6-Chloronicotinic acid
- Product Name
- 6-Chloronicotinic acid
- CAS No.
- 5326-23-8
- Chemical Name
- 6-Chloronicotinic acid
- Synonyms
- 2－chloro－5－pyrdinecarboxylic acid;6-CHLOROPYRIDINE-3-CARBOXYLIC ACID;2-chloropyridine-5-carboxylic acid;6-ChL;6-Chloronicoti;TIMTEC-BB SBB004004;RARECHEM AL BO 0729;6 - chlorine niacin;6-Chloronicotinic ac;2-Chloroncotinic acid
- CBNumber
- CB4707499
- Molecular Formula
- C6H4ClNO2
- Formula Weight
- 157.55
- MOL File
- 5326-23-8.mol
6-Chloronicotinic acid Property
- Melting point:
- 190 °C (dec.)(lit.)
- Boiling point:
- 241.15°C (rough estimate)
- Density
- 0.5
- refractive index
- 1.5870 (estimate)
- Flash point:
- 192°C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- deionized water: soluble
- form
- Crystalline Powder
- pka
- 3.24±0.10(Predicted)
- color
- Off-white to beige
- Water Solubility
- Soluble in water (2 mg/ml at 20°C), ethanol, methanol, DMSO, and slightly soluble in chloroform.
- Decomposition
- 192 ºC
- BRN
- 115993
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- UAWMVMPAYRWUFX-UHFFFAOYSA-N
- CAS DataBase Reference
- 5326-23-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 6-Chloronicotinic acid(5326-23-8)
- EPA Substance Registry System
- 6-Chloronicotinic acid (5326-23-8)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25-37/39
- WGK Germany
- 3
- TSCA
- T
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 156353
- Product name
- 6-Chloropyridine-3-carboxylic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $45.7
- Updated
- 2024/03/01
- Product number
- 156353
- Product name
- 6-Chloropyridine-3-carboxylic acid
- Purity
- 99%
- Packaging
- 25g
- Price
- $57.4
- Updated
- 2024/03/01
- Product number
- C1116
- Product name
- 6-Chloronicotinic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $92
- Updated
- 2024/03/01
- Product number
- C1116
- Product name
- 6-Chloronicotinic Acid
- Purity
- >98.0%(T)
- Packaging
- 100g
- Price
- $274
- Updated
- 2024/03/01
- Product number
- A15620
- Product name
- 6-Chloronicotinic acid, 99%
- Packaging
- 5g
- Price
- $35.65
- Updated
- 2024/03/01
6-Chloronicotinic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white to beige crystalline powder
Uses
6-Chloronicotinic acid is used as building block for different chemical synthesis. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.
Uses
6-Chloropyridine-3-carboxylic acid (6-chloronicotinic acid/6-CNA) has been used to study its photolytic and photocatalytic degradation. 6-CNA is a degradation product of neonicotinoid insecticides imidacloprid and acetamiprid and is known to appear in different environmental matrices. The product has been used as a media component during the isolation of 6-CNA degrading bacterial strain from imidacloprid-exposed soil samples.
Definition
ChEBI: 6-Chloronicotinic acid is a member of pyridines and an aromatic carboxylic acid.
General Description
6-Chloropyridine-3-carboxylic acid is a metabolite of the neonicotinoid pesticides, imidacloprid and acetamiprid and occurs in different environmental matrices.(3) It is widely used in agricultural crop protection, domestic insect control and environmental pest management.
Synthesis
In a 1000ml flask, add 450g chlorobenzene, 100g 2-chloro-5-methylpyridine, and 3g catalyst cobalt acetate under stirring, heat the system to 80℃, introduce oxygen, and control the oxygen flow rate at 0.4L/min. React under this condition for 4 hours. After the reaction, cool the system to room temperature, filter, and dry to obtain a mixture of 119g 6-chloronicotinic acid and cobalt acetate. Place those mentioned above mixed crude product in a 1000ml flask, add 600g of recrystallization solvent methanol, stir and heat to reflux; wait for the 6-chloronicotinic acid crude product to dissolve completely, keep warm for 5min, slowly cool the system to 5℃, precipitate a white product, maintain this internal temperature and continue stirring for 1 hour, filter, wash the filter cake once with a small amount of cooled methanol, and dry the obtained damp product at 80℃ for 4 hours to obtain 98.5g 6-chloronicotinic acid, purity 99.52% (HPLC), yield 79.7%.
Purification Methods
Purify it by recrystallisation from hot H2O and sublime it in a vacuum. [Pechmann & Welsch Chem Ber 17 2384 1884, Herz & Murty J Org Chem 26 122 1961, Beilstein 22/2 V 177.]
6-Chloronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloronicotinic acid manufacturers
- Product
- 6-Chloronicotinic Acid 5326-23-8
- Price
- US $10.70/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20
- Product
- 6-Chloronicotinic acid 5326-23-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-07-26
- Product
- 6-Chloronicotinic acid 5326-23-8
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22