7-Hydroxyquinolinone

Product Name: 7-Hydroxyquinolinone
CAS No.: 70500-72-0
Chemical Name: 7-Hydroxyquinolinone
Synonyms: 7-Hydroxyquinolin-2(1H)-one;quinoline-2,7-diol;2,7-DIHYDROXYQUINOLINE;7-Hydroxy-;7-hydroxyquinolinone;7-Hydroxycarbostyril;7-hydroxy-2(1H)-Quino;7- hydroxy-2-quinolone;7-HYDROXY-2-QUINOLINONE;N1-(2,3-dichlorophenyl)-N2
CBNumber: CB6404930
Molecular Formula: C9H7NO2
Formula Weight: 161.16
MOL File: 70500-72-0.mol

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7-Hydroxyquinolinone Property

Melting point:: 187-192°C
Boiling point:: 426.8±45.0 °C(Predicted)
Density: 1.337±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 9.32±0.20(Predicted)
color: Off-White to Pale Yellow
Water Solubility: Water: Insoluble
InChI: InChI=1S/C9H7NO2/c11-7-3-1-6-2-4-9(12)10-8(6)5-7/h1-5,11H,(H,10,12)
InChIKey: DBSPUDKBNOZFMX-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(O)=C2)C=CC1=O
CAS DataBase Reference: 70500-72-0(CAS DataBase Reference)

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Safety

HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: H953255
Product name: 7-Hydroxyquinoline-(1H)-2-one
Packaging: 10g
Price: $365
Updated: 2021/12/16

Matrix Scientific

Product number: 072934
Product name: 2,7-Dihydroxyquinoline
Purity: 95+%
Packaging: 1g
Price: $12
Updated: 2021/12/16

AK Scientific

Product number: J91388
Product name: 7-Hydroxy-2-quinolinone
Packaging: 1g
Price: $15
Updated: 2021/12/16

Matrix Scientific

Product number: 072934
Product name: 2,7-Dihydroxyquinoline
Purity: 95+%
Packaging: 5g
Price: $31
Updated: 2021/12/16

Oakwood

Product number: 076721
Product name: 2,7-Dihydroxyquinoline
Purity: 97%
Packaging: 250mg
Price: $35
Updated: 2021/12/16

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7-Hydroxyquinolinone Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

7-Hydroxyquinolone is a substituted carbostyril derivative used as a pharmaceutical intermediate. It is an impurity of aripiprazole quinolinone.

Definition

ChEBI: 7-hydroxyquinolin-2(1H)-one is a monohydroxyquinoline and a quinolone.

Synthesis

127033-74-3

70500-72-0

General procedure for the synthesis of 7-hydroxyquinolin-2(1H)-one from N-(3-methoxyphenyl)cinnamamide: Aluminum trichloride (3.16 g, 23.69 mmol) was added batchwise to a suspension of chlorobenzene (30 mL) of compound 3 (1 g, 3.95 mmol) in an ice bath. The reaction mixture was gradually warmed up to 120 °C and kept at reflux for 3 hours. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure and the residue was purified by silica gel column chromatography to afford compound 4 in 54% yield.

References

[1] Synthesis, 1997, # 1, p. 87 - 90
[2] Tetrahedron Letters, 1999, vol. 40, # 24, p. 4505 - 4506
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5561 - 5578
[4] Patent: CN108101926, 2018, A. Location in patent: Paragraph 0033; 0034; 0035
[5] Patent: WO2008/24481, 2008, A2. Location in patent: Page/Page column 32

7-Hydroxyquinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Hydroxyquinolinone Suppliers

Canada 1 China 424 Germany 2 India 19 United Kingdom 6 United States 25 Global 477

Nanjing CoreTech Biomedical Co,.Ltd

Tel: 025-52880806 13770327895
Fax: 86-025-52880803
Email: API@core-tech.com.cn
Country: China
ProdList: 53
Advantage: 58

Chengdu Aofan Pharmtech Co.,Ltd

Tel: 15281070185; 13038283958
Email: 2865097598@qq.com
Country: China
ProdList: 111
Advantage: 55

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 023-13650506873 19923294409
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1604
Advantage: 58

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 603
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Email: wtx@bayeebio.com
Country: China
ProdList: 239
Advantage: 61

Gansu Haotian PharmaTech Co.,Ltd.

Tel: 17789447501
Email: zhuanxiajiang@haotianpharm.com
Country: China
ProdList: 202
Advantage: 58

Anqing CHICO Pharmaceutical Co., Ltd.

Tel: 13585175604 13057662806
Fax: +86-25-52261140
Email: sales@chicopharm.com
Country: China
ProdList: 494
Advantage: 65

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60189726 18812034280
Fax: 86-22-60979672
Email: 188120342808@163.com
Country: China
ProdList: 142
Advantage: 61

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

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View Lastest Price from 7-Hydroxyquinolinone manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 7-Hydroxyquinolinone 70500-72-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 7-Hydroxyquinolinone 70500-72-0
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Henan Aochuang Chemical Co.,Ltd.

Product: 7-Hydroxyquinolinone 70500-72-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-16

70500-72-0, 7-HydroxyquinolinoneRelated Search:

4'-Hydroxyacetophenone CHLOROPHOSPHONAZO III 2-Quinolinol Quinclorac Quinhydrone Ethoxyquin Isoquinoline 8-Hydroxyquinoline Brexpiprazole 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane BroMide 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE Brexpiprazole Impurity 20 Thianaphthene Brexpiprazole Impurity Brexpiprazole Impurity 2 Brexpiprazole sulfoxide impurity

2,7-DIHYDROXYQUINOLINE

7-HYDROXYQUINOLINE-(1H)-2-ONE

3,4-Dihydro-7-hydroxyquinoline-2(1H)-one

7-Hydroxyquinolin-2(1H)-one

3,4-DIHYDRO-7-HYDROXY-2(1H)-QUINOLINE

7-Hydroxycarbostyril

7-HYDROXY-2-QUINOLINONE

7-HYDROXY-1H-QUINOLIN-2-ONE

7-hydroxy-2-(1h)-quinolinone

7-HYDROXYQUINOLINE-2(1H)-ONE

7-hydroxyquinolinone

2(1H)-Quinolinone, 7-hydroxy-

quinoline-2,7-diol

7-Hydroxy-

7-hydroxy-1,2-dihydroquinolin-2-one

N1-(2,3-dichlorophenyl)-N2

4-Dihydro-7-hydroxycarbostyril

7- hydroxy-2-quinolone

7-hydroxy-2(1H)-Quino

7-Hydroxyquinolinone ISO 9001：2015 REACH

Aripiprazole impurities1777

Aripiprazole Quinolinone ImpurityQ: What is Aripiprazole Quinolinone Impurity Q: What is the CAS Number of Aripiprazole Quinolinone Impurity Q: What is the storage condition of Aripiprazole Quinolinone Impurity Q: What are the applications of Aripiprazole Quinolinone Impurity

Aripiprazole Quinolinone Impurity 7-Hydroxyquinoline-(1H)-2-one , 7-Hydroxy-2(1H)-quinolinone

Brexpiprazole Dimer Impurity 6

7-Hydroxycarbostyril, 10 mM in DMSO

7-Hydroxy-2(1<i>H</i>)-quinolinone

Aripiprazole Hydroxyquinolinone Analog

70500-72-0

142858-02-5

Aromatics Compounds

Quinoline

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Heterocycles