ChemicalBook > CAS DataBase List > 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

Product Name
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
CAS No.
30389-33-4
Chemical Name
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
Synonyms
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one;5-Hydroxy-3,4-dihydrocarbostyryl;Carteolol EP Impurity B;5-HYDROXY-3;Carteolol int;Carteolol Impurity 2;Carteolol Intermediate;Carteolol HCl Impurity;Aripiprazole impurity 7;Aripiprazole Impurity 14
CBNumber
CB4259600
Molecular Formula
C9H9NO2
Formula Weight
163.17
MOL File
30389-33-4.mol
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5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Property

Melting point:
225-227°C
Boiling point:
381.2±42.0 °C(Predicted)
Density 
1.282±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.63±0.20(Predicted)
color 
White to Off-White
InChI
InChI=1S/C9H9NO2/c11-8-3-1-2-7-6(8)4-5-9(12)10-7/h1-3,11H,4-5H2,(H,10,12)
InChIKey
UTTJAIFHRUAFED-UHFFFAOYSA-N
SMILES
N1C2=C(C(O)=CC=C2)CCC1=O
CAS DataBase Reference
30389-33-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5669
Product name
3,4-Dihydro-5-hydroxy-1H-quinolin-2-one
Packaging
1G
Price
$67
Updated
2025/07/31
TCI Chemical
Product number
D5669
Product name
3,4-Dihydro-5-hydroxy-1H-quinolin-2-one
Packaging
5G
Price
$334
Updated
2025/07/31
TRC
Product number
H941410
Product name
5-Hydroxy-3,4-dihydro-2(1H)-quinolinone
Packaging
5g
Price
$425
Updated
2021/12/16
Ark Pharm
Product number
P000281586
Product name
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
Purity
97%
Packaging
25g
Price
$390
Updated
2021/12/16
Matrix Scientific
Product number
187820
Product name
3,4-Dihydro-5-hydroxyquinolin-2(1H)-one
Packaging
1g
Price
$395
Updated
2021/12/16
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5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Chemical Properties,Usage,Production

Chemical Properties

Off-white Solid

Uses

Carteolol (C184450) metabolite.

Definition

ChEBI: 5-hydroxy-3,4-dihydro-2(1h)-quinolinone is a quinolone and a hydroxyquinoline.

Synthesis

To a 100 ml three-necked flask were added 3,4,7,8-tetrahydro-2,5 (1 H, 6Η) -quinoline dione (0.02 mol) and cyclohexane (25 ml). After stirring to dissolve in the ice bath for 10min, slowly add a dropwise N-bromosuccinimide (0.03mol) in cyclohexane (5ml), and reflux for 3h at the end of the dropwise addition. After completion of the reaction by TLC, cool down to room temperature. Water was added (the amount was 0.7 times the volume of the reactant), and the mixture was allowed to stand with stirring. The aqueous layer was extracted with ethyl acetate (1 × the volume of the aqueous layer 4 times), and the organic layers were combined. Anhydrous sulfuric acid Calcium was dried and filtered, the filtrate was evaporated to remove the solvent, and the residue was dried to give an off-white solid as a 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one (Yield 92.7percent).

References

[1] Patent: CN107337639, 2017, A. Location in patent: Paragraph 0120; 0127; 0139; 0150; 0161; 0171; 0172; 0183

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one 30389-33-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99% HPLC
Supply Ability
1000kg
Release date
2022-11-08
Zibo Hangyu Biotechnology Development Co., Ltd
Product
5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 30389-33-4
Price
US $65.00-650.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-20
Shaanxi Dideu Medichem Co. Ltd
Product
5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 30389-33-4
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24

30389-33-4, 5-Hydroxy-3,4-dihydroquinolin-2(1H)-oneRelated Search:

5-HYDROXY-2(1H)-QUINOLINONE 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane BroMide 7-Hydroxyquinolinone 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE Brexpiprazole Impurity 20 Thianaphthene Brexpiprazole Impurity Brexpiprazole Impurity 2 7-(4-chlorobutoxy)-1-{4-[(2-oxo-1,2-dihydroquinolin-7-yl)oxy]butyl}-1,2-dihydroquinolin-2-one Brexpiprazole sulfoxide impurity (E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE 1.1'-Binaphthyl-2.2'-diphemyl phosphine 8-hydroxy-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 4-BROMO-BENZO[B]THIOPHENE 7,7'-(butane-1,4-diylbis(oxy))bis(quinolin-2(1H)-one) 2(1H)-Quinolinone,7-(4-chlorobutoxy)- Brexpiprazole (3,4)-Dihydro-2(1H)-quinolinone 1,4-di(benzo[b]thiophen-4-yl)piperazine

  • 3,4-DIHYDRO-5-HYDROXY-2(1H)-QUINOLINONE
  • 5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
  • 5-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE
  • 3,4-Dihydro-5-hydroxycarbostyril
  • 5-HYDROXY-3,4-DIHYDRO-2-QUINOLINE
  • 5-Hydroxy-2(1H)-3,4-dihydroquinolinone
  • 3,4-Dihydro-5-hydroxy-1H-quinolin-2-one
  • 5-Hydroxy-3,4-dihydrocarbostyril
  • 3,4-Dihydro-5-hydroxyquinolin-2(1H)-one
  • 5-Hydroxy-1,2,3,4-tetrahydroquinoline-2-one
  • 5-hydroxy-1,2,3,4-tetrahydro-2-quinolinone
  • Carteolol int
  • Brexpiprazole Impurity 70
  • 5-hydroxy-1,2,3,4-tetrahydroquinolin-2-one
  • 5-Hydroxy-3,4-dihydrocarbostyryl
  • 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
  • 2(1H)-Quinolinone, 3,4-dihydro-5-hydroxy-
  • Carteolol HCl EP Impurity B
  • Carbostyril,3,4-dihydro-5-hydroxy- (8CI)
  • Aripiprazole Impurity 14
  • Carteolol Intermediate
  • 5-Hydroxy-3,4-dihydroquinolin-2(1H)
  • Aripiprazole impurity 7
  • Carteolol Hydrochloride impurity B
  • Carteolol EP Impurity B
  • 5-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline
  • 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one(For export only)
  • 4-DIHYDRO-1H-QUINOLIN-2-ONE
  • 5-HYDROXY-3
  • 5-hydroxy-3,4-dihydro-1-h-quinoline
  • Aripiprazole impurities1768
  • Carteolol Impurity 2
  • Carteolol EP Impurity B（Aripiprazole Impurity 26）
  • 5-Hydroxy-3,4-dihydro-2(1H)-quinolinone (5-HQ)
  • 5-Hydroxy-3,4-dihydro-2(1h)- quinolinone, 98% (Custom work)
  • Carteolol HCl Impurity
  • 5-HYDROXY-3,4-DIHYDROQUINOLINE-2(1H)-ONE
  • 30389-33-4
  • pharmacetical
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
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