ChemicalBook > CAS DataBase List > 4,6-DICHLORO-PYRIDIN-3-YLAMINE

4,6-DICHLORO-PYRIDIN-3-YLAMINE

Product Name: 4,6-DICHLORO-PYRIDIN-3-YLAMINE
CAS No.: 7321-93-9
Chemical Name: 4,6-DICHLORO-PYRIDIN-3-YLAMINE
Synonyms: 4,6-DICHLOROPYRIDIN-3-AMINE;4,6-Dichloro-3-pyridinamine;2,4-Dichloro-5-aMinopyridine;5-AMINO-2,4-DICHLOROPYRIDINE;3-Pyridinamine, 4,6-dichloro-;4,6-DICHLORO-PYRIDIN-3-YLAMINE;5-Amino-2,4-dichloropyridine 97+%;Pyridine,5-amino-2,4-dichloro- (7CI,8CI);4,6-DICHLORO-PYRIDIN-3-YLAMINE ISO 9001：2015 REACH
CBNumber: CB7222007
Molecular Formula: C5H4Cl2N2
Formula Weight: 163
MOL File: 7321-93-9.mol

Less

4,6-DICHLORO-PYRIDIN-3-YLAMINE Property

Melting point:: 80-81 °C(Solv: ligroine (8032-32-4))
Boiling point:: 290.8±35.0 °C(Predicted)
Density: 1.497±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: Powder
pka: 0.72±0.10(Predicted)
color: Pale brown
InChI: InChI=1S/C5H4Cl2N2/c6-3-1-5(7)9-2-4(3)8/h1-2H,8H2
InChIKey: FBGVTWONYOCYGA-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=CC(Cl)=C1N

Less

Safety

RIDADR: UN2811
HazardClass: 6.1
HS Code: 2933399990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

TRC

Product number: A596935
Product name: 5-Amino-2,4-dichloropyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A596935
Product name: 5-Amino-2,4-dichloropyridine
Packaging: 500mg
Price: $95
Updated: 2021/12/16

TRC

Product number: A596935
Product name: 5-Amino-2,4-dichloropyridine
Packaging: 1g
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD51058
Product name: 4,6-Dichloro-pyridin-3-ylamine
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 116107
Product name: 4,6-Dichloropyridin-3-amine
Purity: >97%
Packaging: 1g
Price: $98
Updated: 2021/12/16

Less

4,6-DICHLORO-PYRIDIN-3-YLAMINE Chemical Properties,Usage,Production

Uses

4,6-Dichloropyridin-3-amine is an organic amine compound used in the synthesis of 2,4,5-Trichloropyridine and its derivatives. It is also used as a pharmaceutical intermediate component in the preparation of aromatic bridging cyclic amide derivatives for hepatitis B virus infection.

Synthesis

70593-57-6

7321-93-9

The general procedure for the synthesis of 2,4-dichloro-5-aminopyridine from 4,6-dichloropyridin-3-amide was as follows: sodium hydroxide (6.60 g, 165 mmol) was dissolved in water (31 mL) and cooled in an ice bath. Subsequently, bromine (2.08 mL, 40.6 mmol) was added dropwise and the resulting yellow solution was stirred for 15 minutes. A 1,4-dioxane (21 mL) solution of 4,6-dichloronicotinamide (7.27 g, 38.1 mmol) was slowly added dropwise to the above bromine solution over 30 minutes. The reaction mixture was allowed to gradually warm up to 25°C over 18 hours. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure and the remaining solution was diluted with brine and poured into ethyl acetate. The aqueous phase was separated and extracted twice with ethyl acetate. The organic layers were combined, dried with sodium sulfate, decanted and concentrated to give an orange colored oil. The oily substance was purified by passing through a 100 g silica gel fast column using 25% ethyl acetate-hexane as eluent to give 4,6-dichloropyridin-3-ylamine as a brown solid (4.54 g, 73% yield). Finally, 30% aqueous hydrogen peroxide solution (29 mL) was cooled in an ice bath.

References

[1] Patent: US2006/217417, 2006, A1. Location in patent: Page/Page column 13

4,6-DICHLORO-PYRIDIN-3-YLAMINE Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Diphenylphosphoryl azide Sodium sulfate Sodium chloride Toluene Trifluoroacetic acid tert-Butanol Triethylamine 4,6-Dichloronicotinic acid Ethyl acetate Sodium bicarbonate Dichloromethane PETROLEUM ETHER

Preparation Products

Less

4,6-DICHLORO-PYRIDIN-3-YLAMINE Suppliers

China 140 France 1 India 5 United Kingdom 2 United States 17 Global 165

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Nan Jing Dirise Chemcial Co.,LTD

Tel: 025-52161033 15312098939
Fax: 025-83254025
Email: sales@njdrschem.com
Country: China
ProdList: 578
Advantage: 64

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Record Tech (Shanghai) Co., LTD

Tel: 13761627472
Fax: 86-21-64965863
Email: 183009664@qq.com
Country: China
ProdList: 649
Advantage: 62

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Tongchuang Pharma(Suzhou). Co., Ltd.

Tel: 0512-63263366 18912765016
Fax: 0512-6326 3366
Email: tongtf110@sina.com
Country: China
ProdList: 993
Advantage: 62

Tianjin Jinyuda Chemical Co., Ltd.

Tel: 022-58013646 13011382049
Fax: 022-23854368
Email: sales@jinyudachem.com
Country: China
ProdList: 1930
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai potentpharm CO.,Ltd

Tel: 13524892556
Fax: (86) 21 51969655， QQ： 263541193
Email: sales-cn@potentpharm.com
Country: China
ProdList: 1011
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

GIHI CHEMICALS CO.,LTD

Tel: 0086-571-86217390
Fax: 0086-571-86217391
Email: Sales@gihichem.com
Country: China
ProdList: 860
Advantage: 58

Chimica Laboratories Co., Ltd

Tel: 0086-573-82585213
Fax: 0086-573-82585233
Email: bai@chimicalabs.com
Country: China
ProdList: 861
Advantage: 64

Shanghai Carlow Chemicals Co., Ltd.

Tel: 21-33526724 18930996265
Fax: 37023730
Email: info@carlowchem.com
Country: China
ProdList: 1922
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Hangzhou Milestone Pharmtech Co., Ltd.

Tel: 0571-82896630 18969958410
Email: sales_hz@milestonepharmtech.com
Country: China
ProdList: 4895
Advantage: 55

Bellen Chemistry Co., Ltd.

Tel: 010-60400365-8001 15910885229
Fax: 010-60400361
Email: service@bellenchem.com
Country: China
ProdList: 4514
Advantage: 60

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Shanghai Kahn Pharmaceutical Co., Ltd.

Tel: 021-34979681; 17701870669
Fax: 021-34979681
Email: 41513101@qq.com
Country: China
ProdList: 1785
Advantage: 55

Jiaxing Rich Biological Technology Co., Ltd.

Tel: 0573-11111111-1111 18969316891
Fax: -
Email: richmol@163.com
Country: China
ProdList: 449
Advantage: 50

Beatrice medicine technology Co., Ltd.

Tel: 15769589321 1548536191
Email: beatricechem@aliyun.com
Country: China
ProdList: 460
Advantage: 50

Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

Tel: 027-65388397 18164111589
Fax: 027-65388397
Email: 3321478047@qq.com
Country: China
ProdList: 2007
Advantage: 55

Shanghai Shinso-pharm Technology Co., Ltd.

Tel: 021-021-62165619 13917231399
Fax: 021-62165619
Email: sales@shinso-pharm.com.cn
Country: China
ProdList: 148
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9287
Advantage: 55

Shanghai Qing Cang Chemical Technology Co., Ltd.

Tel: 00000000000
Fax: -
Email: sales@qingcangchem.com
Country: China
ProdList: 509
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10410
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10109
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd.

Tel: 86-0573-85866609 13325730825
Fax: 0573-85866609
Email: 945717149@qq.com
Country: China
ProdList: 8595
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9721
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
Email: 248775804@qq.com
Country: China
ProdList: 4995
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Less

View Lastest Price from 4,6-DICHLORO-PYRIDIN-3-YLAMINE manufacturers

Dideu Industries Group Limited

Product: 4,6-DICHLORO-PYRIDIN-3-YLAMINE 7321-93-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: 4,6-DICHLORO-PYRIDIN-3-YLAMINE 7321-93-9
Price: US $6.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg, 10kg ,50kg
Release date: 2020-03-09

7321-93-9, 4,6-DICHLORO-PYRIDIN-3-YLAMINERelated Search:

2-Amino-2',5-dichlorobenzophenone 3,5-DICHLORO-PYRIDIN-4-YLAMINE Fluroxypyr 2,6-DICHLORO-PYRIDIN-4-YLAMINE 2-Amino-3,5-dichloropyridine 5,6-DICHLORO-PYRIDIN-3-YLAMINE 4,6-DICHLORO-2-METHYL-5-(1-ACETYL-2-IMIDAZOLIN-2-YL)-AMINOPYRIDINE 2,4-DICHLORO-5-NITROPYRIDINE 3,5-DICHLORO-4-AMINOPYRIDINE 3,5-DICHLORO-PYRIDIN-4-YLAMINE 4,6-DICHLORO-PYRIDIN-2-YLAMINE 3-Amino-2,6-dichloropyridine-4-carboxylic acid methyl ester 2,5-DICHLORO-PYRIDIN-3-YLAMINE 2,6-Dichloropyridin-3-amine 4,6-DICHLORO-PYRIDIN-3-YLAMINE 2,4,5,6-TETRACHLOROPYRIDIN-3-AMINE 4-Chloro-2,6-dimethyl-3-nitropyridine 1-(3-Amino-2,6-dichloropyridin-4-yl)ethanone ,98% 5,6-DICHLORO-3-AMINO PYRIDINE 5,6-DICHLORO-PYRIDIN-3-YLAMINE

5-AMINO-2,4-DICHLOROPYRIDINE

4,6-DICHLORO-PYRIDIN-3-YLAMINE

4,6-DICHLOROPYRIDIN-3-AMINE

3-Pyridinamine, 4,6-dichloro-

4,6-Dichloro-3-pyridinamine

Pyridine,5-amino-2,4-dichloro- (7CI,8CI)

2,4-Dichloro-5-aMinopyridine

5-Amino-2,4-dichloropyridine 97+%

4,6-DICHLORO-PYRIDIN-3-YLAMINE ISO 9001：2015 REACH

7321-93-9

Boronic Acid

Pyridine