ChemicalBook > CAS DataBase List > 1-BROMO-2-CHLORO-3-NITROBENZENE

1-BROMO-2-CHLORO-3-NITROBENZENE

Product Name
1-BROMO-2-CHLORO-3-NITROBENZENE
CAS No.
3970-37-4
Chemical Name
1-BROMO-2-CHLORO-3-NITROBENZENE
Synonyms
oro-3-nitrobenzene;1-BROMO-2-CHLORO-3-NITROBENZENE;Benzene, 1-bromo-2-chloro-3-nitro-;1-BROMO-2-CHLORO-3-NITROBENZENE ISO 9001：2015 REACH
CBNumber
CB6391816
Molecular Formula
C6H3BrClNO2
Formula Weight
236.45
MOL File
3970-37-4.mol
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1-BROMO-2-CHLORO-3-NITROBENZENE Property

Melting point:
57-60°C
Boiling point:
290.4±20.0 °C(Predicted)
Density 
1.827±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Yellow
InChI
InChI=1S/C6H3BrClNO2/c7-4-2-1-3-5(6(4)8)9(10)11/h1-3H
InChIKey
JNIDAGAFFKAPRV-UHFFFAOYSA-N
SMILES
C1(Br)=CC=CC([N+]([O-])=O)=C1Cl
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Safety

HS Code 
2902900000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B682568
Product name
1-Bromo-2-chloro-3-nitrobenzene
Packaging
5g
Price
$225
Updated
2021/12/16
Matrix Scientific
Product number
074230
Product name
1-Bromo-2-chloro-3-nitrobenzene
Purity
95+%
Packaging
5g
Price
$205
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153849
Product name
1-Bromo-2-chloro-3-nitrobenzene
Packaging
5G
Price
$223
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153849
Product name
1-Bromo-2-chloro-3-nitrobenzene
Packaging
2g
Price
$112
Updated
2021/12/16
ChemScene
Product number
CS-W008709
Product name
1-Bromo-2-chloro-3-nitrobenzene
Purity
99.89%
Packaging
10g
Price
$175
Updated
2021/12/16
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1-BROMO-2-CHLORO-3-NITROBENZENE Chemical Properties,Usage,Production

Uses

1-Bromo-2-chloro-3-nitrobenzene is a reagent used in pharmaceutical synthesis. Used in the synthesis of benzodiazepinone bromodomain inhibitor CPI-?637 which may be applicable to cancer therapies.

Synthesis

3970-35-2

3970-37-4

General procedure for the synthesis of 1-bromo-2-chloro-3-nitrobenzene from 2-chloro-3-nitrobenzoic acid: 2-chloro-3-nitrobenzoic acid (15 g, 74.4 mmol) was dissolved in 350 mL of carbon tetrachloride under nitrogen protection and red mercuric oxide (24.3 g, 111.62 mmol) was added. The mixture was heated to 87°C under light conditions to reflux and bromine (5.75 mL, 111.6 mmol) was added slowly and dropwise. After the dropwise addition was completed, the reaction was continued at reflux for 3 h, followed by cooling to room temperature. The reaction mixture was quenched with saturated aqueous sodium bicarbonate solution, stirred for 10 min and filtered through a diatomaceous earth pad. The filter cake was further washed with dichloromethane. The organic layer was separated, washed sequentially with water and brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 11.55 g of 1-bromo-2-chloro-3-nitrobenzene in 67% yield. The product was detected by 400 MHz 1H NMR (CDCl3) with chemical shifts of δ 7.84 (d, 1H), 7.71 (d, 1H), 7.27 (dd, 1H); and mass spectra (M + 1) of 235, 237, 239.

References

[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 23, p. 4654 - 4666
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 20, p. 5392 - 5397
[3] Patent: WO2004/69832, 2004, A2. Location in patent: Page 126-127
[4] Patent: US2009/197932, 2009, A1. Location in patent: Page/Page column 5
[5] Patent: WO2008/12623, 2008, A1. Location in patent: Page/Page column 61

1-BROMO-2-CHLORO-3-NITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-BROMO-2-CHLORO-3-NITROBENZENE manufacturers

Henan Fengda Chemical Co., Ltd
Product
1-Bromo-2-chloro-3-nitrobenzene 3970-37-4
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Puyang Huicheng Electronic Materials Co., Ltd.
Product
1-bromo-2-chloro-3-nitrobenzene 3970-37-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.7%
Supply Ability
200tons
Release date
2023-02-15
Career Henan Chemical Co
Product
1-BROMO-2-CHLORO-3-NITROBENZENE 3970-37-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

3970-37-4, 1-BROMO-2-CHLORO-3-NITROBENZENERelated Search:

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  • 1-BROMO-2-CHLORO-3-NITROBENZENE
  • oro-3-nitrobenzene
  • Benzene, 1-bromo-2-chloro-3-nitro-
  • 1-BROMO-2-CHLORO-3-NITROBENZENE ISO 9001：2015 REACH
  • 3970-37-4