L-Citrulline
- Product Name
- L-Citrulline
- CAS No.
- 372-75-8
- Chemical Name
- L-Citrulline
- Synonyms
- CITRULLINE;(S)-2-AMINO-5-UREIDOPENTANOIC ACID;H-CIT-OH;L-CITRULINE;L-CIT;L-Cit-OH;L-Citrullne;L-Citrullin;N5-(aminocarbonyl)-L-Ornithine;L-CTRULLINE
- CBNumber
- CB6423883
- Molecular Formula
- C6H13N3O3
- Formula Weight
- 175.19
- MOL File
- 372-75-8.mol
L-Citrulline Property
- Melting point:
- 214 °C
- alpha
- 25.5 º (c=8, 6N HCl)
- Boiling point:
- 306.48°C (rough estimate)
- Density
- 1.2919 (rough estimate)
- refractive index
- 26 ° (C=8, 6mol/L HCl)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Aqueous Acid (Sparingly). Water (Slightly)
- form
- Crystals or Crystalline Powder
- pka
- 2.43(at 25℃)
- color
- White
- Odor
- Odorless
- optical activity
- +4.025 (H2O) +24.225 (1 mol dm-3 HCl)
- Water Solubility
- 200 g/L (20 ºC)
- Merck
- 14,2331
- BRN
- 6055157
- InChIKey
- RHGKLRLOHDJJDR-BYPYZUCNSA-N
- LogP
- -3.190
- CAS DataBase Reference
- 372-75-8(CAS DataBase Reference)
- EPA Substance Registry System
- L-Ornithine, N5-(aminocarbonyl)- (372-75-8)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36-26
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29241900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR3191
- Product name
- L-Citrulline
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 500MG
- Price
- $200
- Updated
- 2024/03/01
- Product number
- C7629
- Product name
- L-Citrulline
- Purity
- ≥98% (TLC)
- Packaging
- 1kg
- Price
- $3000
- Updated
- 2024/03/01
- Product number
- 19936
- Product name
- L-Citrulline
- Purity
- certified reference material, TraceCERT?
- Packaging
- 10MG
- Price
- $84.3
- Updated
- 2024/03/01
- Product number
- 1133842
- Product name
- L-Citrulline
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $467
- Updated
- 2024/03/01
- Product number
- C0372
- Product name
- L-Citrulline
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $27
- Updated
- 2024/03/01
L-Citrulline Chemical Properties,Usage,Production
Chemical Properties
White powder
Originator
StaminO2,ErgoPharm
Uses
L-Citrulline, is used as an essential intermediate in the biosynthesis of nitric oxide from L-arginine . It is also used as a nutritional drink and biochemical reagent.
Uses
An amino acid, L-Citrulline can be used in the treatment of asthenia and as an essential intermediate in the biosynthesis of nitric oxide.
Definition
ChEBI: L-citrulline is the L-enantiomer of citrulline. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a protective agent, a nutraceutical, a micronutrient, a human metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is an enantiomer of a D-citrulline. It is a tautomer of a L-citrulline zwitterion.
Manufacturing Process
Citrulline is obtained as a result of a reaction of L-arginine hydrochloride with
sodium hydroxide, copper oxide and hydrogen sulfide.
In practice it is usually used as malate salt
Therapeutic Function
Stimulant, Detoxicant
benefits
L-citrulline is used for Alzheimer's disease, dementia, fatigue, muscle weakness, sickle cell disease, erectile dysfunction, high blood pressure, and diabetes. It is used for heart disease, body building, increasing energy, and for improving athletic performance.
Biochem/physiol Actions
L-Citrulline, when orally administered is found to ameliorate the condition of sickle cell disease in humans. L-citrulline can be a replacement for L-arginine administration in case of defective NO synthetase. L-Citrulline supplementation is found to fulfill the purpose of NO-dependent signaling.
target
NO | IL Receptor
Drug interactions
There are no reported side effects of L-citrulline.
However, the supplement may affect the way certain drugs work in your body. Do not take this supplement if you are taking:
Nitrates for heart disease
ED drugs such as sildenafil (Revatio, Viagra), tadalafil (Cialis), or vardenafil (Levitra, Staxyn)
Combining L-citrulline with those drugs may cause a dangerous drop in blood pressure.
You should also be careful when taking L-citrulline if you take any type of blood pressure medicine.
Do not use L-citrulline if you are pregnant or breastfeeding.
Purification Methods
Likely impurities are arginine and ornithine. Crystallise S-citrulline from water by adding 5 volumes of EtOH. Also crystallise it from water by addition of MeOH. [Ellenbogen J Am Chem Soc 74 5198 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2491-2494 1961, Beilstein 4 IV 2647.]
L-Citrulline Preparation Products And Raw materials
Raw materials
Preparation Products
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- +91-22-26355701
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View Lastest Price from L-Citrulline manufacturers
- Product
- L-Citrulline 372-75-8
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- ≥98%
- Supply Ability
- 3000tons/month
- Release date
- 2024-07-20
- Product
- L-Citrulline 372-75-8
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-08
- Product
- L-Citrulline 372-75-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-03-26