ChemicalBook > CAS DataBase List > TG003

TG003

Product Name: TG003
CAS No.: 719277-26-6
Chemical Name: TG003
Synonyms: TG003;TG003（Z）;(1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;(1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzo[d]thiazolylidene)-2-propanone;2-Propanone, 1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-, (1Z)-;(Z)-1-(3-ETHYL-5-METHOXY-2, 3-DIHYDROBENZOTHIAZOL-2-YLIDENE) PROPAN-2-ONE
CBNumber: CB6397580
Molecular Formula: C13H15NO2S
Formula Weight: 249.33
MOL File: Mol file

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TG003 Property

Melting point:: 132-132.5 °C
Boiling point:: 386.0±42.0 °C(Predicted)
Density: 1.237±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 33 mg/mL
form: solid
pka: -1.54±0.20(Predicted)
color: pale yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4336
Product name: TG003
Purity: ≥98%(HPLC)
Packaging: 10
Price: $212
Updated: 2021/12/16

Tocris

Product number: 4336
Product name: TG003
Purity: ≥98%(HPLC)
Packaging: 50
Price: $891
Updated: 2021/12/16

TRC

Product number: T337700
Product name: TG003
Packaging: 25mg
Price: $410
Updated: 2021/12/16

Usbiological

Product number: 256914
Product name: TG 003
Packaging: 10mg
Price: $466
Updated: 2021/12/16

ChemScene

Product number: CS-2036
Product name: TG003
Purity: 99.54%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

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TG003 Chemical Properties,Usage,Production

Description

TG003 (719277-26-6) is a potent, ATP-competitive inhibitor of Clk-family kinases (IC50‘s = 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3).1?Also inhibits DYRK1A/B (IC50‘s = 24 and 34 nM respectively).2 Suppresses serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles and Clk1/Sty-dependent alternative splicing in mammalian cells.1?TG003 affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo. Promotes skipping of exon 31 in the endogenous dystrophin gene.3 TG003 increases levels of Clk1/4 mature mRNAs by promoting splicing of the intron-retaining RNAs.4

Uses

TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases.

in vivo

Intrathecal injection of either TG003 (1-100 pM) or IC261 (0.1-1 nM) dose-dependently decreases mechanical allodynia and thermal hyperalgesia induced by carrageenan or CFA^[3].

IC 50

CLK1: 20 nM (IC₅₀); CLK2: 200 nM (IC₅₀); CLK4: 15 nM (IC₅₀)

storage

Store at +4°C

References

[1] MICHIKO MURAKI. Manipulation of alternative splicing by a newly developed inhibitor of Clks.[J]. The Journal of Biological Chemistry, 2004: 24246-24254. DOI:10.1074/jbc.m314298200
[2] ALICIA FOUCOURT. Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II.[J]. Molecules, 2014, 19 10: 15411-15439. DOI:10.3390/molecules191015411
[3] ATSUSHI NISHIDA. Chemical treatment enhances skipping of a mutated exon in the dystrophin gene.[J]. Nature Communications, 2011: 308. DOI:10.1038/ncomms1306
[4] KENSUKE NINOMIYA Masatoshi H Naoyuki Kataoka. Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.[J]. Journal of Cell Biology, 2011, 195 1: 27-40. DOI:10.1083/jcb.201107093

TG003 Preparation Products And Raw materials

Raw materials

Preparation Products

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TG003 Suppliers

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View Lastest Price from TG003 manufacturers

Career Henan Chemical Co

Product: TG003 719277-26-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

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TG003

(Z)-1-(3-ETHYL-5-METHOXY-2, 3-DIHYDROBENZOTHIAZOL-2-YLIDENE) PROPAN-2-ONE

2-Propanone, 1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-, (1Z)-

(1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone

TG003（Z）

(1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzo[d]thiazolylidene)-2-propanone

719277-26-6