ChemicalBook > CAS DataBase List > TG003

TG003

Product Name
TG003
CAS No.
719277-26-6
Chemical Name
TG003
Synonyms
TG003;TG003（Z）;(1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;2-Propanone, 1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-, (1Z)-;(Z)-1-(3-ETHYL-5-METHOXY-2, 3-DIHYDROBENZOTHIAZOL-2-YLIDENE) PROPAN-2-ONE
CBNumber
CB6397580
Molecular Formula
C13H15NO2S
Formula Weight
249.33
MOL File
Mol file
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TG003 Property

Melting point:
132-132.5 °C
Boiling point:
386.0±42.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 33 mg/mL
form 
solid
pka
-1.54±0.20(Predicted)
color 
pale yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4336
Product name
TG003
Purity
≥98%(HPLC)
Packaging
10
Price
$212
Updated
2021/12/16
Tocris
Product number
4336
Product name
TG003
Purity
≥98%(HPLC)
Packaging
50
Price
$891
Updated
2021/12/16
TRC
Product number
T337700
Product name
TG003
Packaging
25mg
Price
$410
Updated
2021/12/16
Usbiological
Product number
256914
Product name
TG 003
Packaging
10mg
Price
$466
Updated
2021/12/16
ChemScene
Product number
CS-2036
Product name
TG003
Purity
99.54%
Packaging
10mg
Price
$180
Updated
2021/12/16
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TG003 Chemical Properties,Usage,Production

Description

TG003 (719277-26-6) is a potent, ATP-competitive inhibitor of Clk-family kinases (IC50‘s = 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3).1?Also inhibits DYRK1A/B (IC50‘s = 24 and 34 nM respectively).2 Suppresses serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles and Clk1/Sty-dependent alternative splicing in mammalian cells.1?TG003 affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo. Promotes skipping of exon 31 in the endogenous dystrophin gene.3 TG003 increases levels of Clk1/4 mature mRNAs by promoting splicing of the intron-retaining RNAs.4

Uses

TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases.

storage

Store at +4°C

References

1) Muraki et al. (2004), Manipulation of alternative splicing by a newly developed inhibitor of Clks; J. Biol. Chem., 279 24246 2) Foucourt et al. (2014), Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II; Molecules, 19 15411 3) Nishida et al. (2011), Chemical treatment enhances skipping of a mutated exon in the dystrophin gene; Nat. Commun., 2 308 4) Ninomiya et al. (2011), Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor; J. Cell Biol., 195 27

TG003 Preparation Products And Raw materials

Raw materials

Preparation Products

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TG003 Suppliers

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Nanjing Chemlin Chemical Co., Ltd
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View Lastest Price from TG003 manufacturers

Career Henan Chemical Co
Product
TG003 719277-26-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

719277-26-6, TG003Related Search:

THIOSTREPTON APICIDIN Retinoic acid IPTG

  • TG003
  • (Z)-1-(3-ETHYL-5-METHOXY-2, 3-DIHYDROBENZOTHIAZOL-2-YLIDENE) PROPAN-2-ONE
  • 2-Propanone, 1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-, (1Z)-
  • (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
  • TG003（Z）
  • 719277-26-6