synthesis of 4,6-dichloronicotinic acid from ethyl 4,6-dichloronicotinate: to a stirred solution of ethyl 4,6-dichloronicotinate (22) (25.95 g, 118 mmol) dissolved in 4:1:1 THF:MeOH:water (600 mL) was added sodium hydroxide solution (40 mL, 6.25 M). After 30 min of reaction, the reaction mixture was acidified to pH 2 with concentrated hydrochloric acid and subsequently diluted with 1:1 EtOAc:Et2O and washed sequentially with water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated. The resulting off-white solid was purified by concentrating twice from toluene to give the final target product 4,6-dichloronicotinic acid (23) as a white solid (21.73 g, 96% yield).
References
[1] Patent: US2005/49419, 2005, A1. Location in patent: Page/Page column 24
[2] Patent: US2005/54701, 2005, A1
[3] Tetrahedron Letters, 2011, vol. 52, # 4, p. 512 - 514
[4] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 229-230
[5] Patent: US2015/191464, 2015, A1. Location in patent: Paragraph 0611
4,6-Dichloronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-Dichloronicotinic acid manufacturers
- Product
- 4,6-Dichloronicotinic acid 73027-79-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-27
- Product
- 4,6-Dichloronicotinic acid 73027-79-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- 4,6-Dichloronicotinic acid 73027-79-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-10