ChemicalBook > CAS DataBase List > AC-VEID-CHO

AC-VEID-CHO

Product Name
AC-VEID-CHO
CAS No.
319494-39-8
Chemical Name
AC-VEID-CHO
Synonyms
AC-VEID-CHO;AC-VEID-ALDEHYDE;CASPASE-6 INHIBITOR II;AC-VAL-GLU-ILE-ASP-CHO;VEID-CHO, CELL-PERMEABLE;AC-VAL-GLU-ILE-ASP-ALDEHYDE;N-Acetyl-Val-Glu-Ile-Asp-al;CASPASE 6 (MCH 2) INHIBITOR 1;CASPASE-6 INHIBITOR (ALDEHYDE);AC-VAL-GLU-ILE-ASP-H (ALDEHYDE)
CBNumber
CB6394958
Molecular Formula
C22H36N4O9
Formula Weight
500.54
MOL File
Mol file
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AC-VEID-CHO Property

Boiling point:
914.6±65.0 °C(Predicted)
Density 
1.238±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O: 1 mg/mL
form 
powder
pka
4.20±0.10(Predicted)
color 
white
Water Solubility 
H2O: 1mg/mL
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27437
Product name
Ac-VEID-CHO (trifluoroacetate salt)
Packaging
5mg
Price
$153
Updated
2024/03/01
Biosynth Carbosynth
Product number
FA111077
Product name
Ac-Val-Glu-Ile-Asp-aldehyde (pseudo acid)
Packaging
5mg
Price
$263
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000162
Product name
CASPASE-6-(MCH-2)INHIBITOR 1
Purity
95.00%
Packaging
1MG
Price
$658.04
Updated
2021/12/16
Chem-Impex
Product number
32768
Product name
Ac-Val-Glu-Ile-Asp-aldehyde (pseudo acid)
Packaging
25MG
Price
$880
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA111077
Product name
Ac-Val-Glu-Ile-Asp-aldehyde (pseudo acid)
Packaging
25mg
Price
$913
Updated
2021/12/16
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AC-VEID-CHO Chemical Properties,Usage,Production

Uses

AC-VEID-CHO is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO also inhibits VEIDase activity an IC50 value of 0.49 μM. AC-VEID-CHO can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease[1].

Biological Activity

Cell permeable: yes', 'Primary Target
caspase-6', 'Product does not compete with ATP.', 'Reversible: yes

IC 50

Caspase 3: 13.6 nM (IC50); Caspase-6: 16.2 nM (IC50); Caspase-7: 162.1 nM (IC50)

References

[1] Robert Mintzer, et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One. 2012;7(1):e30376. DOI:10.1371/journal.pone.0030376

AC-VEID-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-VEID-CHO Suppliers

China 48 Japan 2 Switzerland 2 United Kingdom 4 United States 15 Global 71
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
Peptide Institute, Inc.
Tel
--
Fax
--
Email
info@peptide.co.jp
Country
Japan
ProdList
992
Advantage
70

319494-39-8, AC-VEID-CHORelated Search:


  • CASPASE-6 INHIBITOR (ALDEHYDE)
  • CASPASE-6 INHIBITOR II
  • CASPASE-6 INHIBITOR II, CELL-PERMEABLE
  • CASPASE 6 (MCH 2) INHIBITOR 1
  • ACETYL-L-VALYL-L-GLUTAMYL-L-ISOLEUCYL-L-ASPART-1-AL
  • AC-VAL-GLU-ILE-ASP-ALDEHYDE
  • AC-VAL-GLU-ILE-ASP-ALDEHYDE (PSEUDO ACID)
  • AC-VAL-GLU-ILE-ASP-CHO
  • AC-VAL-GLU-ILE-ASP-H (ALDEHYDE)
  • AC-VEID-ALDEHYDE
  • AC-VEID-CHO
  • N-ACETYL-VAL-GLU-ILE-ASPARTINAL
  • N-ACETYL-VAL-GLU-ILE-ASP-CHO (ALDEHYDE)
  • VEID-CHO, CELL-PERMEABLE
  • N-Acetyl-Val-Glu-Ile-Asp-al
  • Ac-VEID-CHO trifluoroacetate salt
  • L-Isoleucinamide, N-acetyl-L-valyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-
  • 319494-39-8
  • Inhibitors
  • Apoptosis and Cell Cycle
  • Caspases
  • Caspase 6
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Caspases/Apoptosis
  • Pepetides
  • peptides