L-Citrulline

Product Name: L-Citrulline
CAS No.: 372-75-8
Chemical Name: L-Citrulline
Synonyms: CITRULLINE;(S)-2-AMINO-5-UREIDOPENTANOIC ACID;H-CIT-OH;L-CITRULINE;L-CIT;L-Cit-OH;L-Citrullne;L-Citrullin;N5-(aminocarbonyl)-L-Ornithine;L-CTRULLINE
CBNumber: CB6423883
Molecular Formula: C6H13N3O3
Formula Weight: 175.19
MOL File: 372-75-8.mol

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L-Citrulline Property

Melting point:: 214 °C
alpha: 25.5 º (c=8, 6N HCl)
Boiling point:: 306.48°C (rough estimate)
Density: 1.2919 (rough estimate)
refractive index: 26 ° (C=8, 6mol/L HCl)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Aqueous Acid (Sparingly). Water (Slightly)
form: Crystals or Crystalline Powder
pka: 2.43(at 25℃)
color: White
Odor: Odorless
optical activity: +4.025 (H2O) +24.225 (1 mol dm-3 HCl)
Water Solubility: 200 g/L (20 ºC)
Merck: 14,2331
BRN: 6055157
InChIKey: RHGKLRLOHDJJDR-BYPYZUCNSA-N
LogP: -3.190
CAS DataBase Reference: 372-75-8(CAS DataBase Reference)
EPA Substance Registry System: L-Ornithine, N5-(aminocarbonyl)- (372-75-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
TSCA: Yes
HS Code: 29241900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3191
Product name: L-Citrulline
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $200
Updated: 2024/03/01

Sigma-Aldrich

Product number: C7629
Product name: L-Citrulline
Purity: ≥98% (TLC)
Packaging: 1kg
Price: $3000
Updated: 2024/03/01

Sigma-Aldrich

Product number: 19936
Product name: L-Citrulline
Purity: certified reference material, TraceCERT?
Packaging: 10MG
Price: $84.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1133842
Product name: L-Citrulline
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $467
Updated: 2024/03/01

TCI Chemical

Product number: C0372
Product name: L-Citrulline
Purity: >98.0%(T)
Packaging: 25g
Price: $27
Updated: 2024/03/01

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L-Citrulline Chemical Properties,Usage,Production

Chemical Properties

White powder

Originator

StaminO2,ErgoPharm

Uses

L-Citrulline, is used as an essential intermediate in the biosynthesis of nitric oxide from L-arginine . It is also used as a nutritional drink and biochemical reagent.

Uses

An amino acid, L-Citrulline can be used in the treatment of asthenia and as an essential intermediate in the biosynthesis of nitric oxide.

Definition

ChEBI: L-citrulline is the L-enantiomer of citrulline. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a protective agent, a nutraceutical, a micronutrient, a human metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is an enantiomer of a D-citrulline. It is a tautomer of a L-citrulline zwitterion.

Manufacturing Process

Citrulline is obtained as a result of a reaction of L-arginine hydrochloride with sodium hydroxide, copper oxide and hydrogen sulfide.
In practice it is usually used as malate salt

Therapeutic Function

Stimulant, Detoxicant

benefits

L-citrulline is used for Alzheimer's disease, dementia, fatigue, muscle weakness, sickle cell disease, erectile dysfunction, high blood pressure, and diabetes. It is used for heart disease, body building, increasing energy, and for improving athletic performance.

Biochem/physiol Actions

L-Citrulline, when orally administered is found to ameliorate the condition of sickle cell disease in humans. L-citrulline can be a replacement for L-arginine administration in case of defective NO synthetase. L-Citrulline supplementation is found to fulfill the purpose of NO-dependent signaling.

target

NO | IL Receptor

Drug interactions

There are no reported side effects of L-citrulline.
However, the supplement may affect the way certain drugs work in your body. Do not take this supplement if you are taking:
Nitrates for heart disease
ED drugs such as sildenafil (Revatio, Viagra), tadalafil (Cialis), or vardenafil (Levitra, Staxyn)
Combining L-citrulline with those drugs may cause a dangerous drop in blood pressure.
You should also be careful when taking L-citrulline if you take any type of blood pressure medicine.
Do not use L-citrulline if you are pregnant or breastfeeding.

Purification Methods

Likely impurities are arginine and ornithine. Crystallise S-citrulline from water by adding 5 volumes of EtOH. Also crystallise it from water by addition of MeOH. [Ellenbogen J Am Chem Soc 74 5198 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2491-2494 1961, Beilstein 4 IV 2647.]

L-Citrulline Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Citrulline Suppliers

Americas 1 Australia 1 Belgium 2 Brazil 1 Canada 8 China 660 Czech Republic 1 Europe 4 France 1 Germany 13 India 36 Italy 2 Japan 9 Mexico 1 Poland 2 Singapore 1 South Korea 2 Spain 1 Switzerland 8 United Kingdom 17 United States 96 Global 867

INTATRADE GmbH

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Beckmann-Kenko GmbH

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Evonik Industries AG.

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F. & A. PHARMA-Handels-GmbH

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chemcube

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SERVA Electrophoresis GmbH

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IRIS Biotech GmbH

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PARAGOS

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Service Chemical Inc.

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ABCR GmbH & CO. KG

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Degussa AG

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Merck Schuchardt OHG

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AppliChem GmbH

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View Lastest Price from L-Citrulline manufacturers

Hebei Andu Technology Com.,Ltd

Product: L-Citrulline 372-75-8
Price: US $15.00/kg
Min. Order: 1kg
Purity: ≥98%
Supply Ability: 3000tons/month
Release date: 2024-07-20

HebeiShuoshengImportandExportco.,Ltd

Product: L-Citrulline 372-75-8
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-08

Dorne Chemical Technology co. LTD

Product: L-Citrulline 372-75-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-03-26

372-75-8, L-CitrullineRelated Search:

Pivalic acid ALTRENOGEST 5-AMINOVALERIC ACID L-Tryptophan L(+)-Arginine Glycine Semicarbazide Estradiol valerate MAGNESIUM DIPROPYLACETATE HYDRATE 2-Propylpentanoic acid L-Serine L-Glutamine L-Prolinamide L-Proline L-Methionine N-[(tert-Butoxy)carbonyl]-D-tryptophan BOC-CIT-OH DL-CITRULLINE

Ibuprofen Impurity 78

Arginine Impurity 2（Arginine EP Impurity B）（Citrulline）

L-CTRULLINE

L-Citrullne

Arginine EP Impurity B

n5-(aminocarbonyl)-l-ornithin

N5-(aminocarbonyl)-L-Ornithine

ALPHA-AMINO-DELTA-UREIDO-N-VALERIC ACID

N-ORN(CARBAMOYL)-OH

N-DELTA-CARBAMOYL-L-ORNITHINE

(S)-2-AMINO-5-UREIDOPENTANOIC ACID

L-CITRULLINERESEARCH GRADE

L-Citrulline,(S)-2-Amino-5-ureidopentanoic acid, L-2-Amino-5-ureidovaleric acid

L-Citrulline, extra pure

L-2-AMINO-5-UREIDO-N-VALERIC ACID

2-Amino-5-(carbamoylamino)pentanoic acid

a-Amino-D-ureidovaleric acid

D-Carbamylornithine

D-Ureidonorvaline

(S)-2-Amino-5-ureidovaleric acid

Citrullin

NSC 27425

Nδ-CarbaMylornithine

α-AMino-δ-ureidovaleric Acid

δ-Ureidonorvaline

L-Citrulline-d7

L-CITRULLINE (5,5-D2, 98%)

L-CITRULLINE (5-13C, 99%

4,4,5,5-D4, 95%) MICROBIOLOGICAL/PYROGEN TESTED

3,3,4-D3, 98%)

L(+)-2-AMINO-5-UREIDOVALERIC ACID

L-2-AMINO-5-UREIDOVALERIC ACID

L-2-AMINE-5-UREIDOVAIERIC ACID

L-2-AMINE-5-UREIDOVALERIC ACID

L-CITRULINE

L-CIT

L-(+)-CITRULLINE

L-CITRULLINE

CITRULLINE, L-

CITRULLINE

H-CIT-OH

H-L-CIT-OH

H-ORN(CONH2)-OH

H-ORN(CARBAMOYL)-OH

L-Cit-OH

L-Citrullin

L-Citrulline (1.12117)

L-Citrulline[(+)-2-amino-5-ureidopentanoic acid]

L-CITRULLINE FOR BIOCHEMISTRY

L-Citrulline,98%

N5-CARBAMOYL-L-ORNITHINE

L(+)-Citrulline, 99+%

L-Citrulline(-ureido-13C)

L-Ornithine, N5-(aminocarbonyl)-

(2S)-2-amino-5-(carbamoylamino)pentanoic acid

CITRULLINE, L-(RG)

Citrulline Malate, L-

(S)-2-Amino-5-ureidopentanoic acid L-2-Amino-5-ureidovaleric acid