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(D-PEN2,PEN5)-ENKEPHALIN

Product Name
(D-PEN2,PEN5)-ENKEPHALIN
CAS No.
88373-72-2
Chemical Name
(D-PEN2,PEN5)-ENKEPHALIN
Synonyms
DPLPE;TYR-D-PEN-GLY-PHE-PEN;(D-PEN2,PEN5)-ENKEPHALIN;[D-PEN2,L-PEN5]-ENKEPHALIN;H-TYR-D-PEN-GLY-PHE-PEN-OH;L-Tyr-D-Pen-Glu-L-Phe-L-Pen-OH;H-Tyr-D-Pen-Gly-Phe-Pen-OH (Disulfide bond);Tyr-D-Pen-Gly-Phe-D-Pen (Disulfide bridge D-Pen2-D-Pen5);1,2-Dithia-5,8,11-triazacyclotetradecane,cyclic peptide deriv.;L-Valine, L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-, cyclic (2→5)-disulfide
CBNumber
CB6392222
Molecular Formula
C30H39N5O7S2
Formula Weight
645.79
MOL File
88373-72-2.mol
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(D-PEN2,PEN5)-ENKEPHALIN Property

storage temp. 
−20°C
form 
Solid
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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(D-PEN2,PEN5)-ENKEPHALIN Chemical Properties,Usage,Production

Uses

[DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin.html" class="link-product" target="_blank">[Leu5]-Enkephalin (HY-P0288)[1].

in vivo

[DPen2, Pen5] Enkephalin (0-3.32 μg/kg, IP) impairs acquisition of an automated jump-up avoidance response in rats and acquisition of a one-way active avoidance response in mice[1].

Animal Model:Male Sprague-Dawley rats (260-280 g)[1]
Dosage:0, 1.16, 11.6 μg/kg
Administration:IP, administered on day 2 prior to presentation of eight training trials, on subsequent one-way avoidance responding.
Result:Produced a significant impairment of avoidance performance at 1.16 ug/kg, while the 11.6 ug/kg dose was without significant effect.
Animal Model:Male Sprague-Dawley rats (260-280 g)[1]
Dosage:0, 0.332, 3.32 μg/kg
Administration:IP, administered on day 1 immediately after presentation of two escape-only trials, on subsequent day 2 one-way avoidance responding in the second experiment
Result:Produced a significant enhancement of avoidance performance at 0.332 ug/kg, while the 3.32 ug/kg dose was without significant effect.

IC 50

δ Opioid Receptor/DOR

References

[1] Martinez JL Jr, et al. D-Pen2-[D-Pen5]enkephalin impairs acquisition and enhances retention of a one-way active avoidance response in rats. Peptides. 1992 Sep-Oct;13(5):885-9. DOI:10.1016/0196-9781(92)90045-5

(D-PEN2,PEN5)-ENKEPHALIN Preparation Products And Raw materials

Raw materials

Preparation Products

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(D-PEN2,PEN5)-ENKEPHALIN Suppliers

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88373-72-2, (D-PEN2,PEN5)-ENKEPHALINRelated Search:

L-Penicillamine Glycyl-glycyl-L-valine N-Acetyl-L-cysteine S-tert-Butylmercapto-l-cysteine isopropyl methyl disulphide sec-Butyl disulfide ISOPROPYL DISULFIDE Di-tert-butyl disulfide N-ACETYL-DL-PENICILLAMINE (D-PEN2,P-CHLORO-PHE4,D-PEN5)-ENKEPHALIN [DES-TYR1, D-PEN2, PEN5]-ENKEPHALIN DI-TERT-AMYL DISULFIDE (D-PEN2,PEN5)-ENKEPHALIN H-PHE-VAL-OH N-Propionyl-L-cysteine isopropyl propyl disulphide DPDPE [TYROSYL-3,6-3H(N)]-

  • TYR-D-PEN-GLY-PHE-PEN
  • L-Tyr-D-Pen-Glu-L-Phe-L-Pen-OH
  • Tyr-D-Pen-Gly-Phe-D-Pen (Disulfide bridge D-Pen2-D-Pen5)
  • (D-PEN2,PEN5)-ENKEPHALIN
  • [D-PEN2,L-PEN5]-ENKEPHALIN
  • DPLPE
  • H-TYR-D-PEN-GLY-PHE-PEN-OH
  • H-Tyr-D-Pen-Gly-Phe-Pen-OH (Disulfide bond)
  • L-Valine, L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-, cyclic (2→5)-disulfide
  • 1,2-Dithia-5,8,11-triazacyclotetradecane,cyclic peptide deriv.
  • 88373-72-2
  • C30H39N5O7S2