ChemicalBook > CAS DataBase List > 2,6-Dichloro-5-fluoronicotinic acid

2,6-Dichloro-5-fluoronicotinic acid

Product Name
2,6-Dichloro-5-fluoronicotinic acid
CAS No.
82671-06-5
Chemical Name
2,6-Dichloro-5-fluoronicotinic acid
Synonyms
2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXYLIC ACID;2,6-Dichloro-5-Fluoronicotinic;2,6-DICHLORO-5-FLUORO-3-PYRIDINECARBOXYLIC ACID;RARECHEM AL BO 0975;TIMTEC-BB SBB003450;Fluorine chlorine niacin;Tosufloxacin tosilate Impurity 4;2,6-Dichloro-5-fluoronicotic acid;2,6-Dichloro-5-Fluoronicotinic API;2,6-Dichloro-5-fluoronictonic acid
CBNumber
CB3189052
Molecular Formula
C6H2Cl2FNO2
Formula Weight
209.99
MOL File
82671-06-5.mol
More
Less

2,6-Dichloro-5-fluoronicotinic acid Property

Melting point:
152-155 °C (lit.)
Boiling point:
247°C (rough estimate)
Density 
1.6207 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
1.38±0.32(Predicted)
color 
White to Yellow to Orange
BRN 
4311035
InChI
InChI=1S/C6H2Cl2FNO2/c7-4-2(6(11)12)1-3(9)5(8)10-4/h1H,(H,11,12)
InChIKey
LTDGKGCHRNNCAC-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=C(F)C=C1C(O)=O
CAS DataBase Reference
82671-06-5(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
1
HazardClass 
IRRITANT
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
D2610
Product name
2,6-Dichloro-5-fluoronicotinic Acid
Purity
>97.0%(T)
Packaging
5g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
D2610
Product name
2,6-Dichloro-5-fluoronicotinic Acid
Purity
>97.0%(T)
Packaging
25g
Price
$53
Updated
2025/07/31
TRC
Product number
D437088
Product name
2,6-Dichloro-5-fluoronicotinic Acid
Packaging
1g
Price
$55
Updated
2021/12/16
TRC
Product number
D437088
Product name
2,6-Dichloro-5-fluoronicotinic Acid
Packaging
2.5g
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
011229
Product name
2,6-Dichloro-5-fluoronicotinic acid
Purity
96%
Packaging
5g
Price
$10
Updated
2021/12/16
More
Less

2,6-Dichloro-5-fluoronicotinic acid Chemical Properties,Usage,Production

Chemical Properties

light yellow to beige fine crystalline powder

Uses

2,6-Dichloro-5-fluoronicotinic Acid is a useful reagent for the modulation of protein-?protein interactions to learn about the mechanisms in amyloid assembly.

Uses

2,6-Dichloro-5-fluoropyridine-3-carboxylic acid (2,6-Dichloro-5-fluoro-3-pyridinecarboxylic acid) may be used in the preparation of self assembled monolayer (SAMs) compounds.

General Description

2,6-Dichloro-5-fluoropyridine-3-carboxylic acid is a halogenated heterocyclic compound. Its density has been reported to be 1.6207g/cm3 at 25°C.

Synthesis

82671-03-2

82671-06-5

The general procedure for the synthesis of 2,6-dichloro-5-fluoropyridine-3-carboxylic acid from ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate is as follows: Example 1: 1. ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate (20 g, 84 mmol) was dissolved in a mixture of 40 mL of trifluoroacetic acid and 40 mL of 7.5N hydrochloric acid. 2. The mixture was heated to reflux and kept reacting for 24 hours. 3. Upon completion of the reaction, the solution was cooled and the trifluoroacetic acid was removed by evaporation under reduced pressure. 4. After cooling to room temperature, 100 mL of water was added, at which point a white precipitate formed in the solution. 5. The precipitate was collected by filtration, washed with hexane, and dried to give 12.91 g (73.2% yield) of 2,6-dichloro-5-fluoropyridine-3-carboxylic acid, with a melting point of 153-154 °C. The reaction was completed with the addition of 100 mL of water.

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 11, p. 2364 - 2369
[2] Patent: EP302372, 1989, A1
[3] Patent: US2014/73631, 2014, A1. Location in patent: Paragraph 0128; 0129

2,6-Dichloro-5-fluoronicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,6-Dichloro-5-fluoronicotinic acid Suppliers

Americas 1 Belgium 2 China 293 Europe 3 Germany 4 India 5 Italy 1 Japan 1 Slovakia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 13 United States 28 Global 356
Taizhou zhenhe chemical co. LTD
Tel
576-88887792 13386577269
Fax
0576-88931773
Email
sales@zhenhechemical.com
Country
China
ProdList
115
Advantage
58
Qingdao Dexin Chemical Co., Ltd
Tel
18353358123
Email
839877395@qq.com
Country
China
ProdList
255
Advantage
58
Jinan Dexinjia Bio&Tech Co., Ltd
Tel
0531-82371986 15269101859
Fax
0531-82375893
Email
3276840968@qq.com
Country
China
ProdList
1604
Advantage
58
Wuhan EnTai Technology Development Co,.Ltd
Tel
86-27-82330560
Fax
86-27-82330547
Email
2536851935@qq.com
Country
China
ProdList
347
Advantage
69
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Changzhou Huanling Chemical Co., Ltd.
Tel
0519-89803565 13776850645
Fax
0519-89803575
Email
info4@huanlingchem.com
Country
China
ProdList
891
Advantage
68
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Chembon Pharmaceutical Co., Ltd.
Tel
028-84252981
Fax
+86-28-84252965
Email
sales@chembon.com.cn
Country
China
ProdList
850
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
Email
1791901229@qq.com
Country
China
ProdList
6945
Advantage
52
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
Shanghai Hope Chem Co., Ltd.，
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
474
Advantage
55
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Shanghai Junye chemical Co., Ltd
Tel
021-021-50318666 18516602538
Fax
+86-21-61924293
Email
shlip@163.com
Country
China
ProdList
58
Advantage
58
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Candia Thamtech Company Limited
Tel
0371-86615086 18203638366 0371-86159066 13526786601
Fax
0371-86159066
Country
China
ProdList
2015
Advantage
60
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Anichem Inc.
Tel
0512-69369885
Fax
0512-69369880
Email
sales@anichem.com.cn
Country
China
ProdList
495
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-0371-13526885213 15637198702
Fax
0371-63709726
Email
hsyykjchem@163.com
Country
China
ProdList
3853
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
More
Less

View Lastest Price from 2,6-Dichloro-5-fluoronicotinic acid manufacturers

Changzhou waston chemical technology Co.,Ltd
Product
2,6-Dichloro-5-fluoronicotinic acid 82671-06-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
As your request
Release date
2025-10-30
Henan Aochuang Chemical Co.,Ltd.
Product
2,6-Dichloro-5-fluoronicotinic acid 82671-06-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Hebei Zhanyao Biotechnology Co. Ltd
Product
2,6-Dichloro-5-fluoronicotinic acid 82671-06-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-14

82671-06-5, 2,6-Dichloro-5-fluoronicotinic acidRelated Search:

Thionyl chloride Sodium dichloroisocyanurate Dichloroethane 2-Chloro-5-fluoronicotinic acid Dichlorofluoroethane 5-Fluoronicotinic acid QUINOLINE-3-CARBOXYLIC ACID Nicotinic acid Nicotine 2,6-Dichloro-5-fluoronicotinic acid ethyl ester Dichlorodifluoromethane 2,6-Dichloro-5-fluoronicotinic acid 2,6-Dichloro-5-fluoro-4-methylpyridine-3-carboxylic acid METHYL 2,6-DICHLORO-5-FLUORONICOTINATE Ethyl 2,6-dichloro-5-fluoronicotinate PHENYL 2,6-DICHLORO-5-FLUORONICOTINATE 2,6-DIMETHYLPHENYL 2,6-DICHLORO-5-FLUORONICOTINATE 3-METHOXYPHENYL 2,6-DICHLORO-5-FLUORONICOTINATE

  • 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid,97%
  • 2,6-Dichloro-5-fluoronicotic acid
  • 3-Pyridinecarboxylic acid, 2,6-dichloro-5-fluoro-
  • 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, 97% 5GR
  • 2,6-Dichloro-5-Fluoronicotinic API
  • 2,6-Dichloro-5-fouoro-3-pyridinecarboxylicacid
  • 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, 3-Carboxy-2,6-dichloro-5-fluoropyridine
  • Fluorine chlorine niacin
  • 2,6-Dichloro-5-fluoronicotinicacid,96%
  • 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid 97%
  • RARECHEM AL BO 0975
  • TIMTEC-BB SBB003450
  • 2,6-DICHLORO-5-FLUORONICOTINIC ACID
  • 2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXYLIC ACID
  • 2,6-DICHLORO-5-FLUORO-3-PYRIDINECARBOXYLIC ACID
  • 2,6-Dichloro-5-Fluoro-3-Pyridinecarboxlic Acid
  • 2,6-Dichloro-5-fluoronictonic acid
  • 2,6-Dichloro-5-Fluoronicotinic
  • 2,6-Dichloro-5-fluoronicotinic acid 97%
  • 2,6-Dichloro-5-fluoronicotinicacid97%
  • 2,6-Dichlor-5-fluor-3-pyridincarbonsure
  • 2,6-Dichloro-5-fuoronicotinic acid
  • 2,6-Dichloro-5-fluoronicotinicAcid&gt
  • 2,6-Dichloro-5-fluoronicotinic acid ISO 9001：2015 REACH
  • 2,6-Dichloro-5-fluoropyridin-3-carboxylic acid
  • Tosufloxacin tosilate Impurity 4
  • 82671-06-5
  • C6H2NO2Cl2F
  • Building Blocks
  • Chloropyridines
  • Fluoropyridines
  • Halopyridines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyridines
  • Pyridines, Pyrimidines, Purines and Pteredines
  • pharmacetical
  • Carboxylic Acids
  • Fluorine series
  • Pyridines
  • Chloropyridines
  • Fluoropyridines
  • Halopyridines
  • Carboxylic Acids
  • carboxylic acid| alkyl chloride| alkyl Fluorine