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Iotalamic acid

Product Name
Iotalamic acid
CAS No.
2276-90-6
Chemical Name
Iotalamic acid
Synonyms
MI-216;Iothalamic;Metalamic acid;iothalamicacid;iotalamic acid;IOTHALAMIC ACID (200 MG);Iotalamic acid USP/EP/BP;5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid;3-Acetylamino-5-methylcarbamoyl-2,4,6-triiodobenzoic acid;3-Acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic acid
CBNumber
CB0501411
Molecular Formula
C11H9I3N2O4
Formula Weight
613.91
MOL File
2276-90-6.mol
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Iotalamic acid Property

Melting point:
>300 °C (decomp)
Boiling point:
520.2±50.0 °C(Predicted)
Density 
2.4079 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
Solid
pka
0.78±0.10(Predicted)
color 
Off-White to Pale Yellow
CAS DataBase Reference
2276-90-6(CAS DataBase Reference)
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Safety

HS Code 
2924296000
Toxicity
man,TDLo,unreported,2143uL/kg (2.143mL/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYELUNGS, THORAX, OR RESPIRATION: DYSPNEA,AJR, American Journal of Roentgenology. Vol. 162, Pg. 997, 1994.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1345002
Product name
Iotalamic acid
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200MG
Price
$106.8
Updated
2024/03/01
TRC
Product number
I736200
Product name
IothalamicAcid
Packaging
5mg
Price
$205
Updated
2021/12/16
Usbiological
Product number
164509
Product name
Iothalamic Acid
Packaging
5mg
Price
$496
Updated
2021/12/16
Crysdot
Product number
CD12094017
Product name
Iotalamicacid
Purity
98+%
Packaging
10mg
Price
$194
Updated
2021/12/16
Crysdot
Product number
CD12094017
Product name
Iotalamicacid
Purity
98+%
Packaging
5mg
Price
$104
Updated
2021/12/16
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Iotalamic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white Solid

Originator

Conray,Mallinckrodt Inc.,US,1962

Uses

Iothalamic Acid is used as a contrast medium in diagnostic radiology. Iothalamic Acid displayed the same level of nephrotoxicity against rat and human renal epithelial cells as conventional ionic contrast medioum.

Definition

ChEBI: Iotalamic acid is an organic molecular entity.

Manufacturing Process

Crude 5-amino-2,4,6-triiodo-N-methylisophthalamic acid (21.0 g) was dissolved in warm dimethylacetamide (40 ml) and acetic anhydride (30 ml) and concentrated sulfuric acid (2 drops) were added. This solution was heated on the steam bath for 2 hours, then heated at 110°C for 5 minutes, then cooled. Water and ammonium hydroxide were added to destroy the excess acetic anhydride, after which the mixture was evaporated to a volume of 50 ml. The cooled solution was acidified with concentrated hydrochloric acid and a tan solid was collected. The crude product was dissolved in 100 ml of water containing a slight excess of sodium hydroxide. The pH was adjusted to 4.5 with acetic acid, and the solution was treated with charcoal. The colorless solution was acidified with concentrated hydrochloric acid and cooled, and the precipitate was filtered off and dried under reduced pressure. The resulting 5- acetamido-2,4,6-triiodo-N-methylisophthalamic acid decomposes about 285°C and does not melt below 300°C.
5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid was slurried in water and dissolved by the addition of an equivalent quantity of N-methylglucamine. The solution was evaporated to dryness to yield the meglumate salt of 5- acetamido-2,4,6-triiodo-N-methylisophthalamic acid.

brand name

Conray(Mallinckrodt).

Therapeutic Function

Diagnostic aid (radiopaque medium)

Iotalamic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Iotalamic acid Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
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jkinfo@jkchemical.com
Country
China
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94657
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
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China
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32321
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50
China Langchem Inc.
Tel
0086-21-58956006
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0086-21-58956100
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China
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7811
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Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
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MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
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4861
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Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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Shanghai Hekang Biotechnology Co., Ltd.
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18939837085
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2880152141(QQ)
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youchemicals@gmail.com
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China
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Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
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021-33250306
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China
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4526
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Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
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View Lastest Price from Iotalamic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Iotalamic acid 2276-90-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
Iotalamic acid 2276-90-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-08-07

2276-90-6, Iotalamic acidRelated Search:


  • 3-(Acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]benzenecarboxylic acid
  • 3-(Acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]benzoic acid
  • 3-Acetylamino-5-methylcarbamoyl-2,4,6-triiodobenzoic acid
  • Metalamic acid
  • MI-216
  • 3-(acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]-benzoicaci
  • iothalamicacid
  • IOTHALAMIC ACID (200 MG)
  • 5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid
  • iotalamic acid
  • Iothalamic
  • Benzoic acid, 3-(acetylamino)-2,4,6-triiodo- 5-[(methylamino)carbonyl]-
  • 3-Acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic acid
  • Iotalamic acid USP/EP/BP
  • 2276-90-6
  • Organics