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iocarmic acid

Product Name
iocarmic acid
CAS No.
10397-75-8
Chemical Name
iocarmic acid
Synonyms
MP 2032;Iocarmic;iocarmic acid;iocarmic acid USP/EP/BP;3,3'-[Tetramethylenebis(carbonylimino)]bis(2,4,6-triiodo-5-methylcarbamoylbenzoic acid);5,5'-[Tetramethylenebis(carbonylimino)]bis[3-(methylcarbamoyl)-2,4,6-triiodobenzoic acid];3,3'-[(1,6-Dioxohexane-1,6-diyl)diimino]bis[2,4,6-triiodo-5-[(methylamino)carbonyl]benzoic acid];Benzoic acid, 3,3'-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo-5-[(methylamino)carbonyl]-
CBNumber
CB9878264
Molecular Formula
C24H20I6N4O8
Formula Weight
1253.86
MOL File
10397-75-8.mol
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iocarmic acid Property

Melting point:
302° (dec)
Boiling point:
868.1±65.0 °C(Predicted)
Density 
2.4238 (estimate)
pka
0.56±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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iocarmic acid Chemical Properties,Usage,Production

Originator

Myelotrast,Winthrop

Uses

Diagnostic aid (radiopaque medium, cholecystographic).

Definition

ChEBI: Iocarmic acid is an organic molecular entity.

Manufacturing Process

5-Amino-2,4,6-triiodo-N-methylisophthalamic acid (228.0 g, 4 mole) was added to stirred, heated dimethylacetamide (400 ml). When the temperature reached 95°C, adipoyl chloride (27.5 g, 0.15 mole) was added all at once, followed by an equal amount added slowly over a period of 15 min (a total of 55.0 g). After addition of the adipoyl chloride the solution was stirred at about 95°C for another 15 min, then poured into 2 L of hot water. As the above mixture cooled to room temperature a gum separated. The mother liquor was discarded and the gum was dissolved in water (2 L) with sufficient sodium hydroxide to complete solution. The solution was acidified with hydrochloric and acetic acids, treated with decolorizing charcoal and filtered. The filtrate was then strongly acidified with hydrochloric acid, which caused the separation of an apparently amorphous granular solid. This was filtered off, digested 0.5 h with hot ethanol (500 ml) collected, washed with ethanol and dried at 110°C. Yield of crude 5,5-(adipoyldiimino)-bis[2,4,6-triiodo-Nmethylisophthalamic acid].
The 5,5-(adipoyldiimino)-bis[2,4,6-triiodo-N-methylisophthalamic acid] was precipitated a second and third time from its sodium salt solution. The third precipitate was then dissolved in hot dimethylformamide (400 ml), and water (1.5 L) was slowly added. The mixture was digested and the hot mixture filtered, yielding a crystalline product which, after drying at 110°C, weighed 126.0 g (neutral equivalent, 724). This product was dissolved in dilute sodium hydroxide solution (1 L) and the solution was acidified (pH 5) and filtered into a hot stirred solution of hydrochloric acid (25 ml of concentrated acid in 75 ml water). The mixture was chilled and the solid collected, washed with water and dried at 110°C. Yield of 5,5-(adipoyldiimino)-bis[2,4,6-triiodo-Nmethylisophthalamic acid] 114.0 g (45%). Melting point, 302°C (corrected), with decomposition.

brand name

Dimeray (Mallinckrodt).

Therapeutic Function

Diagnostic aid

iocarmic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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iocarmic acid Suppliers

Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-87576359 15353716720
Email
1039@dideu.com
Country
China
ProdList
10009
Advantage
58

10397-75-8, iocarmic acid Related Search:


  • iocarmic acid
  • Iocarmic
  • 3,3'-[(1,6-Dioxohexane-1,6-diyl)diimino]bis[2,4,6-triiodo-5-[(methylamino)carbonyl]benzoic acid]
  • 3,3'-[Tetramethylenebis(carbonylimino)]bis(2,4,6-triiodo-5-methylcarbamoylbenzoic acid)
  • 5,5'-[Tetramethylenebis(carbonylimino)]bis[3-(methylcarbamoyl)-2,4,6-triiodobenzoic acid]
  • MP 2032
  • Benzoic acid, 3,3'-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo-5-[(methylamino)carbonyl]-
  • iocarmic acid USP/EP/BP
  • 10397-75-8
  • 10394-75-8
  • C24H20I6N4O8