5,6-Dichloronicotinic acid
- Product Name
- 5,6-Dichloronicotinic acid
- CAS No.
- 41667-95-2
- Chemical Name
- 5,6-Dichloronicotinic acid
- Synonyms
- 2,3-dichloropyridine-5-carboxylic acid;5,6-DichL;5,6-Dichloro;TIMTEC-BB SBB003623;Avatrhopal Impurity 45;5,6-DICHLORONICOTINIC A;Avatrombopag Impurity 10;5,6-Dichloronicotinicaci;Avatroposide impurities16;5,6-DICHLORONICOTINIC ACID
- CBNumber
- CB5261891
- Molecular Formula
- C6H3Cl2NO2
- Formula Weight
- 192
- MOL File
- 41667-95-2.mol
5,6-Dichloronicotinic acid Property
- Melting point:
- 164-168 °C(lit.)
- Boiling point:
- 342.1±37.0 °C(Predicted)
- Density
- 1.612±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 2.87±0.10(Predicted)
- form
- Powder
- color
- White to beige to tan
- BRN
- 383740
- InChI
- InChI=1S/C6H3Cl2NO2/c7-4-1-3(6(10)11)2-9-5(4)8/h1-2H,(H,10,11)
- InChIKey
- RNRLTTNKVLFZJS-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C(Cl)C=C1C(O)=O
- CAS DataBase Reference
- 41667-95-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
N-Bromosuccinimide Price
- Product number
- 340219
- Product name
- 5,6-Dichloropyridine-3-carboxylic acid
- Purity
- 96%
- Packaging
- 5g
- Price
- $26
- Updated
- 2023/06/20
- Product number
- D2401
- Product name
- 5,6-Dichloronicotinic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- D2401
- Product name
- 5,6-Dichloronicotinic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $172
- Updated
- 2025/07/31
- Product number
- D435653
- Product name
- 5,6-Dichloronicotinic Acid
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- D435653
- Product name
- 5,6-Dichloronicotinic Acid
- Packaging
- 2.5g
- Price
- $60
- Updated
- 2021/12/16
5,6-Dichloronicotinic acid Chemical Properties,Usage,Production
Chemical Properties
white to off-white crystalline powder
Uses
5,6-Dichloronicotinic acid is a dihalonicotinic acid. It is used in the preparation of 5-chloro-6-iodonicotinic acid by iodine displacement.
Application
5,6-Dichloronicotinic acid is a compound that can be synthesized by reacting methyl ketones with chloroacetic acid. It is used in the synthesis of maleic anhydride and has been shown to inhibit the catalysis of acetylcholine chloride. It has also been shown to have an inhibitory effect on Alzheimer's disease. The kinetic mechanism for this inhibition occurs through the hydrolysis step of 5,6-Dichloronicotinic acid by magnesium chloride in hexane solution. The reactive acylation reaction proceeds when it reacts with acetic anhydride in the presence of pyridine.
Synthesis
401566-69-6
41667-95-2
The general procedure for the synthesis of 5,6-dichloropyridine-3-carboxylic acid from 5,6-dichloronicotinic acid ethyl ester was as follows: in a solvent mixture of tetrahydrofuran (THF), methanol (MeOH) and water (50 mL, 4:1:1, v/v/v), ethyl 5,6-dichloronicotinic acid ethyl ester (1.0 g, 4.5 mmol) and aqueous sodium hydroxide 2N solution (6.75 mL, 13.5 mmol). The reaction mixture was stirred at room temperature for 0.5 hours. Upon completion of the reaction, the mixture was concentrated to remove the organic solvent. Subsequently, the mixture was acidified with 2N hydrochloric acid to a pH of about 2. The acidified mixture was extracted with ether (30 mL x 3). The organic layers were combined, washed with water (50 mL x 3), dried over anhydrous sodium sulfate, and concentrated to give 5,6-dichloropyridine-3-carboxylic acid (800 mg, 91% yield) as a white solid.LCMS (ESI) m/z: 192.0 [M + H]+.
References
[1] Patent: US2013/317000, 2013, A1. Location in patent: Paragraph 0368-0369
5,6-Dichloronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,6-Dichloronicotinic acid manufacturers
- Product
- 5,6-Dichloronicotinic acid 41667-95-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-06
- Product
- 5,6-Dichloronicotinic acid 41667-95-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-26
- Product
- 5,6-Dichloronicotinic acid 41667-95-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ≥98% by HPLC
- Supply Ability
- 50kg/month
- Release date
- 2023-01-05