ChemicalBook > CAS DataBase List > U-46619

U-46619

Product Name
U-46619
CAS No.
56985-40-1
Chemical Name
U-46619
Synonyms
U-46619;U 46619,U46619;9,11-Methanoxy-PGH2;11-Methanoepoxy PGH2;9,11-Methanoepoxy PGH2;U46619, U-46619, U 46619;11α,9α-Epoxymethanoprostaglandin H2;U-46619 - CAS 56985-40-1 - Calbiochem;9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO;4-alpha,5-beta(z),6-alpha(1e,3s*)))-r-(1-alph
CBNumber
CB6437516
Molecular Formula
C21H34O4
Formula Weight
350.49
MOL File
56985-40-1.mol
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U-46619 Property

Boiling point:
519.7±30.0 °C(Predicted)
Density 
1.092±0.06 g/cm3(Predicted)
Flash point:
-10 °C
storage temp. 
-20°C
solubility 
≥100 mg/mL in DMSO, ≥100 mg/mL in Ethanol, ≥100 mg/mL in DMF, ≥2 mg/mL in PBS pH 7.2
pka
4.76±0.10(Predicted)
form 
solution
color 
Colorless to light yellow
BRN 
4267334
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Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36-66-67
Safety Statements 
16-26
RIDADR 
UN 1231 3/PG 2
WGK Germany 
2
RTECS 
MJ9681090
8-10-23
Toxicity
LD50 intravenous in mouse: 66ug/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D8174
Product name
9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α
Purity
solution, 10 mg/mL in methyl acetate
Packaging
1mg
Price
$339
Updated
2024/03/01
Sigma-Aldrich
Product number
538944
Product name
U-46619
Packaging
1mg
Price
$242
Updated
2022/05/15
Cayman Chemical
Product number
16450
Product name
U-46619
Purity
≥98%
Packaging
1mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
16450
Product name
U-46619
Purity
≥98%
Packaging
5mg
Price
$437
Updated
2024/03/01
Sigma-Aldrich
Product number
D8174
Product name
9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α
Purity
solution, 10 mg/mL in methyl acetate
Packaging
5mg
Price
$1330
Updated
2024/03/01
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U-46619 Chemical Properties,Usage,Production

Uses

U 46619 is a PGH2 analog that may be used as a thromboxane A2 (TP) receptor agonist affecting mitogenic growth of vascular smooth muscle in humans.

Biological Activity

PGH 2 (TXA 2 ) analog that is a potent and stable thromboxane A 2 (TP) receptor agonist (EC 50 = 0.035 μ M). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK-293 cells expressing TP α and TP β receptors.

Biochem/physiol Actions

Thromboxane receptor agonist.

in vitro

u46619 showed a biphasic effect on human platelets. shape change and mlcp occurred at low concentrations of this compound (ec50 = 0.035 um and 0.057 um), whereas serotonin release, platelet at higher concentrations (ec50 = 0.536 um and 1.31 um). the effect on platelet shape change and mlcp is receptor mediated [3].

in vivo

u46619, through activation of eta and etb receptors, elicits renal cortical vasoconstriction and medullary vasodilation in the rat [2]. in conscious shr (spontaneously hypertensive rats), 1-100 nmol/kg u-46619 (i.c.v.) induced a dose-related increase in blood pressure but had no significant effect on heart rate [1].

storage

Store at -20°C

References

[1] sirén al, svartstrm-fraser m, paakkari i. central cardiovascular effects of the endoperoxide analogue u-46619 in rats. prostaglandins leukot med. 1985 mar; 17 (3): 381-6.
[2] hantz h, adesuyi a, adebayo o. differential effects of u46619 on renal regional hemodynamics in the rat: involvement of endothelin. j pharmacol exp ther. 2001 oct; 299 (1): 372-6.
[3] morinelli ta1, niewiarowski s, daniel jl, smith jb. receptor-mediated effects of a pgh2 analogue (u 46619) on human platelets. am j physiol. 1987 nov; 253 (5 pt 2): h1035-43.

U-46619 Preparation Products And Raw materials

Raw materials

Preparation Products

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U-46619 Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
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China
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
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Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
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ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
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Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
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China
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51456
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EMMX Biotechnology LLC
Tel
888-539-0666
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888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
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60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
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Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Tel
0571-85361029
Fax
0571-85361029
Email
synstar518@163.com
Country
China
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1990
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58

56985-40-1, U-46619Related Search:


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  • U-46619 - CAS 56985-40-1 - Calbiochem
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