Characterization Applications Features/benefits Guidelines for use Physical Properties Safety
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Drometrizole

Characterization Applications Features/benefits Guidelines for use Physical Properties Safety
Product Name
Drometrizole
CAS No.
2440-22-4
Chemical Name
Drometrizole
Synonyms
UV-P;TINUVIN P;2-(2-HYDROXY-5-METHYLPHENYL)BENZOTRIAZOLE;2-(2H-BENZOTRIAZOL-2-YL)-P-CRESOL;UV-71;Benazol II;RIASORB UV-P;Absorber UV-P;UV ABSORBER UV-P;2-(2H-Benzotriazol-2-yl)-p-kresol
CBNumber
CB6426334
Molecular Formula
C13H11N3O
Formula Weight
225.25
MOL File
2440-22-4.mol
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Drometrizole Property

Melting point:
125.5-129.5 °C(lit.)
Boiling point:
bp10 225°
Density 
1.38
vapor pressure 
0Pa at 20℃
refractive index 
1.5600 (estimate)
Flash point:
54°C
storage temp. 
15-25°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
8.15±0.43(Predicted)
color 
Off-White to Pale Yellow
Water Solubility 
173μg/L at 20℃
Merck 
14,3447
Stability:
Hygroscopic
InChIKey
MCPKSFINULVDNX-UHFFFAOYSA-N
LogP
4.2 at 25℃
CAS DataBase Reference
2440-22-4(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-(2440-22-4)
EPA Substance Registry System
2-(2H-Benzotriazol-2-yl)-p-cresol (2440-22-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-53-43
Safety Statements 
22-24/25-36/37
WGK Germany 
1
RTECS 
GO6860000
HS Code 
29339900
Toxicity
LD50 oral in mouse: 6500mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CRM96697
Product name
2-(2-Hydroxy-5-methylphenyl)benzotriazole
Purity
certified reference material, TraceCERT?
Packaging
100MG
Price
$151
Updated
2024/03/01
Sigma-Aldrich
Product number
533203
Product name
2-(2-Hydroxy-5-methylphenyl)benzotriazole
Purity
97%
Packaging
25g
Price
$87.9
Updated
2024/03/01
Sigma-Aldrich
Product number
1228009
Product name
Drometrizole
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
H0560
Product name
2-(2-Hydroxy-5-methylphenyl)benzotriazole
Purity
>99.0%(HPLC)(T)
Packaging
25g
Price
$62
Updated
2024/03/01
TCI Chemical
Product number
H0560
Product name
2-(2-Hydroxy-5-methylphenyl)benzotriazole
Purity
>99.0%(HPLC)(T)
Packaging
500g
Price
$225
Updated
2024/03/01
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Drometrizole Chemical Properties,Usage,Production

Characterization

Drometrizole is an ultraviolet light absorber (UVA) of the hydroxyphenyl benzotriazole class, imparting good light stability to a wide variety of polymers.

Applications

Drometrizole provides ultraviolet protection in a wide variety of polymers including styrene homoand copolymers, engineering plastics such as polyesters and acrylic resins, polyvinyl chloride, and other halogen containing polymers and copolymers (e.g. vinylidenes), acetals and cellulose esters. Elastomers, adhesives, polycarbonate blends, polyurethanes, and some cellulose esters and epoxy materials also benefit from the use of Drometrizole.
   

Features/benefits

Drometrizole features a strong absorption of ultraviolet radiation in the 300-400 nm region. It also has a high degree of photostability over long periods of light exposure. The high absorbance combined with photostability and the ability to release absorbed energy in non sensitizing ways make Drometrizole an effective stabilizer against the effects of ultraviolet light.

Guidelines for use

The use levels of Drometrizole range between 0.10% and 0.50%, depending on substrate and performance requirements of the final application. Drometrizole can be used alone or in a variety of blends and combinations with Ciba IRGAFOS®, Ciba IRGANOX® and Ciba CHIMASSORB® stabilizers where often a synergistic performance is observed. Drometrizole may react with various heavy metal ions to form salts or complexes. For example, if Drometrizole comes into contact with iron or cobalt ions, colored complexes are formed. Reducing and oxidizing agents used in polymerization and curing processes have no effect on the stability of Drometrizole.

Physical Properties

Safety

In accordance with good industrial practice, handle with care and avoid unnecessary personal contact. Protect skin. Prevent contamination of the environment. Avoid dust formation and ignition sources.

Chemical Properties

Light yellow powder

Uses

An ultraviolet light absorber for stabilizing plastics and other organic materials against discoloration and deterioration.

Uses

2(2-Hydroxy-5-methylphenyl)benzotriazol is an UV adsorber for use in plastics, cosmetics, dental materials, acrylic materials, dyes, etc.

Uses

Drometrizole is an intermediate reactant in the synthesis of UV light absorbers for polyester fibers.

Definition

Drometrizole is a member of triazoles.

Application

Intermediate reactant in the synthesis of UV light absorbers for polyester fibers
Reactant for synthesis of:
Benzotriazole UV absorbers with a blocked hydroxy group for us in UV curable paint
Maleimide-bound benzotriazole monomer to use for emulsion polymerization
Used in:
Microstereophotolithography and shape memory alloy for fabrication of miniaturized actuators
PVS and wood / PVC composites as a stabilizer
Acrylonitrile-butadiene-styrene as a UV absorber.

Flammability and Explosibility

Not classified

Toxicity evaluation

The mutagenicity study of drometrizole was performed using Salmonella typhimurium strains TA1538 and TA98 with metabolic activation in the Ames’ test. Spot test (10 and 100 mg drometrizole/plate) and top agar method (50 and 100 mg drometrizole/plate) were conducted. The results showed that drometrizole was not mutagenic.Mice and rats were administered 5.0 or 10.0 g/kg of drometrizole in sunflower oil by stomach tube intubation. After body weight and behaviour were monitored for 3 weeks, acute toxicity of drometrizole was evaluated to be low. The oral lethal dose (LD50) of drometrizole in mice was reported to be 6.5 g/kg and > 5.0g/kg. Oral toxicity was evaluated in rats for nail care cosmetics containing 1%, 0.3% and 0.03% of drometrizole. The LD50 of products containing 1% of drometrizole was > 15.0 g/kg. The LD50 of products containing 0.3% and 0.03% drometrizole was > 5.0 g/kg. No acute toxicity was observed in these treatments.

Drometrizole Preparation Products And Raw materials

Raw materials

Preparation Products

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Drometrizole Suppliers

ACETO France SAS
Tel
--
Fax
--
Email
gsaint-clair@fr.aceto.com
Country
France
ProdList
211
Advantage
58
Interchim S.A.
Tel
--
Fax
--
Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
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View Lastest Price from Drometrizole manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Drometrizole 2440-22-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-07
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
uv absorber P 2440-22-4
Price
US $40.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-23
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Drometrizole 2440-22-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000kg/month
Release date
2021-07-27

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