ChemicalBook > CAS DataBase List > AC-VEID-CHO

AC-VEID-CHO

Product Name: AC-VEID-CHO
CAS No.: 319494-39-8
Chemical Name: AC-VEID-CHO
Synonyms: AC-VEID-CHO;AC-VEID-ALDEHYDE;CASPASE-6 INHIBITOR II;AC-VAL-GLU-ILE-ASP-CHO;VEID-CHO, CELL-PERMEABLE;AC-VAL-GLU-ILE-ASP-ALDEHYDE;N-Acetyl-Val-Glu-Ile-Asp-al;CASPASE 6 (MCH 2) INHIBITOR 1;CASPASE-6 INHIBITOR (ALDEHYDE);AC-VAL-GLU-ILE-ASP-H (ALDEHYDE)
CBNumber: CB6394958
Molecular Formula: C22H36N4O9
Formula Weight: 500.54
MOL File: Mol file

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AC-VEID-CHO Property

Boiling point:: 914.6±65.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: H₂O: 1 mg/mL
form: powder
pka: 4.20±0.10(Predicted)
color: white
Water Solubility: H2O: 1mg/mL

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27437
Product name: Ac-VEID-CHO (trifluoroacetate salt)
Packaging: 5mg
Price: $153
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FA111077
Product name: Ac-Val-Glu-Ile-Asp-aldehyde (pseudo acid)
Packaging: 5mg
Price: $263
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000162
Product name: CASPASE-6-(MCH-2)INHIBITOR 1
Purity: 95.00%
Packaging: 1MG
Price: $658.04
Updated: 2021/12/16

Chem-Impex

Product number: 32768
Product name: Ac-Val-Glu-Ile-Asp-aldehyde (pseudo acid)
Packaging: 25MG
Price: $880
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA111077
Product name: Ac-Val-Glu-Ile-Asp-aldehyde (pseudo acid)
Packaging: 25mg
Price: $913
Updated: 2021/12/16

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AC-VEID-CHO Chemical Properties,Usage,Production

Uses

AC-VEID-CHO is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO also inhibits VEIDase activity an IC50 value of 0.49 μM. AC-VEID-CHO can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease[1].

Biological Activity

Cell permeable: yes', 'Primary Target
caspase-6', 'Product does not compete with ATP.', 'Reversible: yes

IC 50

Caspase 3: 13.6 nM (IC₅₀); Caspase-6: 16.2 nM (IC₅₀); Caspase-7: 162.1 nM (IC₅₀)

References

[1] Robert Mintzer, et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One. 2012;7(1):e30376. DOI:10.1371/journal.pone.0030376

AC-VEID-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-VEID-CHO Suppliers

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319494-39-8, AC-VEID-CHORelated Search:

CASPASE-6 INHIBITOR (ALDEHYDE)

CASPASE-6 INHIBITOR II

CASPASE-6 INHIBITOR II, CELL-PERMEABLE

CASPASE 6 (MCH 2) INHIBITOR 1

ACETYL-L-VALYL-L-GLUTAMYL-L-ISOLEUCYL-L-ASPART-1-AL

AC-VAL-GLU-ILE-ASP-ALDEHYDE

AC-VAL-GLU-ILE-ASP-ALDEHYDE (PSEUDO ACID)

AC-VAL-GLU-ILE-ASP-CHO

AC-VAL-GLU-ILE-ASP-H (ALDEHYDE)

AC-VEID-ALDEHYDE

AC-VEID-CHO

N-ACETYL-VAL-GLU-ILE-ASPARTINAL

N-ACETYL-VAL-GLU-ILE-ASP-CHO (ALDEHYDE)

VEID-CHO, CELL-PERMEABLE

N-Acetyl-Val-Glu-Ile-Asp-al

Ac-VEID-CHO trifluoroacetate salt

L-Isoleucinamide, N-acetyl-L-valyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-

319494-39-8

Inhibitors

Apoptosis and Cell Cycle

Caspases

Caspase 6

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Caspases/Apoptosis

Pepetides

peptides