1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE
- Product Name
- 1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE
- CAS No.
- 110283-66-4
- Chemical Name
- 1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE
- Synonyms
- ci966;CI966HCl;CI 966 hydrochlorid;CI 966 HYDROCHLORIDE;CI-966 hydrochloride (CI966);3-pyridinecarboxylicacid,1,2,5,6-tetrahydro-1-(2-(bis(4-(trifluoromethyl)phen;1-[2-[BIS(4-(TRIFLUOROMETHYL)PHENYL)METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID;1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid hydrochloride;1-[2-bis[4-(Trifluormethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine3-carboxylic acid hydrochloride;1-(2-(Bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylicacidhydrochloride
- CBNumber
- CB6386777
- Molecular Formula
- C23H22ClF6NO3
- Formula Weight
- 509.87
- MOL File
- 110283-66-4.mol
1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE Property
- Melting point:
- 240-244 °C
- storage temp.
- Desiccate at RT
- solubility
- Soluble to 10 mM in ethanol and to 100 mM in DMSO
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1296
- Product name
- CI966hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $216
- Updated
- 2021/12/16
- Product number
- 1296
- Product name
- CI966hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $908
- Updated
- 2021/12/16
- Product number
- C475823
- Product name
- CI966Hydrochloride
- Packaging
- 2.5mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- 254973
- Product name
- CI 966 hydrochloride
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
- Product number
- B6677
- Product name
- CI966hydrochloride
- Packaging
- 10mg
- Price
- $314
- Updated
- 2021/12/16
1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
CI-966 Hydrochloride is highly selective for the cloned GABA transporter GAT-1. CI 966 Hydrochloride is a GABA transport inhibitor.
Biological Activity
Selective inhibitor of the GABA transporter GAT-1 (IC 50 values are 0.26 and 1.2 μ M at cloned human and rat GAT-1 respectively). Displays over 200-fold selectivity over GAT-2 and GAT-3. Centrally active upon systemic administration in vivo . Anticonvulsive and neuroprotective.
in vivo
CI-966 hydrochloride produces intermediate levels of Pentylenetetrazol (PTZ)-lever responding when administered to PTZ-trained rats[4].
CI-966 hydrochloride enhances gamma-aminobutyric acid action in CA1 pyramidal layer in situ. CI-966 hydrochloride is administered systemically by i.p. injection (5 mg/kg) in Sprague-Dawley rats under urethane anaesthesia. Twenty to thirty minutes after injection there is a highly variable, but overall significant, enhancement of the inhibition of hippocampal population spikes by GABA applied by microiontophoresis in the CA1 region[5].
CI-966 hydrochloride exhibits anticonvulsant properties in various animal models. Oral absorption of CI-966 hydrochloride in dogs given 1.39 mg/kg is rapid with a tmax of 0.7 hr.
In rats given 5 mg/kg oral, a mean tmax of 4.0 hr is observed. Following i.v. administration of the same respective doses, elimination t1/2 in dogs and rats averages 1.2 and 4.5 hr. Absolute oral bioavailability of CI-966 hydrochloride is 100% in both species[6].
| Animal Model: | Eight male Sprague-Dawley rats[4] |
| Dosage: | 0.3-30 mg/kg |
| Administration: | Injection IP in a volume of 1 mL/kg |
| Result: | Dose dependent decreases in rates of responding occurred following CI-966 administration. |
storage
Desiccate at RT