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IOXITALAMIC ACID

Product Name
IOXITALAMIC ACID
CAS No.
28179-44-4
Chemical Name
IOXITALAMIC ACID
Synonyms
AG-58107;Telebrix;Vasobrix;Ioxitalamic;IoxitalaMate;IOXITALAMIC ACID;iooxitalamic acid;Acidum Joxitalamicum;IOXITALAMIC ACID USP/EP/BP;3-Acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic acid
CBNumber
CB6406686
Molecular Formula
C12H11I3N2O5
Formula Weight
643.94
MOL File
28179-44-4.mol
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IOXITALAMIC ACID Property

Melting point:
253-255?C
Boiling point:
582.8±50.0 °C(Predicted)
Density 
2.519±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
Solid
pka
0.85±0.10(Predicted)
color 
Off-White to Pale Brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
I738100
Product name
IoxitalamicAcid
Packaging
1g
Price
$1065
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0069200
Product name
IOXITALAMIC ACID
Purity
95.00%
Packaging
10MG
Price
$2009.7
Updated
2021/12/16
Matrix Scientific
Product number
099667
Product name
3-Acetamido-5-((2-hydroxyethyl)carbamoyl)-2,4,6-triiodobenzoic acid
Purity
95+%
Packaging
1g
Price
$775
Updated
2021/12/16
Matrix Scientific
Product number
099667
Product name
3-Acetamido-5-((2-hydroxyethyl)carbamoyl)-2,4,6-triiodobenzoic acid
Purity
95+%
Packaging
250mg
Price
$327
Updated
2021/12/16
AK Scientific
Product number
Z3684
Product name
Ioxitalamicacid
Packaging
250mg
Price
$491
Updated
2021/12/16
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IOXITALAMIC ACID Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Oxilan,Cook Imaging Corporation

Uses

A substituted 2,4,6-triiodobenzoic acid, an excellent contrast media for ventriculography, radiculography, lumbar myelography and x-rays of the cardiovascular system.

Definition

ChEBI: An organoiodine compound that is 2,4,6-triiodobenzoic acid substituted by an acetylamino group at position 3 and a (2-hydroxyethyl)carbamoyl group at position 5. It is used as a contrast medium.

Manufacturing Process

3-Methoxycarboxyl-5-nitrobenzoic acid (25 g) was hydrogenated in methanol (500 ml) using palladium oxide on charcoal (2.5 g 10%) at atmospheric pressure. When the exothermic reaction was completed the catalyst was fluttered off. After cooling the solution at -20°C for 2.5 h, 12.7 g of 3-amino- 5-methoxycarbonylbenzoic acid was isolated. An additional 6.5 g of it was isolated by concentrating the mother liquor.
The 3-amino-5-methoxycarbonylbenzoic acid (12.0 g) was suspended in water (280 ml), dissolved by addition of concentrated hydrochloric acid (7.1 ml) and glacial acetic acid (28.5 ml). At 60°-70°C NaICl2 solution (73 ml, 58.7 g ICl/100 ml) was added dropwise while stirring in the course of about 3 h. The reaction mixture was heated at 80°-90°C for additional 3 h while stirring.
After cooling to room temperature the mother liquor was decanted and the residue dissolved as ammonium salt in water (80 ml). The ammonium salt was precipitated by adding ammonium chloride (2.4 g) and cooling to 0°C. The ammonium salt was filtered off and dissolved in water (140 ml), charcoaled twice at 80°C and the acid was precipitated at room temperature by addition of hydrochloric acid and was filtered off. The crude product was dissolved in ethyl acetate (100 ml) and the solution was washed 3 times with hydrochloric acid (2 N). By evaporating the solvent, 19 g of 3-amino-5- methoxycarbonyl-2,4,6-triiodobenzoic acid was isolated. Melting point 170°- 176°C.
A mixture of 3-amino-5-methoxycarbonyl-2,4,6-triiodobenzoic acid (198 g) and thionyl chloride (400 ml) was heated while stirring at 70°C for 16 h. The solid material dissolved slowly. Thionyl chloride was evaporated in vacuo, the residue dissolved in chloroform (1000 ml), the solution washed with water (80 ml each), twice with saturated sodium bicarbonate, then 5 times with 2 N sodium hydroxide solution and finally with water to neutral. The solution was dried with CaCl2 filtered and evaporated to dryness. The 3-amino-5- methoxycarbonyl-2,4,6-triiodobenzoyl chloride was dried at 50°C in vacuo. Yield: 203.0 g. Melting point 55°-60°C.
To the 3-amino-5-methoxycarbonyl-2,4,6-triiodobenzoyl chloride (53.0 g) was added acetic anhydride (106 ml). After stirring at room temperature for 20 min then insoluble material was filtered off (3-4 g). To the filtrate was added concentrated sulfuric acid (0.3 ml) whereby a yellowish product started to precipitate. The temperature reached about 50°C. The 3-acetamido-5- methoxycarbonyl-2,4,6-triiodobenzoyl chloride was isolated after storing in refrigerator overnight. Yield: 39.0 g. Melting point 210°-215°C.
The 3-acetamido-5-methoxycarbonyl-2,4,6-triiodobenzoyl chloride was dissolved in a mixture of dioxan and dimethylformamide. In the course of 2 h this solution was added dropwise to a solution of ethanolamine and triethylamine in dioxan. The stirring was continued. A sticky precipitate was filtered off. The filtrate was evaporated to dryness in vacuo. The residue was triturated with aqueous sodium bicarbonate, filtered off and mixed with first fraction. The combined solids were then suspended in aqueous sodium bicarbonate filtered off washed with water and dried in vacuo to give methyl 5-acetamido-2,4,6-triiodo-(N-β-hydroxyethyl)-isophthalamate.
The methyl 5-acetamido-2,4,6-triiodo-(N-β-hydroxyethyl)-isophthalamate was mixed with fresh distilled ethanolamine and stirred. The excess ethanolamine was removed in vacuo at 50°-60°C. The residue was dissolved in water, and charcoaled at pH 5.5. The crude product was precipitated with hydrochloric acid (pH 0.5) and filtered after stirring at 0°C. 5-Acetamido-2,4,6-triiodo-(N- β-hydroxyethyl)isophthalamic acid was suspended in ethanol and dissolved by addition of concentrated ammonia. The ammonium salt started to precipitate in the course and was isolated after stirring. The salt was dissolved in water, filtered and the acid was precipitated with hydrochloric acid (pH 0.5). After stirring the product was filtered off and dried in vacuo.

Therapeutic Function

Diagnostic aid

IOXITALAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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IOXITALAMIC ACID Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
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32321
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50
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
SALES@UHNSHANGHAI.COM
Country
China
ProdList
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Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
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AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
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Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15818
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
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View Lastest Price from IOXITALAMIC ACID manufacturers

Career Henan Chemical Co
Product
IOXITALAMIC ACID 28179-44-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-03

28179-44-4, IOXITALAMIC ACIDRelated Search:


  • Ioxitalamic
  • Acidum Joxitalamicum
  • 2,4,6-Triiodo-3-(acetylamino)-5-(2-hydroxyethylcarbamoyl)benzoic acid
  • 3-(Acetylamino)-2,4,6-triiodo-5-[[(2-hydroxyethyl)amino]carbonyl]benzoic acid
  • IOXITALAMIC ACID
  • sodium 3-acetamido-5-[(2-hydroxyethylamino)-oxomethyl]-2,4,6-triiodobenzoate
  • 3-(AcetylaMino)-5-[[(2-hydroxyethyl)aMino]carbonyl]-2,4,6-triiodobenzoic Acid
  • 3-AcetaMido-2,4,6-triiodo-(N-β-hydroxyethyl)isophthalic Acid MonoaMide
  • IoxitalaMate
  • Benzoic acid,3-(acetylaMino)-5-[[(2-hydroxyethyl)aMino]carbonyl]-2,4,6-triiodo-
  • iooxitalamic acid
  • 5-(Acetylamino)-3-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid
  • 5-Acetylamino-3-[N-(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid
  • AG-58107
  • 3-Acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic acid
  • IOXITALAMIC ACID USP/EP/BP
  • Telebrix
  • Vasobrix
  • 28179-44-4
  • C12H11I3N2O5
  • Amines
  • Aromatics
  • Diagnostic
  • Isotope Labelled Compounds
  • Intermediates & Fine Chemicals
  • Pharmaceuticals