6-Chloronicotinic acid

Product Name: 6-Chloronicotinic acid
CAS No.: 5326-23-8
Chemical Name: 6-Chloronicotinic acid
Synonyms: 2－chloro－5－pyrdinecarboxylic acid;6-CHLOROPYRIDINE-3-CARBOXYLIC ACID;2-chloropyridine-5-carboxylic acid;6-ChL;6-Chloronicoti;TIMTEC-BB SBB004004;RARECHEM AL BO 0729;6 - chlorine niacin;6-Chloronicotinic ac;2-Chloroncotinic acid
CBNumber: CB4707499
Molecular Formula: C6H4ClNO2
Formula Weight: 157.55
MOL File: 5326-23-8.mol

More

Less

6-Chloronicotinic acid Property

Melting point:: 190 °C (dec.)(lit.)
Boiling point:: 241.15°C (rough estimate)
Density: 0.5
refractive index: 1.5870 (estimate)
Flash point:: 192°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: deionized water: soluble
form: Crystalline Powder
pka: 3.24±0.10(Predicted)
color: Off-white to beige
Water Solubility: Soluble in water (2 mg/ml at 20°C), ethanol, methanol, DMSO, and slightly soluble in chloroform.
Decomposition: 192 ºC
BRN: 115993
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: UAWMVMPAYRWUFX-UHFFFAOYSA-N
CAS DataBase Reference: 5326-23-8(CAS DataBase Reference)
NIST Chemistry Reference: 6-Chloronicotinic acid(5326-23-8)
EPA Substance Registry System: 6-Chloronicotinic acid (5326-23-8)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25-37/39
WGK Germany: 3
TSCA: T
HazardClass: IRRITANT
HS Code: 29333999

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 156353
Product name: 6-Chloropyridine-3-carboxylic acid
Purity: 99%
Packaging: 5g
Price: $45.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 156353
Product name: 6-Chloropyridine-3-carboxylic acid
Purity: 99%
Packaging: 25g
Price: $57.4
Updated: 2024/03/01

TCI Chemical

Product number: C1116
Product name: 6-Chloronicotinic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $92
Updated: 2024/03/01

TCI Chemical

Product number: C1116
Product name: 6-Chloronicotinic Acid
Purity: >98.0%(T)
Packaging: 100g
Price: $274
Updated: 2024/03/01

Alfa Aesar

Product number: A15620
Product name: 6-Chloronicotinic acid, 99%
Packaging: 5g
Price: $35.65
Updated: 2024/03/01

More

Less

6-Chloronicotinic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white to beige crystalline powder

Uses

6-Chloronicotinic acid is used as building block for different chemical synthesis. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.

Uses

6-Chloropyridine-3-carboxylic acid (6-chloronicotinic acid/6-CNA) has been used to study its photolytic and photocatalytic degradation. 6-CNA is a degradation product of neonicotinoid insecticides imidacloprid and acetamiprid and is known to appear in different environmental matrices. The product has been used as a media component during the isolation of 6-CNA degrading bacterial strain from imidacloprid-exposed soil samples.

Definition

ChEBI: 6-Chloronicotinic acid is a member of pyridines and an aromatic carboxylic acid.

General Description

6-Chloropyridine-3-carboxylic acid is a metabolite of the neonicotinoid pesticides, imidacloprid and acetamiprid and occurs in different environmental matrices.(3) It is widely used in agricultural crop protection, domestic insect control and environmental pest management.

Synthesis

In a 1000ml flask, add 450g chlorobenzene, 100g 2-chloro-5-methylpyridine, and 3g catalyst cobalt acetate under stirring, heat the system to 80℃, introduce oxygen, and control the oxygen flow rate at 0.4L/min. React under this condition for 4 hours. After the reaction, cool the system to room temperature, filter, and dry to obtain a mixture of 119g 6-chloronicotinic acid and cobalt acetate. Place those mentioned above mixed crude product in a 1000ml flask, add 600g of recrystallization solvent methanol, stir and heat to reflux; wait for the 6-chloronicotinic acid crude product to dissolve completely, keep warm for 5min, slowly cool the system to 5℃, precipitate a white product, maintain this internal temperature and continue stirring for 1 hour, filter, wash the filter cake once with a small amount of cooled methanol, and dry the obtained damp product at 80℃ for 4 hours to obtain 98.5g 6-chloronicotinic acid, purity 99.52% (HPLC), yield 79.7%.

Purification Methods

Purify it by recrystallisation from hot H2O and sublime it in a vacuum. [Pechmann & Welsch Chem Ber 17 2384 1884, Herz & Murty J Org Chem 26 122 1961, Beilstein 22/2 V 177.]

6-Chloronicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE 6-MORPHOLINONICOTINOYL CHLORIDE 6-MORPHOLINONICOTINIC ACID 2-chloro-5-cyanopyridine 6-PHENOXYNICOTINIC ACID 6-PHENOXYNICOTINONITRILE 6-PHENOXYNICOTINOYL CHLORIDE

More

Less

6-Chloronicotinic acid Suppliers

Americas 1 Belgium 2 Canada 3 China 486 Europe 3 France 1 Germany 13 India 49 Ireland 1 Japan 9 Slovakia 1 South Korea 1 Switzerland 6 Ukraine 2 United Kingdom 16 United States 67 Global 661

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

GLR Innovations

Tel: +91 9891111994
Email: info@glrgroup.in
Country: India
ProdList: 4535
Advantage: 58

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

Manus Aktteva Biopharma LLP

Tel: --
Fax: --
Email: products@manusakttevabiopharma.in
Country: India
ProdList: 275
Advantage: 58

Corey Organics Private Limited

Tel: --
Fax: --
Email: admin@coreyorganics.com
Country: India
ProdList: 51
Advantage: 58

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: India
ProdList: 6905
Advantage: 58

Ms Life Sciences

Tel: --
Fax: --
Country: India
ProdList: 341
Advantage: 58

Corey Organics Private Ltd.

Tel: --
Fax: --
Email: nfo@coreyorganics.com
Country: India
ProdList: 210
Advantage: 58

Sakam Finechem Pvt., Ltd.

Tel: --
Fax: --
Email: info@sakamfinechem.com
Country: India
ProdList: 556
Advantage: 58

ASM Organics

Tel: --
Fax: --
Country: India
ProdList: 1185
Advantage: 58

Vital Synthetic Labs Pvt., Ltd.

Tel: --
Fax: --
Email: info@vitalsynthetics.in
Country: India
ProdList: 271
Advantage: 58

HiMedia Laboratories

Tel: --
Fax: --
Email: o@himedialabs.com
Country: India
ProdList: 1841
Advantage: 58

V Indaf Overseas Pvt., Ltd.

Tel: --
Fax: --
Email: info@vindaf.com
Country: India
ProdList: 117
Advantage: 58

Azole Rasayanas India Private Limited

Tel: --
Fax: --
Email: info@azolerasayanas.com
Country: India
ProdList: 681
Advantage: 58

Oceanic Pharmachem Pvt. Ltd.

Tel: --
Fax: --
Email: info@oceanicpharmachem.com
Country: India
ProdList: 2005
Advantage: 58

ARR Life Sciences

Tel: --
Fax: --
Email: info@arrlifesciences.com
Country: India
ProdList: 18
Advantage: 58

Saradhi Organics

Tel: --
Fax: --
Email: sales@saradhiorganics.com
Country: India
ProdList: 183
Advantage: 58

VASIN BIO LIFE SCIENCES PVT LTD

Tel: --
Fax: --
Email: info@vasinbio.com
Country: India
ProdList: 2092
Advantage: 58

Chemit Laboratories

Tel: --
Fax: --
Country: India
ProdList: 287
Advantage: 58

Aggarwal Mercantiles

Tel: --
Fax: --
Country: India
ProdList: 63
Advantage: 58

Prodev Pharma (OPC) Pvt Ltd

Tel: --
Fax: --
Email: bd@prodevpharma.in
Country: India
ProdList: 38
Advantage: 58

Reax Chemicals

Tel: --
Fax: --
Country: India
ProdList: 4217
Advantage: 58

Anand Agencies

Tel: --
Fax: --
Email: en@gmail.com
Country: India
ProdList: 2332
Advantage: 58

Avra Synthesis Pvt Ltd

Tel: --
Fax: --
Email: info@avrasynthesis.com
Country: India
ProdList: 1603
Advantage: 30

Molecraft LifeSciences Pvt Ltd

Tel: --
Fax: --
Email: info@molecraft.com
Country: India
ProdList: 757
Advantage: 0

Rivashaa Agrotech Biopharma Pvt. Ltd.

Tel: --
Fax: --
Email: source@rivashaa.com
Country: India
ProdList: 986
Advantage: 58

Aggarwal Supplier

Tel: --
Fax: --
Country: India
ProdList: 6
Advantage: 58

Indian Chemical Company

Tel: --
Fax: --
Country: India
ProdList: 7
Advantage: 58

Aggarwal Traders

Tel: --
Fax: --
Country: India
ProdList: 12
Advantage: 58

Jubilant Infrastructure Limited

Tel: --
Fax: --
Email: Anuja.Parihar@jubl.com
Country: India
ProdList: 285
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

SL Drugs and Pharmaceuticals Pvt. Ltd.

Tel: --
Fax: --
Email: enquiry@sldrugs.com
Country: India
ProdList: 2683
Advantage: 50

S.R.LABORATORIES

Tel: --
Fax: --
Email: S.R.LABORATOREES@GMAIL.COM
Country: India
ProdList: 148
Advantage: 30

CHEMSWORTH

Tel: --
Fax: --
Email: info@chemsworth.com
Country: India
ProdList: 6700
Advantage: 30

OCEAN TRADING CORPORATION

Tel: --
Fax: --
Email: otcchem@otcchem.com
Country: India
ProdList: 6202
Advantage: 58

More

Less

View Lastest Price from 6-Chloronicotinic acid manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 6-Chloronicotinic Acid 5326-23-8
Price: US $10.70/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

Hebei Weibang Biotechnology Co., Ltd

Product: 6-Chloronicotinic acid 5326-23-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-07-26

Henan Fengda Chemical Co., Ltd

Product: 6-Chloronicotinic acid 5326-23-8
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-22

5326-23-8, 6-Chloronicotinic acidRelated Search:

Isonicotinic acid Ethyl 2-(Chlorosulfonyl)acetate Xanthinol nicotinate Inositol nicotinate 2-Hydroxy-5-pyridinecarboxylic acid 2,6-Dichloro-5-fluoronicotinic acid 3,4,5-Trifluorobenzaldehyde 5,6-Dichloronicotinic acid 6-CHLORO-4-ETHOXYNICOTINIC ACID Ethyl 4,6-dichloronicotinate 2,6-Dichloronicotinic acid 6-Chloronicotinic acid methyl ester C7H6ClNO2,6-CHLORONICOTINIC ACID METHYL ESTER Difluorochloromethane 4,6-Dichloronicotinic acid 2-Amino-5-chloropyridine-3-carboxylic acid 5-BROMO-6-CHLORONICOTINIC ACID METHYL ESTER Ethyl 6-chloronicotinate METHYL 5,6-DICHLORONICOTINATE

RARECHEM AL BO 0729

TIMTEC-BB SBB004004

3-Pyridinecarboxylic acid, 6-chloro-

6-chloro-3-pyridinecarboxylicaci

6-CHLORONICOTINIC ACID

6-CHLORO-3-PYRIDINECARBOXYLIC ACID

6-Chloronicotinic acid, 99% 25GR

6-Chloronicotinic acid, 99% 5GR

2-chloro-5-pyridincarboxylic acid

2-chloro-5-pyridineforMic acid

6-chloro-3-pyridincarboxylic acid

6-chloro-3-pyridineforMic acid

6-Chloropyridine-3-carboxylic acid, 5-Carboxy-2-chloropyridine

6-Chloronicotiinic acid

6-Chloro nicotintic acid

6-Chloropyridine-3-carboxylic acid 99%

6 - chlorine niacin

6-Chloronicoti

6-Chloronicotinic acid,100ppm

2-Chloroncotinic acid

6-ChL

6-CHLOROPYRIDINE-3-CARBOXYLIC ACID

6-Chloronicotinicacid,99%

6-chloro-3-carboxylic acid

6-Cholre Nicotinic Acid

6-Chloronicotinic acid 98%

6-CHLORO-3-PYRIDINECARBOXYLIC ACID / 6-CHLORONICOTINIC ACID

6-CHLORO NICOTINIC ACID 6-CHLORO NICOTINIC ACID

6-Chloronicotinic acid, 6-Chloropyridine-3-carboxylic acid

3-Carboxy-6-chloropyridine

6-Chloronicotinic acid ,97%

2－chloro－5－pyrdinecarboxylic acid

6-Chloropyridine-3-carboxylic acid,6-Chloronicotinic acid

2-chloropyridine-5-carboxylic acid

6-Chloronicotinic ac

6-Chloronicotinic acid Solution

6-Chloropyridine-3-carboxylic acid@100 μg/mL in Methanol

[carbonyl-14C1]-6-chloronicotinic acid

6-Chloronicotinic Acid Standard

6-Chloropyridine-3-carboxylic acid@1000 μg/mL in Acetonitrile

6-Chloronicotinic Acid &gt

6-Chloronicotinic acid (6-CNA)

6-Chloronicotinic acid USP/EP/BP

Imidacloprid Impurity 14

TIANFUCHEM--5326-23-8--High purity 6-Chloronicotinic acid factory price

2-Chloro pyidine-5-carboxylic acid

6-Chloronicotinic acid Solution in Methanol

6-Chloronicotinic acid 100 μg/ml Acetonitrile

5326-23-8

5236-23-8

Building Blocks

Halopyridines

Chloropyridines

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

pyridine series

Picolinic acid series