FMOC-L-CYCLOPROPYLGLYCINE

Product Name: FMOC-L-CYCLOPROPYLGLYCINE
CAS No.: 1212257-18-5
Chemical Name: FMOC-L-CYCLOPROPYLGLYCINE
Synonyms: Fmoc-L-Gly(cPr)-OH;Fmoc-L-Cyclopropylgly;Fmoc-CyclopropylGly-OH;FMOC-L-CYCLOPROPYLGLYCINE;(S)-Fmoc-cyclopropylglycine;N-Fmoc-S-2-Cyclopropylglycine;Fmoc-(S)-2-cyclopropylglycine;FMOC-L-CYCLOPROPYLGLYCINE ,98% min;Fmoc-(S)-Amino-cyclopropyl-acetic acid;Fmoc-L-cyclopropylglycine≥ 99% (HPLC, Chiral purity)
CBNumber: CB6409672
Molecular Formula: C20H19NO4
Formula Weight: 337.37
MOL File: Mol file

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FMOC-L-CYCLOPROPYLGLYCINE Property

Boiling point:: 577.1±33.0 °C(Predicted)
Density: 1.332±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.85±0.10(Predicted)
form: powder
color: White
optical activity: 17.134°(C=0.01g/ml DCM)
InChI: InChI=1S/C20H19NO4/c22-19(23)18(12-9-10-12)21-20(24)25-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17-18H,9-11H2,(H,21,24)(H,22,23)/t18-/m0/s1
InChIKey: YMLZBPTXRMNAFP-SFHVURJKSA-N
SMILES: C1(COC(=O)N[C@H](C(O)=O)C2CC2)C2C=CC=CC=2C2C=CC=CC=21

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Safety

Hazard Codes: Xi
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: F657745
Product name: Fmoc-L-cyclopropylglycine
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 277693
Product name: Fmoc-L-cyclopropylglycine
Packaging: 50mg
Price: $333
Updated: 2021/12/16

TRC

Product number: F657745
Product name: Fmoc-L-cyclopropylglycine
Packaging: 5g
Price: $460
Updated: 2021/12/16

Apolloscientific

Product number: OR2679
Product name: (S)-Amino(cyclopropyl)acetic acid, N-FMOC protected
Packaging: 250mg
Price: $145
Updated: 2021/12/16

Activate Scientific

Product number: AS85613
Product name: Fmoc-(S)-2-cyclopropylglycine
Purity: 95+% ee
Packaging: 1g
Price: $166
Updated: 2021/12/16

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FMOC-L-CYCLOPROPYLGLYCINE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Fmoc-L-cyclopropylglycine is used in preparation of tailored Cyclodepsipeptides as potent non-covalent serine protease inhibitors.

Synthesis

28920-43-6

49606-99-7

1212257-18-5

GENERAL STEPS: 2.3 g of Na2CO3 was dissolved in 34 mL of water and chloroformic acid-9-fluorenylmethyl ester and (S)-2-amino-2-cyclopropylacetic acid were added with stirring. The reaction mixture was stirred at room temperature. After completion of the reaction, the product was characterized by FT-IR and NMR.FT-IR (pure): 2669, 2335, 2159, 2106, 1785, 1689, 1550, 1489, 1463, 1433, 1369, 1296, 1253, 1172, 1128, 1001 cm^-1.^1H NMR ( CDCl3, 600 MHz): δ = 7.76 (d, 2H, J = 7.2 Hz), 7.60-7.59 (m, 2H), 7.41-7.39 (m, 2H), 7.32-7.30 (m, 2H), 5.36 (d, 1H, J = 6 Hz), 4.45-4.39 (m, 2H), 4.24-4.21 (m, 1H ), 3.83-3.81 (m, 1H), 1.14-1.13 (m, 1H), 0.65-0.46 (m, 5H) ppm. ^13C NMR (CDCl3, 150 MHz): δ = 176.6, 156.2, 143.9, 143.8, 141.4, 127.9, 127.2, 125.2, 125.1 , 120.1, 67.3, 57.4, 47.3, 13.9, 3.4 ppm. HRMS (ESI): m/z [M + Na]^+ Calculated value C20H19NO4Na 360.1206, measured value 360.1193.

References

[1] Journal of the American Chemical Society, 2016, vol. 138, # 5, p. 1698 - 1708
[2] Patent: WO2016/138288, 2016, A1. Location in patent: Page/Page column 124

FMOC-L-CYCLOPROPYLGLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-L-CYCLOPROPYLGLYCINE Suppliers

China 84 India 1 United Kingdom 1 United States 10 Global 96

HBCChem, Inc.

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HBCChem Inc.

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PepTech Corporation

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1212257-18-5, FMOC-L-CYCLOPROPYLGLYCINERelated Search:

FMOC-ALA(BETA-CYCLOBUTYL)-OH FMOC-L-CYCLOPROPYLALANINE FMOC-L-CYCLOPENTYLGLYCINE Fmoc-cyclopropylglycine FMOC-D-CYCLOPROPYLGLYCINE L-Cyclopropylglycine

FMOC-L-CYCLOPROPYLGLYCINE

L-2-Cyclopropylglycine, N-FMOC protected, (S)-Cyclopropyl({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclopropylacetic acid

(2S)-2-cyclopropyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid

(S)-Fmoc-cyclopropylglycine

(alphaS)-alpha-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclopropaneacetic acid

Fmoc-(S)-Amino-cyclopropyl-acetic acid

Fmoc-L-cyclopropylglycine≥ 99% (HPLC, Chiral purity)

(9H-Fluoren-9-yl)MethOxy]Carbonyl Cyclopropylglycine (EE >98%)

N-Fmoc-S-2-Cyclopropylglycine

Cyclopropaneacetic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (αS)-

Fmoc-(S)-2-cyclopropylglycine

N-α-(9-Fluorenylmethoxycarbonyl)-L-α-cyclopropylglycine

Fmoc-L-Cyclopropylgly

(2S)-2-cyclopropyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)aceticaci

Fmoc-L-Gly(cPr)-OH

FMOC-L-CYCLOPROPYLGLYCINE ,98% min

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclopropylacetic acid - [F91498]

Fmoc-CyclopropylGly-OH

1212257-18-5

Unusual amino acids

a-amino