ChemicalBook > CAS DataBase List > 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE

Product Name: 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
CAS No.: 182004-65-5
Chemical Name: 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
Synonyms: IN1281;KB-R7943;KB-R7943 MESYLATE;KB-R7943, NCX inhibitor;KB-R7943 mesylate, 10 mM in DMSO;KB-R7943 - CAS 182004-65-5 - Calbiochem;-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE;2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE;S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate;4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate
CBNumber: CB6422033
Molecular Formula: C17H21N3O6S2
Formula Weight: 427.49
MOL File: 182004-65-5.mol

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2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Property

Melting point:: >214°C (dec.)
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in DMSO (up to 50 mg/ml).
form: White crystalline solid
color: Tan
Water Solubility: water: 4mg/mL
DMSO: 40mg/mL
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChIKey: WGIKEBHIKKWJLG-UHFFFAOYSA-N
SMILES: S(O)(=O)(=O)C.C(C1C=CC(N(=O)=O)=CC=1)OC1C=CC(CCSC(N)=N)=CC=1

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Safety

HS Code: 2930.90.2900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 420336-M
Product name: KB-R7943
Packaging: 1 unit
Price: $154
Updated: 2025/07/31

TCI Chemical

Product number: N0966
Product name: S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $119
Updated: 2025/07/31

TCI Chemical

Product number: N0966
Product name: S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $413
Updated: 2025/07/31

Cayman Chemical

Product number: 16352
Product name: KB-R7943 (mesylate)
Purity: ≥98%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 16352
Product name: KB-R7943 (mesylate)
Purity: ≥98%
Packaging: 10mg
Price: $77
Updated: 2024/03/01

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2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Chemical Properties,Usage,Production

Description

KB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50‘s = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) Ki = 5.5 μM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM) and block NMDA receptors (IC50 = 13.4 μM).4

Uses

KB-R7943 Mesylate is a selective inhibitor of the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.

General Description

A cell-permeable inhibitor of the influx/reverse mode of the Na⁺/Ca²⁺ exchanger (NCX) (IC₅₀ = 4.3 μM for NCX1, 4.7 μM for NCX2, and 1.4 μM for NCX3). Directly modulates Na⁺/Mg²⁺ exchange in a Ca²⁺-dependent manner. Reported ot offer neuronal and cardio-protection against ischemic injury. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC₅₀<10 μM).

Biological Activity

Potent, selective inhibitor of the reverse mode of the Na + /Ca 2+ exchanger (IC 50 = 0.7 mM). Does not affect Na + -dependent transport systems, Na + channels or ionotropic glutamate receptors.

Biochem/physiol Actions

Target IC50: 4.3 μM, 4.7 μM, and 1.4 μM for NCX1,NCX2, and NCX3, respectively

storage

Room temperature

References

[1] T IWAMOTO M S T Watano. A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.[J]. The Journal of Biological Chemistry, 1996, 271 37: 22391-22397. DOI:10.1074/jbc.271.37.22391
[2] K. HOYT. Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.[J]. Molecular Pharmacology, 1998, 53 4 1: 742-749. DOI:10.1124/mol.53.4.742
[3] J SANTO-DOMINGO. The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter[J]. British Journal of Pharmacology, 2009, 151 5: 647-654. DOI:10.1038/sj.bjp.0707260
[4] TATIANA BRUSTOVETSKY. KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I[J]. British Journal of Pharmacology, 2010, 162 1: 255-270. DOI:10.1111/j.1476-5381.2010.01054.x

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE manufacturers

Career Henan Chemical Co

Product: 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE 182004-65-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-01-29

182004-65-5, 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATERelated Search:

BAPTA-AM Vanoxerine dihydrochloride SKF 96365 HYDROCHLORIDE IONOMYCIN SULFURYL FLUORIDE Salvia polyphenolate IMINOCTADINE TRIS(ALBESILATE) 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE

Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester methanesulfonate

Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester monomethanesulfonate

KB-R7943

KB-R7943 MESYLATE

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE

2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA, METHANE SULFONATE

<i>S</i>-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate

4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate

S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate

KB-R7943 - CAS 182004-65-5 - Calbiochem

IN1281

KB R7943; KB-R 7943; KBR7943; 182004-65-5; KB-R7943 MESYLATE; 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE; IN1281; KB-R 7943

S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate &gt

Carbamimidothioic Acid 4-[(4-Nitrobenzyl)oxy]phenethyl Ester Methanesulfonate

-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE

KB-R7943, NCX inhibitor

KB-R7943 mesylate, 10 mM in DMSO

182004-65-5

C16H17N3O3SCH3SO3H

C17H21N3O6S2

C16H17N3O3SCH4O3S

CH4O3SC16H17N3O3S

Signalling

Ion transporter and other ion channel