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SJA6017

Product Name
SJA6017
CAS No.
190274-53-4
Chemical Name
SJA6017
Synonyms
SJA6017;Calpain-In-4;Calpain Inhibitor 4;CALPAIN INHIBITOR VI;4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL;4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE;N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL;SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal;Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde;Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-
CBNumber
CB6427018
Molecular Formula
C17H25FN2O4S
Formula Weight
372.45
MOL File
190274-53-4.mol
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SJA6017 Property

Density 
1.185±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 5 mg/ml
form 
A lyophilized solid
pka
9.04±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23942
Product name
Calpain Inhibitor VI
Purity
≥95%
Packaging
1mg
Price
$73
Updated
2024/03/01
Biosynth Carbosynth
Product number
FC111099
Product name
Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
Packaging
500ug
Price
$135
Updated
2021/12/16
AK Scientific
Product number
0719DA
Product name
CalpainInhibitorVI
Packaging
1mg
Price
$179
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC111099
Product name
Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
Packaging
1mg
Price
$236
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000054
Product name
SJA6017
Purity
95.00%
Packaging
1MG
Price
$722.8
Updated
2021/12/16
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SJA6017 Chemical Properties,Usage,Production

Description

Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases μ-calpain (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM). It also inhibits cathepsins B and L (IC50s = 15 and 1.6 nM, respectively). It is selective for these calpains and cathepsins over other cysteine and serine proteases, factor VIIa, factor Xa, trypsin, chymotrypsin, and proteasome. In an in vitro porcine model of cataract, calpain inhibitor VI decreases the degree of cataract by 40% when used at a concentration of 0.8 μM. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Calpain inhibitor VI improves functional outcome and reduces apoptotic cell death in a rat model of spinal cord injury.

SJA6017 Preparation Products And Raw materials

Raw materials

Preparation Products

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SJA6017 Suppliers

China 30 United Kingdom 2 United States 8 Global 40
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82

190274-53-4, SJA6017Related Search:

SJA6017

  • SJA6017
  • N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL
  • 4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE
  • 4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL
  • CALPAIN INHIBITOR VI
  • SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal
  • Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
  • Calpain Inhibitor 4
  • Calpain-In-4
  • Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-
  • 190274-53-4