5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

Product Name: 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
CAS No.: 30389-33-4
Chemical Name: 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
Synonyms: 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one;5-Hydroxy-3,4-dihydrocarbostyryl;Carteolol EP Impurity B;5-HYDROXY-3;Carteolol int;Carteolol Impurity 2;Carteolol Intermediate;Aripiprazole impurity 7;Aripiprazole Impurity 14;Brexpiprazole Impurity 70
CBNumber: CB4259600
Molecular Formula: C9H9NO2
Formula Weight: 163.17
MOL File: 30389-33-4.mol

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5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Property

Melting point:: 225-227°C
Boiling point:: 381.2±42.0 °C(Predicted)
Density: 1.282±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.63±0.20(Predicted)
color: White to Off-White
InChI: InChI=1S/C9H9NO2/c11-8-3-1-2-7-6(8)4-5-9(12)10-7/h1-3,11H,4-5H2,(H,10,12)
InChIKey: UTTJAIFHRUAFED-UHFFFAOYSA-N
SMILES: N1C2=C(C(O)=CC=C2)CCC1=O
CAS DataBase Reference: 30389-33-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5669
Product name: 3,4-Dihydro-5-hydroxy-1H-quinolin-2-one
Packaging: 1G
Price: $56
Updated: 2024/03/01

TCI Chemical

Product number: D5669
Product name: 3,4-Dihydro-5-hydroxy-1H-quinolin-2-one
Packaging: 5G
Price: $278
Updated: 2024/03/01

TRC

Product number: H941410
Product name: 5-Hydroxy-3,4-dihydro-2(1H)-quinolinone
Packaging: 5g
Price: $425
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H20-1-17
Product name: 3,4-Dihydro-5-hydroxy-1H-quinolin-2-one
Packaging: 250mg
Price: $133
Updated: 2021/12/16

Ark Pharm

Product number: P000281586
Product name: 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
Purity: 97%
Packaging: 25g
Price: $390
Updated: 2021/12/16

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5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Chemical Properties,Usage,Production

Chemical Properties

Off-white Solid

Uses

Carteolol (C184450) metabolite.

Definition

ChEBI: 5-hydroxy-3,4-dihydro-2(1h)-quinolinone is a quinolone and a hydroxyquinoline.

Synthesis

To a 100 ml three-necked flask were added 3,4,7,8-tetrahydro-2,5 (1 H, 6Η) -quinoline dione (0.02 mol) and cyclohexane (25 ml). After stirring to dissolve in the ice bath for 10min, slowly add a dropwise N-bromosuccinimide (0.03mol) in cyclohexane (5ml), and reflux for 3h at the end of the dropwise addition. After completion of the reaction by TLC, cool down to room temperature. Water was added (the amount was 0.7 times the volume of the reactant), and the mixture was allowed to stand with stirring. The aqueous layer was extracted with ethyl acetate (1 × the volume of the aqueous layer 4 times), and the organic layers were combined. Anhydrous sulfuric acid Calcium was dried and filtered, the filtrate was evaporated to remove the solvent, and the residue was dried to give an off-white solid as a 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one (Yield 92.7percent).

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Suppliers

Americas 1 Canada 1 China 170 Europe 1 India 11 Japan 2 Slovakia 1 Ukraine 1 United Kingdom 4 United States 21 Global 213

Hangzhou Runyan Medical Technology Co., LTD

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Beijing Cooperate Pharmaceutical Co.,Ltd

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Jinan Hongwan Biotechnology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Energy Chemical

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Adamas Reagent, Ltd.

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Accela ChemBio Co.,Ltd.

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Nanjing Chemlin Chemical Co., Ltd

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View Lastest Price from 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one 30389-33-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99% HPLC
Supply Ability: 1000kg
Release date: 2022-11-08

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 30389-33-4
Price: US $65.00-650.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-20

Shaanxi Dideu Medichem Co. Ltd

Product: 5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 30389-33-4
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

30389-33-4, 5-Hydroxy-3,4-dihydroquinolin-2(1H)-oneRelated Search:

5-HYDROXY-2(1H)-QUINOLINONE 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane BroMide 7-Hydroxyquinolinone 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE Brexpiprazole Impurity 20 Thianaphthene Brexpiprazole Impurity Brexpiprazole Impurity 2 7-(4-chlorobutoxy)-1-{4-[(2-oxo-1,2-dihydroquinolin-7-yl)oxy]butyl}-1,2-dihydroquinolin-2-one Brexpiprazole sulfoxide impurity (E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE 1.1'-Binaphthyl-2.2'-diphemyl phosphine 8-hydroxy-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 4-BROMO-BENZO[B]THIOPHENE 7,7'-(butane-1,4-diylbis(oxy))bis(quinolin-2(1H)-one) 2(1H)-Quinolinone,7-(4-chlorobutoxy)- Brexpiprazole (3,4)-Dihydro-2(1H)-quinolinone 1,4-di(benzo[b]thiophen-4-yl)piperazine

3,4-DIHYDRO-5-HYDROXY-2(1H)-QUINOLINONE

5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE

5-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE

3,4-Dihydro-5-hydroxycarbostyril

5-HYDROXY-3,4-DIHYDRO-2-QUINOLINE

5-Hydroxy-2(1H)-3,4-dihydroquinolinone

3,4-Dihydro-5-hydroxy-1H-quinolin-2-one

5-Hydroxy-3,4-dihydrocarbostyril

3,4-Dihydro-5-hydroxyquinolin-2(1H)-one

5-Hydroxy-1,2,3,4-tetrahydroquinoline-2-one

5-hydroxy-1,2,3,4-tetrahydro-2-quinolinone

Carteolol int

Brexpiprazole Impurity 70

5-hydroxy-1,2,3,4-tetrahydroquinolin-2-one

5-Hydroxy-3,4-dihydrocarbostyryl

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

2(1H)-Quinolinone, 3,4-dihydro-5-hydroxy-

Carteolol HCl EP Impurity B

Carbostyril,3,4-dihydro-5-hydroxy- (8CI)

Aripiprazole Impurity 14

Carteolol Intermediate

5-Hydroxy-3,4-dihydroquinolin-2(1H)

Aripiprazole impurity 7

Carteolol Hydrochloride impurity B

Carteolol EP Impurity B

5-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one(For export only)

4-DIHYDRO-1H-QUINOLIN-2-ONE

5-HYDROXY-3

5-hydroxy-3,4-dihydro-1-h-quinoline

Aripiprazole impurities1768

Carteolol Impurity 2

Carteolol EP Impurity B（Aripiprazole Impurity 26）

5-Hydroxy-3,4-dihydro-2(1H)-quinolinone (5-HQ)

5-Hydroxy-3,4-dihydro-2(1h)- quinolinone, 98% (Custom work)

30389-33-4

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