ChemicalBook > CAS DataBase List > 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID

Product Name: 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
CAS No.: 17969-20-9
Chemical Name: 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
Synonyms: mialex;8L-323S;ici54,450;Fenclozic;fenclozicacid;acidofenclozico;acidumfenclozicum;Acide p-chlorophenyl-2;2-(p-chlorophenyl)-4-thiazoleaceticaci;2-(4-chlorophenyl)-4-thiazoleaceticaci
CBNumber: CB6384960
Molecular Formula: C11H8ClNO2S
Formula Weight: 253.7
MOL File: 17969-20-9.mol

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2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Property

Melting point:: 150-152°C
Boiling point:: 145°C (rough estimate)
Density: 1.2270 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.83±0.10(Predicted)
color: Off-White to Pale Brown

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Safety

Hazard Codes: Xn
Risk Statements: 22
HazardClass: IRRITANT
Toxicity: LD50 in rats, mice (mg/kg): 850, 1000 orally; 250, 300 i.v. (Hepworth)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed
Precautionary statements: P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: F247530
Product name: FenclozicAcid
Packaging: 500mg
Price: $275
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC124498
Product name: [2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
Packaging: 100mg
Price: $58
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC124498
Product name: [2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
Packaging: 250mg
Price: $115
Updated: 2021/12/16

Matrix Scientific

Product number: 045605
Product name: 2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
Purity: >95%
Packaging: 500mg
Price: $181
Updated: 2021/12/16

Matrix Scientific

Product number: 045605
Product name: 2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
Purity: >95%
Packaging: 1g
Price: $228
Updated: 2021/12/16

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2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Chemical Properties,Usage,Production

Originator

Fenclozic Acid,ZYF Pharm Chemical

Uses

Fenclozic Acid is a a potent antiinflammatory agent with analgesic and antipyretic properties and is a human hepatotoxic drug.

Manufacturing Process

3.7 parts of 2-(4-chlorophenyl)-4-cyanomethylthiazole and 35 parts of 6 N hydrochloric acid are heated under reflux for 2 hours. The solution is cooled by the addition of ice and made alkaline to pH 8 by the addition of 30% aqueous ammonia. The mixture is filtered to remove trace impurities, and an excess of 40% sodium hydroxide solution is then added to the filtrate to cause precipitation of a sodium salt, which is collected by filtration and crystallised from water. There is thus obtained sodium 2-(4-chlorophenyl)thiazol-4- ylacetate, M.P. 13°C (decomposition).
This sodium salt is dissolved in hot water, and the solution is brought to pH 4 by the addition of acetic acid, which causes the precipitation of 2-(4- chlorophenyl)thiazol-4-ylacetic acid. This is collected by filtration, washed with water, and dried in vacuo over phosphorus pentoxide. It has an M.P. 155- 156°C (from ethyl acetate).

Therapeutic Function

Antiinflammatory, Analgesic, Antipyretic

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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17969-20-9, 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACIDRelated Search:

[2-(3-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID 2-[4-(3-chlorophenyl)-1,3-thiazol-2-yl]acetic acid 2-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]acetic acid [2-(2-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID 2-[2-(4-CHLOROPHENYL)-5-METHYL-1,3-THIAZOL-4-YL]ACETIC ACID 2-(2-METHYL-1,3-THIAZOL-4-YL)ETHANOL 97+% 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID ISOPROPYL 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETATE (2-METHYL-THIAZOL-4-YL)-ACETIC ACID (2-PHENYL-THIAZOL-4-YL)-ACETIC ACID

2-(4-chlorophenyl)-4-thiazoleaceticaci

2-(4-chlorophenyl)-4-thiazoleaceticacid

2-(4-chlorophenyl)-thiazol-4-ylaceticacid

2-(p-chlorophenyl)-4-thiazoleaceticaci

2-(p-chlorophenyl)-4-thiazole-aceticacid

2-(p-chlorophenyl)thiazol-4-ylaceticacid

acidep-chlorophenyl-2thiazole-acetique-4

acidofenclozico

acidumfenclozicum

fenclozicacid

ici54,450

mialex

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID

[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID

2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethanoic acid

2-[2-(4-chlorophenyl)-4-thiazolyl]acetic acid

2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid

Fenclozic

4-Thiazoleacetic acid, 2-(4-chlorophenyl)- (9CI)

4-THIAZOLEACETIC ACID, 2-(p-CHLOROPHENYL)-

8L-323S

Acide p-chlorophenyl-2

4-Thiazoleacetic acid, 2-(4-chlorophenyl)-

[2(4Chlorophenyl)1,3thiazol4yl]acetic acid,[2 (4 Chlorophenyl) 1,3 thiazol 4 yl]acetic acid

[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid, 10 mM in DMSO

17969-20-9