(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE

ChemicalBook > CAS DataBase List > (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE

(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE

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Product Name: (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE
CAS No.: 110529-22-1
Chemical Name: (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE
Synonyms: (2S)-(+)-N-Methyl-α;(S)-A,A-DIPHENYLMETHYLPROLINOL;(s)-α,α-Diphenylmethylprolinol;1,1-Diphenyl-N-methyl-L-prolinol;α,α-diphenyl-n-methyl-l-prolinol;à,à-diphenyl-n-methyl-l-prolinol;a,a-Diphenyl-N-methyl-L-prolinol;(S)-N-Methyl-alpha,alpha-diphenyl;Hydroxydiphenylmethylmethylpyrrolidine;(S)-ALPHA,ALPHA-DIPHENYLMETHYLPROLINOL
CBNumber: CB6408372
Molecular Formula: C18H21NO
Formula Weight: 267.37
MOL File: 110529-22-1.mol

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(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE Property

Melting point:: 66-72 °C
alpha: +52° (c=1, CHCl3)
Boiling point:: 406.8±25.0 °C(Predicted)
Density: 1.116±0.06 g/cm3(Predicted)
refractive index: 55 ° (C=1, CHCl3)
storage temp.: Sealed in dry,2-8°C
solubility: sol hexane, benzene, toluene, Et2O, cyclohexane, dichloromethane
pka: 13.15±0.29(Predicted)
form: Powder
color: white to pale-yellow
optical activity: [α]20/D +55±3°, c = 1% in chloroform stab. with amylenes
BRN: 4749387
CAS DataBase Reference: 110529-22-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-34
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H0768
Product name: (S)-(+)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine
Purity: >98.0%(GC)
Packaging: 1g
Price: $201
Updated: 2024/03/01

TCI Chemical

Product number: H0768
Product name: (S)-(+)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $805
Updated: 2024/03/01

Alfa Aesar

Product number: L19399
Product name: alpha,alpha-Diphenyl-N-methyl-L-prolinol, 97%
Purity: ee 99+%
Packaging: 250mg
Price: $83.3
Updated: 2021/12/16

Strem Chemicals

Product number: 07-1171
Product name: (2S)-(+)-N-Methyl-α,α-diphenyl-2-pyrrolidinemethanol, min. 98%
Packaging: 100mg
Price: $47
Updated: 2024/03/01

Strem Chemicals

Product number: 07-1171
Product name: (2S)-(+)-N-Methyl-α,α-diphenyl-2-pyrrolidinemethanol, min. 98%
Packaging: 250mg
Price: $99
Updated: 2024/03/01

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(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE Chemical Properties,Usage,Production

Reactions

Catalyst for the enantioselective addition of diethylzinc to α,β-unsaturated aldehydes

Chemical Properties

white to slightly yellow crystalline powder

Uses

(S)-(+)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine is used for chiral ligand for the enantioselective addition of dialkylzincs, alkynylzinc, and cyanomethylzinc bromide to aldehydes; chiral ligand for the enantioselective Reformatsky reaction; chiral ligand for the enantioselective Diels-Alder reaction; chiral auxiliary for asymmetric polymerization.

Preparation

Reaction of Phenylmagnesium Bromide with (S)-N-[(benzyloxy)carbonyl]proline methyl ester and subsequent reduction with Lithium Aluminum Hydride affords the (S)-(+)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine in 83% overall yield.

(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE manufacturers

Career Henan Chemical Co

Product: (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE 110529-22-1
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-09

110529-22-1, (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINERelated Search:

N-[(1S)-2'-aMino[1,1'-binaphthalen]-2-yl]-AcetaMide L-(+)-Prolinol N-Methyl-L-prolinol (R)-(-)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE (S)-(-)-2-AMINO-1,1-DIPHENYL-1-PROPANOL (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol (1S,2S)-(+)-Pseudoephedrine hydrochloride (S)-2-Dimethylamino-1-phenyletanol (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE (-)-N-METHYLEPHEDRINE (2S)-2-ISOPROPYLPYRROLIDINE (S)-2-DIPHENYLMETHYLPYRROLIDINE (S)-(-)N-CARBOMETHOXY-ALPHA,ALPHA-DIPHENYL -2-PYRROLIDINEMETHANOL,98% (S,S)-(+)-2,6-BIS[2-(HYDROXYDIPHENYLMETHYL)-1-PYRROLIDINYL-METHYL]-4-METHYLPHENOL (S)-(-)-1,1-DIPHENYL-2-AMINOPROPANE 1,1-DIPHENYL-TETRAHYDRO-PYRROLO[1,2-C]OXAZOL-3-ONE 2-BENZYLPYRROLIDINE (1S,2S)-(+)-N-METHYLPSEUDOEPHEDRINE

(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE

(S)-N-Methyl-alpha,alpha-diphenylpyrrolidinemethanol

Hydroxydiphenylmethylmethylpyrrolidine

a,a-Diphenyl-N-methyl-L-prolinol

(s)-n-methyl-à,à-diphenylpyrrolidinemethanol

(s)-α,α-diphenyl-n-methyl-2-pyrrolidinemethanol

à,à-diphenyl-n-methyl-l-prolinol

α,α-diphenyl-n-methyl-l-prolinol

1,1-Diphenyl-N-methyl-L-prolinol

ALPHA,ALPHA-DIPHENYL-N-METHYL-L-PROLINOL , EE 99%

ɑ,ɑ-Diphenyl-N-methyl-L-prolinol, 97%, ee 99+%

(S)-N-Methyl-alpha,alpha-diphenyl

alpha,alpha-Diphenyl-N-methyl-L-prolinol, 97%, ee 99+%

^a,^a-Diphenyl-N-methyl-L-prolinol, 97%, ee 99+%

(S)-alpha,alpha-Diphenylmethylprolinol,98%

[( S)-α,α-Diphenyl-N-methyl-2-pyrrolidnemethanol]

S-N-methyl-α,α-Diphenyl-2-pyrrolidinemethanol

(2S)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine

[(2S)-1-Methylpyrrolidin-2-yl](diphenyl)methanol, alpha,alpha-Diphenyl-N-methyl-L-prolinol

α,α-Diphenyl-N-Methyl-L-prolinol >=96.0% (suM of enantioMers, GC)

(S)-(+)-DIPHENYL(1-METHYLPYRROLIDIN-2-YL)METHANOL

(S)-ALPHA,ALPHA-DIPHENYLMETHYLPROLINOL

(S)-ALPHA,ALPHA-DIPHENYL-N-METHYL-2-PYRROLIDINEMETHANOL

(S)-N-METHYL- ALPHA,ALPHA -DIPHENYL-2-PYRROLIDINE METHANOL

(S)-A,A-N-METHYL DIPHENYL-2-PYRROLIDINE METHANOL

(S)-A,A-DIPHENYLMETHYLPROLINOL

(S)-A,A-DIPHENYL-N-METHYL-2-PYRROLIDINEMETHANOL

(2S)-(+)-N-Methyl-α,α-diphenyl-2-pyrrolidinemethanol, min. 98%

(2S)-(+)-N-Methyl-α

(2S)-N-Methyl-α,α-diphenyl-2-pyrrolidinemethanol

(2S)-N-Methyl-α,α-diphenyl-2-pyrrolidinemethanol,99%e.e.

ALPHA,ALPHA-DIPHENYL-N-METHYL-L-PROLINOL

(2S)-1-METHYL-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL

(S)-N-Methyl-a,a-diphenyl-2-pyrrolidinemethanol

α,α-Diphenyl-N-methyl-L-prolinol, 97%, for synthesis

(S)-(+)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine&gt

2-Pyrrolidinemethanol, 1-methyl-α,α-diphenyl-, (2S)-

(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE USP/EP/BP

(s)-α,α-Diphenylmethylprolinol

(S)-(1-Methylpyrrolidin-2-yl)diphenylmethanol

110529-22-1

Proline-Based Organocatalysts

Chiral Catalysts, Ligands, and Reagents

Asymmetric Synthesis

Synthetic Organic Chemistry