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(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE

Product Name
(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE
CAS No.
74588-78-6
Chemical Name
(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE
Synonyms
D-6413;CS-888;D-64131;D 64131; D64131;D-64131(sc-203908);(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE;Methanone,(5-methoxy-1H-indol-2-yl)phenyl-;tubulin-inhibitory,D64131,Inhibitor,D-64131,G2/M,antiproliferative,inhibit,Microtubule/Tubulin,phase,carcinoma,antimitotic,activity,cytotoxicity,D 64131,astrocytoma
CBNumber
CB6390031
Molecular Formula
C16H13NO2
Formula Weight
251.28
MOL File
74588-78-6.mol
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(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE Property

Melting point:
162 °C
Boiling point:
455.2±25.0 °C(Predicted)
Density 
1.231±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO
pka
14.81±0.30(Predicted)
form 
Crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J65995
Product name
D-64131
Packaging
10mg
Price
$154
Updated
2021/12/16
Cayman Chemical
Product number
22944
Product name
D-64131
Purity
≥98%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
22944
Product name
D-64131
Purity
≥98%
Packaging
10mg
Price
$175
Updated
2024/03/01
Cayman Chemical
Product number
22944
Product name
D-64131
Purity
≥98%
Packaging
25mg
Price
$385
Updated
2024/03/01
Cayman Chemical
Product number
22944
Product name
D-64131
Purity
≥98%
Packaging
50mg
Price
$577
Updated
2024/03/01
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(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE Chemical Properties,Usage,Production

Uses

Novel inhibitor of tubulin polymerization

Definition

ChEBI: (5-methoxy-1H-indol-2-yl)-phenylmethanone is a N-acylindole.

Biological Activity

Novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC 50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo .

References

1. beckers t, reissmann t, schmidt m et al. 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. cancer res. 2002 jun 1;62(11):3113-9.

(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE Suppliers

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View Lastest Price from (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE manufacturers

Career Henan Chemica Co
Product
(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE 74588-78-6
Price
US $1.00/g
Min. Order
1g
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-11-05

74588-78-6, (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONERelated Search:

2,7-DIMETHOXY-5,10-DIMETHYL-5,10-DIHYDRO-INDOLO[3,2-B]QUINOLIN-11-ONE (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE

  • D-64131
  • (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE
  • D-6413
  • D-64131(sc-203908)
  • CS-888
  • D 64131; D64131
  • Methanone,(5-methoxy-1H-indol-2-yl)phenyl-
  • tubulin-inhibitory,D64131,Inhibitor,D-64131,G2/M,antiproliferative,inhibit,Microtubule/Tubulin,phase,carcinoma,antimitotic,activity,cytotoxicity,D 64131,astrocytoma
  • 74588-78-6
  • Inhibitors
  • Caspases/Apoptosis