Iotalamic acid
- Product Name
- Iotalamic acid
- CAS No.
- 2276-90-6
- Chemical Name
- Iotalamic acid
- Synonyms
- MI-216;Iothalamic;Metalamic acid;iothalamicacid;iotalamic acid;IOTHALAMIC ACID (200 MG);Iotalamic acid USP/EP/BP;5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid;3-Acetylamino-5-methylcarbamoyl-2,4,6-triiodobenzoic acid;3-Acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic acid
- CBNumber
- CB0501411
- Molecular Formula
- C11H9I3N2O4
- Formula Weight
- 613.91
- MOL File
- 2276-90-6.mol
Iotalamic acid Property
- Melting point:
- >300 °C (decomp)
- Boiling point:
- 520.2±50.0 °C(Predicted)
- Density
- 2.4079 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- form
- Solid
- pka
- 0.78±0.10(Predicted)
- color
- Off-White to Pale Yellow
- CAS DataBase Reference
- 2276-90-6(CAS DataBase Reference)
Safety
- HS Code
- 2924296000
- Toxicity
- man,TDLo,unreported,2143uL/kg (2.143mL/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYELUNGS, THORAX, OR RESPIRATION: DYSPNEA,AJR, American Journal of Roentgenology. Vol. 162, Pg. 997, 1994.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1345002
- Product name
- Iotalamic acid
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200MG
- Price
- $106.8
- Updated
- 2024/03/01
- Product number
- I736200
- Product name
- IothalamicAcid
- Packaging
- 5mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- 164509
- Product name
- Iothalamic Acid
- Packaging
- 5mg
- Price
- $496
- Updated
- 2021/12/16
- Product number
- CD12094017
- Product name
- Iotalamicacid
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $194
- Updated
- 2021/12/16
- Product number
- CD12094017
- Product name
- Iotalamicacid
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $104
- Updated
- 2021/12/16
Iotalamic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white Solid
Originator
Conray,Mallinckrodt Inc.,US,1962
Uses
Iothalamic Acid is used as a contrast medium in diagnostic radiology. Iothalamic Acid displayed the same level of nephrotoxicity against rat and human renal epithelial cells as conventional ionic contrast medioum.
Definition
ChEBI: Iotalamic acid is an organic molecular entity.
Manufacturing Process
Crude 5-amino-2,4,6-triiodo-N-methylisophthalamic acid (21.0 g) was
dissolved in warm dimethylacetamide (40 ml) and acetic anhydride (30 ml)
and concentrated sulfuric acid (2 drops) were added. This solution was heated
on the steam bath for 2 hours, then heated at 110°C for 5 minutes, then
cooled. Water and ammonium hydroxide were added to destroy the excess
acetic anhydride, after which the mixture was evaporated to a volume of 50
ml. The cooled solution was acidified with concentrated hydrochloric acid and
a tan solid was collected. The crude product was dissolved in 100 ml of water
containing a slight excess of sodium hydroxide. The pH was adjusted to 4.5
with acetic acid, and the solution was treated with charcoal. The colorless
solution was acidified with concentrated hydrochloric acid and cooled, and the
precipitate was filtered off and dried under reduced pressure. The resulting 5-
acetamido-2,4,6-triiodo-N-methylisophthalamic acid decomposes about 285°C
and does not melt below 300°C.
5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid was slurried in water
and dissolved by the addition of an equivalent quantity of N-methylglucamine.
The solution was evaporated to dryness to yield the meglumate salt of 5-
acetamido-2,4,6-triiodo-N-methylisophthalamic acid.
brand name
Conray(Mallinckrodt).
Therapeutic Function
Diagnostic aid (radiopaque medium)
Iotalamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Iotalamic acid Suppliers
- Tel
- --
- Fax
- --
- webmestre-substances@ineris.fr
- Country
- France
- ProdList
- 6024
- Advantage
- 58
- Tel
- --
- Fax
- --
- orders@edqm.eu
- Country
- France
- ProdList
- 1913
- Advantage
- 81
View Lastest Price from Iotalamic acid manufacturers
- Product
- Iotalamic acid 2276-90-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Iotalamic acid 2276-90-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-07