Cefotiam hydrochloride

Product Name: Cefotiam hydrochloride
CAS No.: 66309-69-1
Chemical Name: Cefotiam hydrochloride
Synonyms: CEFOTIAM 2HCL;Spizef;Ceftiam;Halospor;Sporidyn;Pansporin;Cefapicol;Pansporine;Kemisporin;Sepidnarin
CBNumber: CB6386641
Molecular Formula: C18H23N9O4S3.HCl
Formula Weight: 562.08
MOL File: 66309-69-1.mol

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Cefotiam hydrochloride Property

Melting point:: >93°C (dec.)
Boiling point:: 94℃
RTECS: XI0367000
Flash point:: >110°(230°F)
storage temp.: Inert atmosphere,2-8°C
solubility: H2O: ≥22M
form: powder
color: white to tan
Water Solubility: Soluble in water
Stability:: Hygroscopic
InChIKey: BWRRTAXZCKVRON-DGPOFWGLSA-N
CAS DataBase Reference: 66309-69-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 2941906000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0056
Product name: Cefotiam dihydrochloride hydrate
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $34.4
Updated: 2024/03/01

Alfa Aesar

Product number: J66529
Product name: Cefotiam dihydrochloride
Packaging: 100mg
Price: $403
Updated: 2024/03/01

Alfa Aesar

Product number: J66529
Product name: Cefotiam dihydrochloride
Packaging: 50mg
Price: $262
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML0056
Product name: Cefotiam dihydrochloride hydrate
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $268
Updated: 2024/03/01

TRC

Product number: C243005
Product name: Cefotiam dihydrochloride
Packaging: 500mg
Price: $520
Updated: 2021/12/16

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Cefotiam hydrochloride Chemical Properties,Usage,Production

Description

Cefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.

Uses

Cefotiam hydrochloride (SCE-963 hydrochloride) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Definition

ChEBI: Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.

brand name

Ceradon (Takeda).

Pharmacokinetics

Cefotiam Hydrochloride is the hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Cefotiam hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Cefotiam hydrochloride Suppliers

Bangladesh 1 Belgium 1 Canada 3 China 218 Europe 1 France 1 Germany 5 India 10 Japan 2 South Korea 8 The Netherlands 1 United Kingdom 9 United States 26 Global 286

Carbosynth

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KEMPROTEC Limited

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Biosynth Carbosynth

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Whyte Chemicals

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Leancare Ltd.

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MOLEKULA Ltd.

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CARBONE SCIENTIFIC CO.,LTD

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ETA SCIENTIFIC Co.,Ltd

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UK GREEN SCIENTIFIC CO.,LIMITED

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View Lastest Price from Cefotiam hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cefotiam hydrochloride 66309-69-1
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 81%min
Supply Ability: 500kg
Release date: 2021-08-17

Hebei Henghe Import and Export Trading Co. LTD

Product: cefotiam hydrochloride 66309-69-1
Price: US $220.00/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 10
Release date: 2020-12-09

Hebei Henghe Import and Export Trading Co. LTD

Product: cefotiam hydrochloride 66309-69-1
Price: US $250.00/IU
Min. Order: 500KG
Purity: 99%
Supply Ability: 5
Release date: 2020-11-24

66309-69-1, Cefotiam hydrochlorideRelated Search:

Metoclopramide hydrochloride Cefazedone sodium salt Cefonicid sodium Cemandil sodium salt Cefotaxime sodium Ceftezole sodium Cefcapene pivoxil hydrochloride Bromhexine hydrochloride Ceftiofur hydrochloride Oxytetracycline hydrochloride Cefozopran hydrochloride Cefetamet pivoxil hydrochloride Cefmenoxime hydrochloride Nitrocefin Ceftazidime 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol 2-Aminothiazole-4-acetic acid Oxygen

cefotiam hydrochloride

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)-

Abbott 48999

Halospor

Pansporin

Pansporine

Spizef

Sporidyn

Cefotiam Hydrochloride (350 mg)

(6R,7R)-7-[2-(2-aMino-1,3-thiazol-4-yl)acetaMido]-3-[({1-[2-(diMethylaMino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6r-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride

Cefapicol

Kemisporin

Sepidnarin

(6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride

(6R,7R)-7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[[1-(2-dimethylaminoethyl)tetrazol-5-yl]thio]methyl]-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride

(6R,7R)-7-[2-(2-azanyl-1,3-thiazol-4-yl)ethanoylamino]-3-[[1-(2-dimethylaminoethyl)-1,2,3,4-tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride

Cefotiam Hydrochloride (325 mg)

cefotiamdihydrochloride

dihydrochloride,(6r-trans)--oxo

CEFOTIAM 2HCL

(6R,7R)-7-[[2-(2-AMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrochloride

20MG/100MG/KG

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-(2-aMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-,hydrochloride (1:2), (6R,7R)-

Ceftiam

(6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate

Cefotiam dihydrochloride hydrate

cefotian Hydrochloride

Cefotiam DiHCl

7-[[2-(2-amino-4-thiazolyl)-1-oxoethyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-5-tetrazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride

Cefotiam Dihydrochloride(Crude)

SCE-963 hydrochloride

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride

Cefotiam hydrochloride USP/EP/BP

(6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid

Cefotiam hydrochloride Impurities

Cefotiam Hydrochloride (1098005)

Cefotiame hydrochloride

66309-69-1

6309-69-1

66309-69-01

C18H23N9O4S3

C18H23N9O4S3HCl

C18H23N9O4S32HCl

C18H24ClN9O4S3

C18H25Cl2N9O4S3

59855

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Intermediates & Fine Chemicals

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