(1S,2S)-(+)-Pseudoephedrine hydrochloride
- Product Name
- (1S,2S)-(+)-Pseudoephedrine hydrochloride
- CAS No.
- 345-78-8
- Chemical Name
- (1S,2S)-(+)-Pseudoephedrine hydrochloride
- Synonyms
- PSEUDOEPHEDRINE HYDROCHLORIDE;PSEUDOEPHEDRINE HCL;sudafed;novafed;a)]-;GRCA;GPR162;sinufed;Otrinol;symptom2
- CBNumber
- CB1399716
- Molecular Formula
- C10H16ClNO
- Formula Weight
- 201.69
- MOL File
- 345-78-8.mol
(1S,2S)-(+)-Pseudoephedrine hydrochloride Property
- Melting point:
- 185-188 °C(lit.)
- alpha
- 61 º (c=5, H2O,2dm tube)
- storage temp.
- Refrigerator (+4°C)
- solubility
- Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride.
- pka
- 9.22(at 25℃)
- form
- buffered aqueous solution
- biological source
- rabbit
- Merck
- 13,8007
- BRN
- 3915112
- LogP
- -1.74 at 23℃ and pH7
- CAS DataBase Reference
- 345-78-8(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (345-78-8)
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 22-36/37/38-36/38-39/23/24/25-23/24/25-11
- Safety Statements
- 26-36-24/25-45-36/37-16-7
- RIDADR
- 1544
- WGK Germany
- 3
- RTECS
- UL5950000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29394200
- Toxicity
- LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H336May cause drowsiness or dizziness
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- SAB2105153
- Product name
- Anti-TFF1 antibody produced in rabbit
- Purity
- affinity isolated antibody
- Packaging
- 100μL
- Price
- $524
- Updated
- 2024/03/01
- Product number
- HPA003425
- Product name
- Anti-TFF1 antibody produced in rabbit
- Purity
- Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
- Packaging
- 25μL
- Price
- $294
- Updated
- 2024/03/01
- Product number
- HPA003425
- Product name
- Anti-TFF1 antibody produced in rabbit
- Purity
- Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
- Packaging
- 100μL
- Price
- $547
- Updated
- 2024/03/01
- Product number
- E2750
- Product name
- (+)-Pseudoephedrine hydrochloride
- Purity
- ≥98%
- Packaging
- 25g
- Price
- $127
- Updated
- 2024/03/01
- Product number
- BP413
- Product name
- Pseudoephedrine hydrochloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $247
- Updated
- 2024/03/01
(1S,2S)-(+)-Pseudoephedrine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor.
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine.
brand name
Efidac (ALZA); Novafed (Sanofi Aventis); Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert).
Biological Activity
Trefoil factor 1 is a protein encoded by the TFF1 gene in humans. The proteins are small secretory proteins characterized by three intra-chain disulfide bonds forming the trefoil motif or P-domain. It is abundantly expressed on mucosal surfaces and especially within the gastrointestinal tract. The protein belongs to highly conserved proteins th at play an essential role in epithelial regeneration within the gastrointestinal tract. Its expression is strongly induced after mucosal injury and may function as a gastric tumor suppressor gene. It is expressed in various types of carcinomas including breast cancer. The gene contains an estrogen response element and its expression can be regulated by estrogen. Increased expression of this gene is found to be associated with tumor progression in some tumors and missense mutations in the gene have been detected in gastric cancer.
Contact allergens
This sympathomimetic a-adrenergic agonist is found in plants of the genus Ephedra (Ephedraceae) and is systemically used as a nasal decongestant. It can induce drug skin reactions such as acute generalized exanthematic pustulosis or generalized eczema.
Clinical Use
Nasal decongestant
Drug interactions
Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive
effect of adrenergic neurone blockers.
Anaesthetics: increased risk of ventricular
arrhythmias with isoflurane.
Antibacterials: risk of hypertensive crisis with
linezolid.
Antidepressants: risk of hypertensive crisis with
MAOIs and moclobemide.
Dopaminergics: avoid concomitant use with
selegiline and rasagiline.
Metabolism
A small amount of pseudoephedrine is hepatically
metabolised by N-demethylation.
It is excreted largely unchanged in the urine with small
amounts of its hepatic metabolite.
Purification Methods
1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.]