4-Bromobenzo[b]thiophene

Synthesis

Product Name: 4-Bromobenzo[b]thiophene
CAS No.: 5118-13-8
Chemical Name: 4-Bromobenzo[b]thiophene
Synonyms: 4-Bromobenzothiophene;4-BROMO-1-BENZOTHIOPHENE;4-bromo-thiophene;4-Bromothianaphthene;5-cyanobenzothiophene;Bromobenzo[b]thiophene;8-Quinolinol phosphate;4-BROMO-BENZO[B]THIOPHENE;Brexpiprazole intermdiate;Benzo[b]thiophene,4-broMo-
CBNumber: CB3813658
Molecular Formula: C8H5BrS
Formula Weight: 213.09
MOL File: 5118-13-8.mol

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4-Bromobenzo[b]thiophene Property

Boiling point:: 144 °C(Press: 20 Torr)
Density: 1.649±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: solid
color: White to off-white
InChI: InChI=1S/C8H5BrS/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5H
InChIKey: QPBSEYFVZDMBFW-UHFFFAOYSA-N
SMILES: C12=CC=CC(Br)=C1C=CS2

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B680503
Product name: 4-Bromo-benzo[b]thiophene
Packaging: 1g
Price: $75
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B1950
Product name: 4-Bromobenzo[b]thiophene
Purity: 95%
Packaging: 1g
Price: $8
Updated: 2021/12/16

AK Scientific

Product number: J97401
Product name: 4-Bromobenzo[b]thiophene
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 122176
Product name: 4-Bromobenzothiophene
Purity: 90+%
Packaging: 1g
Price: $10
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B1950
Product name: 4-Bromobenzo[b]thiophene
Purity: 95%
Packaging: 5g
Price: $20
Updated: 2021/12/16

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4-Bromobenzo[b]thiophene Chemical Properties,Usage,Production

Synthesis

The traditional synthesis method is to take 2-bromo-6-fluorobenzaldehyde as a raw material, cyclize the raw material with mercaptoacetic acid in a DMF solvent to obtain 4-chlorobenzo [b] thiophene-2-carboxylic acid, and then decarboxylate the product at a high temperature in a quinoline/copper powder system to obtain the 4-chlorobenzo [b] thiophene.

Uses

4-Bromobenzo[b]thiophene is an important intermediate in the drug ipiprazole for the treatment of schizophrenia.

References

[1] Patent: US2017/158680, 2017, A1. Location in patent: Paragraph 0361; 0368; 0369
[2] Tetrahedron Letters, 2004, vol. 45, # 52, p. 9645 - 9647
[3] Organic Process Research and Development, 2012, vol. 16, # 8, p. 1449 - 1454
[4] Patent: WO2007/92751, 2007, A2. Location in patent: Page/Page column 20-21
[5] Patent: EP1724277, 2006, A1. Location in patent: Page/Page column 28-29

4-Bromobenzo[b]thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromobenzo[b]thiophene Suppliers

Canada 1 China 272 India 9 United Kingdom 4 United States 19 Global 305

Chengdu Aofan Pharmtech Co.,Ltd

Tel: 15281070185; 13038283958
Email: 2865097598@qq.com
Country: China
ProdList: 111
Advantage: 55

Nanjing CoreTech Biomedical Co,.Ltd

Tel: 025-52880806 13770327895
Fax: 86-025-52880803
Email: API@core-tech.com.cn
Country: China
ProdList: 53
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Email: wtx@bayeebio.com
Country: China
ProdList: 239
Advantage: 61

Jinan Lide Pharmaceutical Technology Co., Ltd.

Tel: 0531-68654990 18560195202
Fax: 053168654990
Email: leadgxm@leadchem.net
Country: China
ProdList: 174
Advantage: 58

Sichuan Fanzhijian Biomedical Technology Co., Ltd

Tel: 15281070185
Email: 2865097598@qq.com
Country: China
ProdList: 898
Advantage: 58

Anqing CHICO Pharmaceutical Co., Ltd.

Tel: 13585175604 13057662806
Fax: +86-25-52261140
Email: sales@chicopharm.com
Country: China
ProdList: 494
Advantage: 65

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60189726 18812034280
Fax: 86-22-60979672
Email: 188120342808@163.com
Country: China
ProdList: 142
Advantage: 61

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

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View Lastest Price from 4-Bromobenzo[b]thiophene manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 4-Bromobenzo[b]thiophene 5118-13-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-06-17

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Bromobenzo[b]thiophene 5118-13-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-06

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Product: 4-Bromobenzo[b]thiophene 5118-13-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2-5 MTs
Release date: 2024-05-11

5118-13-8, 4-Bromobenzo[b]thiopheneRelated Search:

4-BROMO-BENZO[B]THIOPHENE

4-Bromobenzothiophene

4-BROMO-1-BENZOTHIOPHENE

4-Bromothianaphthene

5-cyanobenzothiophene

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Benzo[b]thiophene,4-broMo-

4-Bromo-1-benzothiophene, 4-Bromothianaphthene

4-BROMO-BENZO[B]THIOPHENE ISO 9001：2015 REACH

Brexpiprazole intermdiate

CAS5118-13-8 4-BROMO-BENZO[B]THIOPHENE

Bromobenzo[b]thiophene

Brexpiprazole Impurity 13 4-Bromo benzo[b]thiophene

8-Quinolinol phosphate

5118-13-8

Benzothiophene

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Organohalides