4,6-DICHLORO-PYRIDIN-3-YLAMINE
- Product Name
- 4,6-DICHLORO-PYRIDIN-3-YLAMINE
- CAS No.
- 7321-93-9
- Chemical Name
- 4,6-DICHLORO-PYRIDIN-3-YLAMINE
- Synonyms
- 4,6-DICHLOROPYRIDIN-3-AMINE;4,6-Dichloro-3-pyridinamine;2,4-Dichloro-5-aMinopyridine;5-AMINO-2,4-DICHLOROPYRIDINE;3-Pyridinamine, 4,6-dichloro-;4,6-DICHLORO-PYRIDIN-3-YLAMINE;5-Amino-2,4-dichloropyridine 97+%;Pyridine,5-amino-2,4-dichloro- (7CI,8CI);4,6-DICHLORO-PYRIDIN-3-YLAMINE ISO 9001：2015 REACH
- CBNumber
- CB7222007
- Molecular Formula
- C5H4Cl2N2
- Formula Weight
- 163
- MOL File
- 7321-93-9.mol
4,6-DICHLORO-PYRIDIN-3-YLAMINE Property
- Melting point:
- 80-81 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 290.8±35.0 °C(Predicted)
- Density
- 1.497±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Powder
- pka
- 0.72±0.10(Predicted)
- color
- Pale brown
- InChI
- InChI=1S/C5H4Cl2N2/c6-3-1-5(7)9-2-4(3)8/h1-2H,8H2
- InChIKey
- FBGVTWONYOCYGA-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC(Cl)=C1N
Safety
- RIDADR
- UN2811
- HazardClass
- 6.1
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A596935
- Product name
- 5-Amino-2,4-dichloropyridine
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- A596935
- Product name
- 5-Amino-2,4-dichloropyridine
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- A596935
- Product name
- 5-Amino-2,4-dichloropyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD51058
- Product name
- 4,6-Dichloro-pyridin-3-ylamine
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 116107
- Product name
- 4,6-Dichloropyridin-3-amine
- Purity
- >97%
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
4,6-DICHLORO-PYRIDIN-3-YLAMINE Chemical Properties,Usage,Production
Uses
4,6-Dichloropyridin-3-amine is an organic amine compound used in the synthesis of 2,4,5-Trichloropyridine and its derivatives. It is also used as a pharmaceutical intermediate component in the preparation of aromatic bridging cyclic amide derivatives for hepatitis B virus infection.
Synthesis
70593-57-6
7321-93-9
The general procedure for the synthesis of 2,4-dichloro-5-aminopyridine from 4,6-dichloropyridin-3-amide was as follows: sodium hydroxide (6.60 g, 165 mmol) was dissolved in water (31 mL) and cooled in an ice bath. Subsequently, bromine (2.08 mL, 40.6 mmol) was added dropwise and the resulting yellow solution was stirred for 15 minutes. A 1,4-dioxane (21 mL) solution of 4,6-dichloronicotinamide (7.27 g, 38.1 mmol) was slowly added dropwise to the above bromine solution over 30 minutes. The reaction mixture was allowed to gradually warm up to 25°C over 18 hours. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure and the remaining solution was diluted with brine and poured into ethyl acetate. The aqueous phase was separated and extracted twice with ethyl acetate. The organic layers were combined, dried with sodium sulfate, decanted and concentrated to give an orange colored oil. The oily substance was purified by passing through a 100 g silica gel fast column using 25% ethyl acetate-hexane as eluent to give 4,6-dichloropyridin-3-ylamine as a brown solid (4.54 g, 73% yield). Finally, 30% aqueous hydrogen peroxide solution (29 mL) was cooled in an ice bath.
References
[1] Patent: US2006/217417, 2006, A1. Location in patent: Page/Page column 13
4,6-DICHLORO-PYRIDIN-3-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-DICHLORO-PYRIDIN-3-YLAMINE manufacturers
- Product
- 4,6-DICHLORO-PYRIDIN-3-YLAMINE 7321-93-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
- Product
- 4,6-DICHLORO-PYRIDIN-3-YLAMINE 7321-93-9
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg, 10kg ,50kg
- Release date
- 2020-03-09