2,6-Dichloro-5-fluoronicotinic acid
- Product Name
- 2,6-Dichloro-5-fluoronicotinic acid
- CAS No.
- 82671-06-5
- Chemical Name
- 2,6-Dichloro-5-fluoronicotinic acid
- Synonyms
- 2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXYLIC ACID;2,6-Dichloro-5-Fluoronicotinic;2,6-DICHLORO-5-FLUORO-3-PYRIDINECARBOXYLIC ACID;RARECHEM AL BO 0975;TIMTEC-BB SBB003450;Fluorine chlorine niacin;Tosufloxacin tosilate Impurity 4;2,6-Dichloro-5-fluoronicotic acid;2,6-Dichloro-5-Fluoronicotinic API;2,6-Dichloro-5-fluoronictonic acid
- CBNumber
- CB3189052
- Molecular Formula
- C6H2Cl2FNO2
- Formula Weight
- 209.99
- MOL File
- 82671-06-5.mol
2,6-Dichloro-5-fluoronicotinic acid Property
- Melting point:
- 152-155 °C (lit.)
- Boiling point:
- 247°C (rough estimate)
- Density
- 1.6207 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 1.38±0.32(Predicted)
- color
- White to Yellow to Orange
- BRN
- 4311035
- InChI
- InChI=1S/C6H2Cl2FNO2/c7-4-2(6(11)12)1-3(9)5(8)10-4/h1H,(H,11,12)
- InChIKey
- LTDGKGCHRNNCAC-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C(F)C=C1C(O)=O
- CAS DataBase Reference
- 82671-06-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D2610
- Product name
- 2,6-Dichloro-5-fluoronicotinic Acid
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- D2610
- Product name
- 2,6-Dichloro-5-fluoronicotinic Acid
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- D437088
- Product name
- 2,6-Dichloro-5-fluoronicotinic Acid
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- D437088
- Product name
- 2,6-Dichloro-5-fluoronicotinic Acid
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 011229
- Product name
- 2,6-Dichloro-5-fluoronicotinic acid
- Purity
- 96%
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
2,6-Dichloro-5-fluoronicotinic acid Chemical Properties,Usage,Production
Chemical Properties
light yellow to beige fine crystalline powder
Uses
2,6-Dichloro-5-fluoronicotinic Acid is a useful reagent for the modulation of protein-?protein interactions to learn about the mechanisms in amyloid assembly.
Uses
2,6-Dichloro-5-fluoropyridine-3-carboxylic acid (2,6-Dichloro-5-fluoro-3-pyridinecarboxylic acid) may be used in the preparation of self assembled monolayer (SAMs) compounds.
General Description
2,6-Dichloro-5-fluoropyridine-3-carboxylic acid is a halogenated heterocyclic compound. Its density has been reported to be 1.6207g/cm3 at 25°C.
Synthesis
82671-03-2
82671-06-5
The general procedure for the synthesis of 2,6-dichloro-5-fluoropyridine-3-carboxylic acid from ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate is as follows: Example 1: 1. ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate (20 g, 84 mmol) was dissolved in a mixture of 40 mL of trifluoroacetic acid and 40 mL of 7.5N hydrochloric acid. 2. The mixture was heated to reflux and kept reacting for 24 hours. 3. Upon completion of the reaction, the solution was cooled and the trifluoroacetic acid was removed by evaporation under reduced pressure. 4. After cooling to room temperature, 100 mL of water was added, at which point a white precipitate formed in the solution. 5. The precipitate was collected by filtration, washed with hexane, and dried to give 12.91 g (73.2% yield) of 2,6-dichloro-5-fluoropyridine-3-carboxylic acid, with a melting point of 153-154 °C. The reaction was completed with the addition of 100 mL of water.
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 11, p. 2364 - 2369
[2] Patent: EP302372, 1989, A1
[3] Patent: US2014/73631, 2014, A1. Location in patent: Paragraph 0128; 0129
2,6-Dichloro-5-fluoronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dichloro-5-fluoronicotinic acid manufacturers
- Product
- 2,6-Dichloro-5-fluoronicotinic acid 82671-06-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- As your request
- Release date
- 2025-10-30
- Product
- 2,6-Dichloro-5-fluoronicotinic acid 82671-06-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 2,6-Dichloro-5-fluoronicotinic acid 82671-06-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-14