ChemicalBook > CAS DataBase List > 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID

Product Name
2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
CAS No.
17969-20-9
Chemical Name
2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
Synonyms
mialex;8L-323S;ici54,450;Fenclozic;fenclozicacid;acidofenclozico;acidumfenclozicum;Acide p-chlorophenyl-2;2-(p-chlorophenyl)-4-thiazoleaceticaci;2-(4-chlorophenyl)-4-thiazoleaceticaci
CBNumber
CB6384960
Molecular Formula
C11H8ClNO2S
Formula Weight
253.7
MOL File
17969-20-9.mol
More
Less

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Property

Melting point:
150-152°C
Boiling point:
145°C (rough estimate)
Density 
1.2270 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.83±0.10(Predicted)
color 
Off-White to Pale Brown
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
HazardClass 
IRRITANT
Toxicity
LD50 in rats, mice (mg/kg): 850, 1000 orally; 250, 300 i.v. (Hepworth)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More
Less

N-Bromosuccinimide Price

TRC
Product number
F247530
Product name
FenclozicAcid
Packaging
500mg
Price
$275
Updated
2021/12/16
Matrix Scientific
Product number
045605
Product name
2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
Purity
>95%
Packaging
500mg
Price
$181
Updated
2021/12/16
Matrix Scientific
Product number
045605
Product name
2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
Purity
>95%
Packaging
1g
Price
$228
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC124498
Product name
[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
Packaging
100mg
Price
$58
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC124498
Product name
[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
Packaging
250mg
Price
$115
Updated
2021/12/16
More
Less

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Chemical Properties,Usage,Production

Originator

Fenclozic Acid,ZYF Pharm Chemical

Uses

Fenclozic Acid is a a potent antiinflammatory agent with analgesic and antipyretic properties and is a human hepatotoxic drug.

Manufacturing Process

3.7 parts of 2-(4-chlorophenyl)-4-cyanomethylthiazole and 35 parts of 6 N hydrochloric acid are heated under reflux for 2 hours. The solution is cooled by the addition of ice and made alkaline to pH 8 by the addition of 30% aqueous ammonia. The mixture is filtered to remove trace impurities, and an excess of 40% sodium hydroxide solution is then added to the filtrate to cause precipitation of a sodium salt, which is collected by filtration and crystallised from water. There is thus obtained sodium 2-(4-chlorophenyl)thiazol-4- ylacetate, M.P. 13°C (decomposition).
This sodium salt is dissolved in hot water, and the solution is brought to pH 4 by the addition of acetic acid, which causes the precipitation of 2-(4- chlorophenyl)thiazol-4-ylacetic acid. This is collected by filtration, washed with water, and dried in vacuo over phosphorus pentoxide. It has an M.P. 155- 156°C (from ethyl acetate).

Therapeutic Function

Antiinflammatory, Analgesic, Antipyretic

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Raise Chemical Technology Co.,Ltd
Tel
15026594951
Fax
0556-5030632
Email
rs@raise-chem.com
Country
China
ProdList
3588
Advantage
55
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7978
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Anmike Chemical Co. Ltd.
Tel
18019252918
Fax
021-31261685
Email
sale@amkchem.com
Country
China
ProdList
7301
Advantage
55
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15818
Advantage
58

17969-20-9, 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACIDRelated Search:


  • 2-(4-chlorophenyl)-4-thiazoleaceticaci
  • 2-(4-chlorophenyl)-4-thiazoleaceticacid
  • 2-(4-chlorophenyl)-thiazol-4-ylaceticacid
  • 2-(p-chlorophenyl)-4-thiazoleaceticaci
  • 2-(p-chlorophenyl)-4-thiazole-aceticacid
  • 2-(p-chlorophenyl)thiazol-4-ylaceticacid
  • acidep-chlorophenyl-2thiazole-acetique-4
  • acidofenclozico
  • acidumfenclozicum
  • fenclozicacid
  • ici54,450
  • mialex
  • 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
  • [2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
  • 2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethanoic acid
  • 2-[2-(4-chlorophenyl)-4-thiazolyl]acetic acid
  • 2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid
  • Fenclozic
  • 4-Thiazoleacetic acid, 2-(4-chlorophenyl)- (9CI)
  • 4-THIAZOLEACETIC ACID, 2-(p-CHLOROPHENYL)-
  • 8L-323S
  • Acide p-chlorophenyl-2
  • 4-Thiazoleacetic acid, 2-(4-chlorophenyl)-
  • [2(4Chlorophenyl)1,3thiazol4yl]acetic acid,[2 (4 Chlorophenyl) 1,3 thiazol 4 yl]acetic acid
  • 17969-20-9